乳腺癌钼靶X线征象与ER、PR、Her-2表达的相关性分析*

左玮玮 齐赛 刘一航 张建刚 梁日晶 李远

【摘要】 目的：分析乳腺癌鉬靶X线表现和ER、PR以及Her-2因子之间的关系性。方法：对90例乳腺癌患者钼靶X线表现肿块、钙化、病变区密度和结构扭曲与免疫组织化学测定的ER、PR及Her-2表达予以对照分析。结果：ER、PR及Her-2总阳性率分别为60.00%、56.67%及46.67%。有肿块组中ER毛刺肿块组ER基因阳性表达率、PR基因阳性表达率高于非毛刺肿块组，差异有统计学意义（P<0.05）。有钙化组Her-2基因阳性表达率高于无钙化组，差异有统计学意义（P<0.05）。病变区高密度组ER基因阳性表达率、PR基因阳性表达率高于病变区等密度或混杂密度组，差异有统计学意义（P<0.05）。有结构扭曲组ER基因阳性表达率、PR基因阳性表达率低于无结构扭曲组，差异有统计学意义（P<0.05），有结构扭曲组Her-2基因阳性表达率高于无结构扭曲组，差异有统计学意义（P<0.05）。颗粒点状钙化形态组Her-2基因阳性表达率高于分支铸形钙化形态组，差异有统计学意义（P<0.05）。结论：乳腺癌钼靶X线征象与ER、PR和Her-2表达有一定相关性，在一定程度上对ER、PR和Her-2的表达进行反映，可为临床乳腺癌的术前辅助内分泌治疗及预后判定提供更多有价值的信息。

【关键词】 乳腺癌; 钼靶X线; ER; PR; Her-2; 相关性

doi：10.14033/j.cnki.cfmr.2019.12.002 文献标识码 A 文章编号 1674-6805（2019）12-000-04

Analysis of Correlation Between Molybdenum Target X-ray Signs and Expressions of ER，PR and Her-2 in Breast Cancer/ZUO Weiwei，QI Sai，LIU Yihang，et al.//Chinese and Foreign Medical Research，2019，17（12）：-7

【Abstract】 Objective：To analyze the relationship between mammographic features of breast cancer and ER，PR and Her-2 factors.Method：The mammographic features of mass，calcification，density and structural distortion of lesions in 90 breast cancer patients were compared with the expressions of ER，PR and Her-2 determined by immunohistochemistry.Result：The total positive rates of ER，PR and her-2 were 60.00%，56.67% and 46.67%，respectively.The positive expression rate of ER gene and PR gene in the ER hairy tumor group was higher than that in the non-hairy tumor group，and the difference was statistically significant（P<0.05）.The positive expression rate of her-2 gene in the calcified group was higher than that in the non-calcified group，and the difference was statistically significant（P<0.05）.The positive expression rate of ER gene and PR gene in the high-density lesion group was higher than that in the isodensity or confounding density group，and the difference was statistically significant（P<0.05）.The positive expression rate of ER gene and PR gene in the group with structural distortion was lower than that in the group without structural distortion，and the difference was statistically significant（P<0.05）.The positive expression rate of her-2 gene in the group with structural distortion was higher than that in the group without structural distortion，and the difference was statistically significant（P<0.05）.The positive expression rate of her-2 gene in the granular calcification morphological group was higher than that in the branching calcification morphological group，and the difference was statistically significant（P<0.05）.