腹腔镜联合戈舍瑞林治疗卵巢型子宫内膜异位症的效果
2019-01-08廖红艾小燕朱奕融
廖红 艾小燕 朱奕融
[摘要]目的 探討腹腔镜联合戈舍瑞林治疗卵巢型子宫内膜异位症的效果。方法 选取2015年1月~2016年1月我院收治的60例卵巢型子宫内膜异位症患者作为研究对象,按照就诊顺序的不同分为观察组(30例)与对照组(30例)。对照组采用腹腔镜手术治疗,术后给予孕三雌酮胶囊,观察组在对照组基础上联合戈舍瑞林缓释植入剂治疗。比较两组的临床疗效、相关症状评分、治疗时间、随访情况。结果 观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组的痛经、月经不调、性交痛、周期性直肠刺激征、不孕评分均低于对照组,差异有统计学意义(P<0.05)。观察组的月经、排卵恢复时间均短于对照组,差异有统计学意义(P<0.05)。观察组的妊娠成功率高于对照组,差异有统计学意义(P<0.05)。观察组的疾病复发率低于对照组,差异有统计学意义(P<0.05)。结论 采用腹腔镜联合戈舍瑞林治疗卵巢型子宫内膜异位症,可明显缩短患者病症改善时间,降低疾病复发率,提高患者妊娠成功率。
[关键词]卵巢型子宫内膜异位症;戈舍瑞林缓释植入剂;腹腔镜;疾病复发率;妊娠情况
[中图分类号] R71 [文献标识码] A [文章编号] 1674-4721(2019)11(b)-0129-03
Effect of laparoscopy combined with Goserelin in the treatment of ovarian endometriosis
LIAO Hong AI Xiao-yan ZHU Yi-rong
Department of Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang 330006, China
[Abstract] Objective To investigate the effect of laparoscopy combined with Goserelin in the treatment of ovarian endometriosis. Methods Sixty patients with ovarian endometriosis admitted to our hospital from January 2015 to January 2016 were selected as the study subjects, and they were divided into observation group (30 cases) and control group (30 cases) according to the order of treatment. The control group was treated with laparoscopic surgery, and the Pregnant gynecological Capsules were given after operation. The observation group was treated with Goserelin Sustained-release Implants on the basis of the control group. The clinical efficacy, related symptom scores, treatment time, and follow-up were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). The dysmenorrhea, irregular menstruation, sexual pain, periodic rectal irritation and infertility scores in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The recovery time of menstruation and ovulation in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). The pregnancy success rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The recurrence rate of the disease in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Laparoscopy combined with Goserelin in the treatment of ovarian endometriosis can significantly shorten the improvement time, reduce the recurrence rate and improve the success rate of pregnancy.
综上所述,采用戈舍瑞林与腹腔镜治疗卵巢型子宫内膜异位症患者,效果良好,值得临床推广。
[参考文献]
[1]黄莺莺.戈舍瑞林联合腹腔镜治疗卵巢型子宫内膜异位症患者的临床效果[J].医疗装备,2017,30(21):125-126.
[2]吴能秀,谢熙,刘超斌,等.腹腔镜手术治疗盆腔内子宫内膜异位症合并不孕症术后自然妊娠相关分析[J].福建医科大学学报,2017,51(5):326-329.
[3]中华医学会妇产科学分会子宫内膜异位症协作组.子宫内膜异位症的诊治指南[J].中华妇产科杂志,2015,12(3):161-169.
[4]张元珍.妇产科学实践指南[M].武汉:武汉大学出版社,2004.
[5]陈媛媛,茅红艳.腹腔镜术后醋酸戈舍瑞林治疗子宫内膜异位症的观察[J].中国继续医学教育,2017,9(30):107-109.
[6]凡连云,万贵平.亮丙瑞林与戈舍瑞林对卵巢子宫内膜异位症术后复发及妊娠成功率的影响[J].中国当代医药,2017, 24(30):98-101.
[7]耿丹.腹腔镜术后结合注射用醋酸戈舍瑞林治疗子宫内膜异位症的效果探析[J].中国现代药物应用,2016,10(15):150-151.
[8]赵俊波.重度卵巢型子宫内膜异位症患者术前AMH水平对术后自然妊娠评估的应用意义[J].现代妇产科进展,2019, 22(1):26-30.
[9]马霞.腹腔镜手术联合醋酸戈舍瑞林治疗子宫内膜异位症的效果[J].河南外科学杂志,2016,22(5):52-53.
[10]黄晓花,韩毓,韦佩佳,等.不同腹腔镜剥离术式对子宫内膜异位症患者性激素、窦卵泡数及卵巢体积的影响[J].中国内镜杂志,2017,23(5):74-78.
[11]陳帆,杨华娣.腹腔镜手术联合促性腺激素释放激素激动剂对子宫内膜异位症不孕的临床疗效研究[J].中国内镜杂志,2016,22(9):71-74.
[12]李焱,张震宇,刘崇东.子宫内膜异位症合并不孕患者腹腔镜术后药物治疗妊娠结局分析[J].实用妇产科杂志,2015,31(1):53-56.
[13]何丽清,蔡序子,王艳,等.子宫内膜异位症腹腔镜保守治疗术后联用GnRHa对临床妊娠率的影响[J].南方医科大学学报,2018,38(5):98-102.
[14]王敬华,祁建青,任琼珍.促性腺激素释放激素激动剂联合腹腔镜手术治疗子宫内膜异位症的疗效分析[J].中国妇幼保健,2015,30(35):6395-6397.
[15]区家茵.腹腔镜手术联合肌内注射GnRH-a治疗子宫内膜异位症效果及其对Th1/Th2漂移的影响[J].山东医药,2018,11(2):83-86.
(收稿日期:2019-05-10 本文编辑:焦曌元)