盐酸帕罗西汀结合小剂量非典型抗精神病药物在老年抑郁症患者中的应用价值

刘玉红

[关键词] 抗精神病药;帕罗西汀;老年抑郁症;不良反应;生存质量;奥氮平

[中图分类号] R749.41          [文献标识码] B          [文章编号] 1673-9701（2021）21-0030-04

Application value of paroxetine acid combined with low-dose atypical antipsychotics in elderly patients with depression

LIU Yuhong

Department of Psychiatry， Inner Mongolia Mental Health Center， Inner Mongolia Hohhot，   010010， China

[Abstract] Objective To investigate the effect of paroxetine hydrochloride combined with low-dose atypical antipsychotics in the treatment of elderly patients with depression. Methods Ninety-two elderly patients with depression treated in our hospital from January 2019 to December 2019 were selected. They were divided into the control group and the experimental group using the random number table method， with 46 patients in each group. The control group were treated with paroxetine， and the experimental group were treated with paroxetine combined with low-dose atypical antipsychotics （olanzapine）. The differences in the total effective rate， quality of life scale （HOQOL-BREF） score， anxiety self-rating scale （SAS） score， Hamilton depression scale （HAMD-17） score and adverse event scale score were compared between the two groups after 8 weeks of treatment. Results The total effective rate of patients in the experimental group （100.00%） was higher than that in the control group （73.91%）， with statistically significant difference （P<0.05）. There were no statistically significant differences in the HOQOL-BREF score， SAS score， and HAMD-17 score between the two groups before treatment （P>0.05）. There were no statistically significant differences in the HOQOL-BREF score， SAS score and HAMD-17 score between the two groups after treatment （P<0.05）. There was no statistically significant difference in the adverse event scale score between the two groups （P>0.05）. Conclusion Paroxetine combined with olanzapine can be considered as the treatment for elderly patients with depression. It can effectively improve the quality of life of patients and is worthy of application.

[Key words] Antipsychotics; Paroxetine; Elderly depression; Adverse event; Quality of life; Olanzapine

抑郁癥属于临床上常见的一种心理障碍疾病，其病因复杂多样，主要表现为情绪低落、失眠多梦甚至绝望自杀，具有较高的发病率[1]。随着近年来社会不断发展，在日常工作和生活中人们面临的压力越来越大，使得抑郁症在我国的发病率不断上升[2]。此外，我国正在逐步进入老龄化社会，导致老年人口有所增加，老年抑郁症发生率也呈上升趋势，通常老年患者的抑郁症状不典型，病程较长，很容易发展为慢性病[3]。目前，药物干预是临床治疗抑郁症的主要手段之一，可以有效缓解患者的不良心理情绪，改善抑郁行为，提高生活质量[4]。帕罗西汀是目前精神科比较常用的新型抗抑郁剂，临床上应用较多[5]。近些年来，非典型抗精神病药物已逐渐作为首选药物广泛应用于各类精神疾病的治疗，尤其是用于初发病患者，其中又以奥氮平最受欢迎，奥氮平主要用于治疗精神分裂症[6]。因此，选取研究病例为我院老年抑郁症患者，将上述药物应用其中，现报道如下。