自拟柴苓饮联合干扰素及利巴韦林治疗慢性丙型肝炎的临床研究

吴艺锋

[摘要] 目的 探討自拟中药方柴苓饮联合干扰素及利巴韦林治疗慢性丙型肝炎的临床疗效。 方法 选取2014年1月～2018年5月期间在我院接受慢性丙型肝炎治疗的患者26例，将所选患者随机分为研究组与对照组，对照组患者接受聚乙二醇干扰素α-2a与利巴韦林治疗，研究组同时加用自拟中药方柴苓饮治疗，并对两组患者进行为期6个月的随访。对两组患者改善肝脏硬度的有效率、血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、碱性磷酸酶（ALP）以及γ-谷氨酰转移酶（GGT）的指标以及白蛋白（ALB）、球蛋白（GLB）、白蛋白/球蛋白（A/G）的改善情况进行比较。 结果 研究组改善肝脏硬度的有效率高于对照组，差异有统计学意义（P<0.05）;研究组患者血清中ALT、AST、ALP以及GGT水平低于对照组，差异有统计学意义（P<0.05）;研究组治疗后的ALB、GLB、A/G的改善高于对照组，差异有统计学意义（P<0.05）。 结论 在对慢性丙型肝炎患者使用聚乙二醇干扰素α-2a与利巴韦林治疗过程中，加用自拟中药方柴苓饮，能更有效地改善患者的肝脏硬度，减轻肝脏炎症，改善肝脏功能，值得在临床上进行推广。

[关键词] 中药药方;联合治疗;干扰素;利巴韦林;慢性丙型肝炎

[中图分类号] R512.63          [文献标识码] A          [文章编号] 1673-9701（2019）15-0017-03

Clinical study on self-made Chailing decoction combined with interferon and ribavirin in the treatment of chronic hepatitis C

WU Yifeng

Department of Infectious Diseases， Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine， Foshan   528200， China

[Abstract] Objective To investigate the clinical efficacy of self-made traditional Chinese medicine Chailing decoction combined with interferon and ribavirin in the treatment of chronic hepatitis C. Methods A total of 26 patients who underwent chronic hepatitis C treatment in our hospital from January 2014 to May 2018 were randomly divided into study group and control group. Patients in the control group received peginterferon α-2a and ribavirin treatment， the study group also used the self-made Chinese medicine Chailing decoction treatment. And the two groups of patients were followed up for 6 months. Effectiveness of improving liver stiffness， and the improvement of serum alanine aminotransferase （ALT）， aspartate aminotransferase （AST）， alkaline phosphatase （ALP）， gamma-glutamyltransferase （GGT） indicators， albumin （ALB）， globulin （GLB） and albumin/globulin （A/G） in two groups of patients were compared. Results The effective rate of improvement of liver stiffness in the study group was higher than that in the control group（P<0.05）. The serum levels of ALT， AST， ALP and GGT in the study group were lower than those in the control group， and the difference was statistically significant（P<0.05）. The improvement of ALB， GLB and A/G in the study group was higher than that in the control group， and the difference was statistically significant（P<0.05）. Conclusion In the treatment of chronic hepatitis C patients with peginterferon α-2a and ribavirin， the use of self-made traditional Chinese medicine Chailing decoction can effectively improve the liver stiffness， reduce liver inflammation and improve liver function， which is worthy of clinical promotion.