血液透析对老年慢性肾功能衰竭患者炎症标志物的影响研究

青琴+艾衣坦·阿依特哈孜

[摘要] 目的 探討血液透析对老年慢性肾功能衰竭患者炎症标志物的影响。 方法 方便选取2014年10月—2016年1月于博州人民医院肾内科进行血液透析的老年慢性肾功能衰竭患者82例为观察组，同时选取100名于该院体检的健康老年人为对照组，所选取的两组对象年龄均为60～75岁。分别于入院时、14 d、30 d、60 d后检测透析前后血清脂联素、CRP、IL-6等炎症标志物的水平，将两组炎症标志物水平进行对比。 结果 观察组患者血清脂联素、CRP、IL-6分别为（14.88±2.56）mg/L、（7.35±1.88）mg/L、（60.33±6.77）pg/L，对照组患者血清脂联素、CRP、IL-6分别为（7.10±0.89）mg/L、（2.11±0.25）mg/L、（43.25±5.20）pg/L，观察组患者血清脂联素、CRP、IL-6显著高于对照组，差异有统计学意义（P<0.05）；观察组患者炎症标志物血清脂联素、CRP、IL-6的水平随着时间的延长不断升高，但各时间点透析前后水平差异无统计学意义（P>0.05）；4个时刻点血液透析前炎症标志物水平相比，2个月后比其他3个时刻点显著升高，差异有统计学意义（P<0.05）。结论 血液透析不能降低老年慢性肾功能衰竭患者炎症标志物血清脂联素、CRP、IL-6的水平，因此有必要在临床治疗中进行抗炎治疗。

[关键词] 血液透析；老年；慢性肾功能衰竭；炎症标志物

[中图分类号] R692.5 [文献标识码] A [文章编号] 1674-0742（2017）01（a）-0035-03

[Abstract] Objective To investigate the effect of hemodialysis on inflammatory markers in elderly patients with chronic renal failure. Methods Convenient selection from October 2014 to January 2016 in the Department of Nephrology dialysis Bozhou people's Hospital of elderly patients with chronic renal failure and 82 cases of the observation group， and selected 100 healthy elderly patients in our hospital as the control group， the two groups of age were selected are 60～75 years old. The levels of serum adiponectin， CRP， IL-6 and other inflammatory markers were compared between the 30 groups at admission， 14 days， days and 60 days respectively， and the levels of inflammatory markers were compared between the two groups. Results The levels of serum adiponectin， CRP and IL-6 in the observation group were （14.88 ± 2.56） mg/L， （7.35 ± 1.88） mg/L， （60.33 ± 6.77） pg/L， the levels of serum adiponectin， CRP and IL-6 in the control group were（7.10 ± 0.89） mg/L， （2.11 ± 0.25） mg/L， （43.25 ± 5.20） pg/L， in the observation group， serum adiponectin， CRP and IL-6 were significantly higher than that of the control group ，the difference was statistically significant（P<0.05）； the observation group of patients with inflammatory markers， serum adiponectin， CRP， IL-6 levels increased with the prolonging of time， but there was no significant difference between before and after each time point of dialysis levels， there was no statistically significant（P>0.05）； the 4 time points of hemodialysis preinflammatory marker levels compared to 2 months later than the other three time points were significantly increased ，the difference was statistically significant（P<0.05）. Conclusion Hemodialysis can not reduce the level of serum adiponectin， CRP and IL-6 in elderly patients with chronic renal failure， so it is necessary to carry out anti-inflammatory treatment in clinical treatment.