微创肺表面活性物质及无创持续性气道压力在低体重早产儿呼吸窘迫综合征治疗中的应用

温可崇　　陈广明　　梁振才　　叶柳清

[關键词] 微创肺表面活性物质;无创持续性气道压力;低体重;早产儿;呼吸窘迫综合征

[中图分类号] R722          [文献标识码] B          [文章编号] 1673-9701（2021）21-0054-04

The application of minimally invasive pulmonary surfactant and non-invasive continuous positive airway pressure in the treatment of respiratory distress syndrome in premature infants with low birth weight

WEN Kechong   CHEN  Guangming   LIANG Zhencai   YE  Liuqing

Department of Neonatology， Boai Hospital of Zhongshan City in Guangdong Province， Zhongshan   528400， China

[Abstract] Objective To explore the application effect of minimally invasive pulmonary surfactant [less invasive surfactant administration （LISA）] and non-invasive continuous positive airway pressure （ncpap） in the treatment of neonatal respiratory distress syndrome （NRDS） in premature infants with low birth weight. Methods A total of 50 low birth weight premature infants with NRDS admitted to the Department of Neonatology in Boai Hospital of Zhongshan were retrospectively selected as the study subjects. They were divided into the study group （ncpap+LISA， n=22） and the control group （ncpap， n=28） according to the treatment schemes.The efficacy，duration of noninvasive ventilation， length of hospital stay， complication rate， blood gas analysis before treatment and after 1 d of treatment were compared between the two groups. Results The total effective rate of treatment in the study group （95.45%） was higher than that in the control group （67.86%）. However， the duration of noninvasive ventilation and length of hospital stay in the study group [（3.52±1.12） d vs. （4.36±1.39） d， respectively] were lower than those in the control group [（17.21±2.65） d vs. （19.87±3.43） d， respectively] （P<0.05）. There was no statistically significant difference in the complication rate between the study group and the control group（P>0.05）.The arterial partial pressure of oxygen （PaO2） and potential of hydrogen （pH） in both groups increased at 1 d of treatment compared with those before treatment. However， the oxygenation index （OI） and partial pressure of carbon dioxide in artery（PaCO2） decreased during the same period（P<0.05）. The PaO2 and pH values in the study group were higher than those in the control group at 1 d of treatment， while OI and PaCO2 were lower than those in the control group during the same period（P<0.05）. Conclusion In the treatment of NRDS in premature infants with low birth weight， the combined application of LISA and ncpap can improve the efficacy and hypoxia， shorten the duration of noninvasive ventilation and promote the rehabilitation of children， and is safe and reliable.