布地奈德联合孟鲁司特治疗小儿咳嗽变异性哮喘的效果

刘旭东?许慧芳?李林楷

[摘要] 目的 探讨布地奈德联合孟鲁司特治疗小儿咳嗽变异性哮喘的效果。方法 选取我院2014年4月～ 2015年9月收治的108例小儿咳嗽变异性哮喘患者，采用随机分配的方式，分为观察组和对照组各54例，对照组患者给予雾化吸入布地奈德治疗，观察组患者给予布地奈德联合孟鲁司特治疗，对比两组患者的临床效果。结果 两组患者治疗后血清IgE、白细胞介素-4、肿瘤坏死因子-α下降明显（P<0.05），观察组患者下降水平明显低于对照组（P<0.05），均具有统计学意义；观察组患者症状的缓解与消失时间也远远低于对照组（P<0.05），具有统计学意义；治疗后1年随访，观察组患者复发率为3.70%，对照组患者复发率为11.11%，两组有显著差异（P<0.05），具有统计学意义。结论 布地奈德联合孟鲁司特治疗小儿咳嗽变异性哮喘有着较好的临床效果，不良反应较少，安全性较高，值得在临床推广应用。

[关键词] 布地奈德；孟鲁司特；小儿咳嗽变异性哮喘

[中图分类号] R725.6 [文献标识码] A [文章编号] 2095-0616（2017）14-35-03

Effect of budesonide combined with montelukast in the treatment of children with cough variant asthma

LIU Xudong XU Huifang LI Linkai

Zhuhai Maternal And Child Health Care Hospital， Zhuhai 519000， China

[Abstract] Objective To investigate the effect of budesonide combined with montelukast in the treatment of children with cough variant asthma. Methods 108 cases of children with cough variant asthma in our hospital from April 2014 to September 2016 were selected and divided into observation group and control group with 54 cases in each group， by random allocation method. Patients in control group were treated with budesonide inhalation therapy， and patients in observation group were given budesonide combined with montelukast treatment. The clinical effects were compared between the two groups. Results After treatment， The serum IgE， interleukin -4， tumor necrosis factor-α of the two groups were decreased significantly（P<0.05）. The decrease range of the observation group was lower than that of the control group（P<0.05）. And there was statistical significance. The remission and disappearance time of the patients in the observation group was much lower than that in the control group（P<0.05）. And there was statistical significance. After 1 years of treatment， the recurrence rate was 3.70% in the observation group， and it was11.11% in the control group， and there was a significant difference between the two groups（P<0.05）， which was statistically significant. Conclusion Budesonide combined with montelukast in the treatment of children with cough variant asthma has good clinical effect. It has less adverse reaction， and high safety. It is worthy of clinical application

[Key words] Budesonide； Montelukast； Cough variant asthma

咳嗽變异性哮喘是常见的支气管哮喘病之一，是引发儿童慢性咳嗽的主要危险因素，在儿童中的发病率较高，对儿童的日常生活以及心肺功能造成了严重的影响。咳嗽变异性哮喘的主要症状为气道的高反应性，一般没有明显的哮喘症状，大多表现为反复咳嗽[1]。在咳嗽变异性哮喘的发生与发展过程中，白三烯有着促进炎性反应细胞聚集、增加血管通透性的效果，能参与到呼吸道炎性反应过程中，因此被广泛运用于治疗[2]。本次研究采用布地奈德联合孟鲁司特的方式治疗小儿咳嗽变异性哮喘，取得了较好的效果。具体报道如下。