液基薄层细胞学与活检病理在早期宫颈癌及宫颈上皮内病变中的临床应用价值

于文力

[摘要]目的 探討液基薄层细胞学以及活检病理在早期宫颈癌及宫颈上皮内病变筛查中的临床应用价值。方法 选取2008年1月～2014年12月在我院接受宫颈癌筛查的女性作为研究对象，其中9000例实施液基薄层细胞学检查，891例实施术前活检病理诊断，观察两种方法的诊断结果，并以最终临床诊断结果为依据，分析两种方法的诊断准确率。结果 9000例接受液基薄层细胞学筛查的女性中，根据细胞学与组织学诊断可以相差一级的原则，低度鳞状上皮内病变（LSIL）、宫颈癌前病变（HSIL）以及鳞状细胞癌（SCC）与最终病理诊断结果的符合率分别为31.9%（375/1174）、83.8%（155/185）、100.0%（65/65）；91例接受活检病理诊断的女性中，CIN 1级、CIN 2级、CIN 3级、SCC与最终病理诊断结果的符合率分别为42.8%（80/187）、61.4%（285/464）、71.3%（132/185）、100.0%（65/65），随着分级的升高，诊断符合率相应升高，且各组结果比较，差异有统计学意义（P<0.05）。结论 联合应用液基薄层细胞学和活检病理的手段对早期宫颈癌及宫颈上皮内病变进行诊断，有利于提高患者的诊断效果，能够为其早期治疗提供可靠依据。

[关键词]液基薄层细胞学；活检病理；早期宫颈癌；宫颈上皮内病变；诊断

[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-4721（2016）12（a）-0145-03

Clinical application value of liquid thin-layer cytology and biopsy pathology in early stage of cervical cancer and cervical intraepithelial lesions

YU Wen-li

Maternal and Child Health Care Hospital of Liaoning Province，Shenyang 110005，China

[Abstract]Objective To explore the clinical application value of liquid thin-layer cytology and biopsy pathology in early stage of cervical cancer and cervical intraepithelial lesions.Methods Women with cervical cancer screening from January 2008 to December 2014 in our hospital were selected as research subjects，9000 cases were given liquid based cytology test，891 cases were diagnosed by biopsy pathology before operation，and the diagnosis results of the two methods were observed，finally，based on the final clinical diagnosis results，the diagnostic accuracy of the two methods was analyzed.Results 9000 patients who underwent liquid thin-layer cytology screening of women，according to the principle of cytology and histology diagnosis could differ level，LSIL，HSIL and SCC and final pathological diagnosis coincidence rate was 31.9% （375/1174），83.8% （155/185），100.0% （65/65）.91 patients who underwent biopsy pathologic diagnosis of women，CIN 1，CIN 2，CIN 3 stage，SCC and final pathological diagnosis coincidence rate was 42.8% （80/187），61.4% （285/464），71.3% （132/185），100.0% （65/65），with the increase of classification，the diagnostic accuracy was increased，and there was significant difference in the results among each group （P<0.05）.Conclusion The combination of liquid based cytology and biopsy pathology is a method for the diagnosis of early stage of cervical cancer and cervical intraepithelial lesions，it is beneficial to improve the diagnostic efficiency and can provide a reliable basis for early treatment.

[Key words]Liquid thin-layer cytology；Biopsy pathology；Early cervical cancer；Cervical intraepithelial lesions；Diagnosis