糖尿病肾病合并IgA肾病的临床病理特征及治疗预后
2020-11-30林福龙
林福龙
[摘要] 目的 分析糖尿病肾病合并IgA肾病的临床病理特征及治疗预后。方法 选择2017年1月—2019年1月该院收治56例糖尿病肾病合并IgA肾病患者为实验组。将同期收治的55例糖尿病肾病未合并IgA肾病患者为对照组。比较两组临床病理特征及治疗预后。结果 血糖水平比较,空腹血糖、餐后2 h血糖水平比较,差异无统计学意义(P>0.05)。实验组的尿蛋白定量(≥3.5 g/24 h)、视网膜病变、高血压等发生率均低于对照组,差异有统计学意义(P<0.05)。生存率比较,实验组低于对照组[(96.43%(54/56) vs 98.18%(54/55)],差异无统计学意义(χ2=0.324,P=0.569)。结论 糖尿病肾病合并IgA肾病与糖尿病肾病未合并IgA患者,比较二者临床病理特点,表示其相似性与差异性并存,治疗后预后效果良好。
[关键词] 糖尿病肾病;免疫球蛋白A肾病;临床病理特征;治疗预后;分析
[中图分类号] R4 [文献标识码] A [文章编号] 1672-4062(2020)10(a)-0182-03
[Abstract] Objective To analyze the clinicopathological characteristics and treatment prognosis of diabetic nephropathy combined with IgA nephropathy. Methods From January 2017 to January 2019, 56 patients with diabetic nephropathy and IgA nephropathy were admitted to the hospital as the experimental group. The 55 patients with diabetic nephropathy without IgA nephropathy who were admitted during the same period were selected as the control group. The clinicopathological characteristics and treatment prognosis of the two groups were compared. Results There was no statistically significant difference in blood glucose levels, fasting blood glucose and blood glucose levels 2 h after a meal (P>0.05). The rate of urine protein quantitative (≥3.5 g/24 h), retinopathy, and hypertension in the experimental group were lower than those in the control group, and the difference was statistically significant (P<0.05). Compared with the survival rate, the experimental group was lower than the control group[(96.43%(54/56) vs 98.18%(54/55)], which was not statistically significant difference (χ2=0.324, P=0.569). Conclusion Patients with diabetic nephropathy with IgA nephropathy and diabetic nephropathy without IgA, comparing the clinicopathological characteristics of the two indicate that their similarities and differences coexist, and the prognosis after treatment is good.
[Key words] Diabetic nephropathy; Immunoglobulin A nephropathy; Clinicopathological characteristics; Treatment prognosis; Analysis
糖尿病是一种代谢性疾病,受遗传、免疫功能紊乱和微生物感染等因素影响,临床表现为高血糖、多饮、多食、多尿以及体重消瘦等症状,若长期处于高血糖和代谢紊乱症状,易损害重要器官[1]。IgA肾病(Ig Anephropathy),属慢性肾小球肾炎,是一种进展性疾病,发病率较高,是免疫介导的原发性肾小球疾病,临床表现以血尿为主,存在蛋白尿和腎功能损伤现象,是终末期肾病的常见原因[2]。目前,临床对糖尿病肾病合并IgA的报道比较少。为提高糖尿病合并肾脏损伤的认识,该院以2017年1月—2019年1月收治的56例糖尿病肾病合并IgA肾病患者和55例糖尿病肾病未合并IgA糖尿病肾病患者为研究对象,分析其临床特征及治疗预后,现报道如下。
1 资料与方法
1.1 一般资料
该院收治56例糖尿病肾病合并IgA肾病患者为实验组。将同期收治的55例糖尿病肾病未合并IgA肾病患者为对照组。其中实验组,男性患者29例,女性患者27例;最小年龄30岁,最大年龄78岁,平均年龄(41.29±2.28)岁;最短病程1年,最长病程3年,平均病程(1.39±0.34)年。对照组,男性患者29例,女性患者26例;最小年龄30岁,最大年龄77岁,平均年龄(41.48±2.19)岁;最短病程1年,最长病程3年,平均病程(1.42±0.39)年。