不同剂量瑞舒伐他汀对老年缺血性脑卒中患者血脂的影响
2014-01-24何文绮
何文绮
(上海交通大学医学院附属瑞金医院卢湾分院神经科,上海 200020)
不同剂量瑞舒伐他汀对老年缺血性脑卒中患者血脂的影响
何文绮
(上海交通大学医学院附属瑞金医院卢湾分院神经科,上海 200020)
目的 观察不同剂量瑞舒伐他汀钙对老年缺血性脑卒中患者血脂的影响。方法 随机将50例血脂异常的老年缺血性脑卒中患者分为低剂量瑞舒伐他汀钙治疗组(5 mg)和高剂量瑞舒伐他汀钙治疗组(10 mg),每组25例,分别于治疗前、治疗后8周观察血脂水平变化。结果 治疗8周后,二组患者总胆固醇(TC)、低密度脂蛋白(LDL-C)和三酰甘油(TG)水平均降低(P<0.01),高密度脂蛋白(HDL-C)升高(P<0.01),高剂量治疗组均优于低剂量治疗组(P<0.05)。结论 不同剂量瑞舒伐他汀钙(5、10 mg)都能有效改善老年缺血性卒中患者血脂水平。
缺血性脑卒中;瑞舒伐他汀钙;血脂
脑血管病是目前危害人类健康的三大杀手之一,其中的70%为脑梗死患者,该病具有高发病率、高病死率、高致残率的特点,而动脉粥样硬化是脑卒中的病理学基础,血脂异常尤其是低密度脂蛋白胆固醇(LDL-C)在动脉粥样硬化的发生、发展中起着重要作用。瑞舒伐他汀钙是全新合成的一种他汀类药物,可使低密度脂蛋白胆固醇水平降低65%,高密度脂蛋白胆固醇(HDL-C)水平提高14%,是目前他汀类药物中疗效最好的[1],且安全性和耐受性与现有他汀类药物相似。目前,我国人口老龄化明显,临床治疗中不少都是老年人,本试验对不同剂量的瑞舒伐他汀治疗老年性缺血性脑卒中进行有效性比较。
Effect of Different doses of Rosuvastatin Calcium on Blood-fat in Elderly Patients with Cerebral Ischemic Stroke
HE Wen-qi
(Department of Neurology, Affiliated Ruijin Hospital Branch of Luwan, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China)
Objective To observe the effect of different doses of rosuvastatin calcium on blood-fat in elderly patients with cerebral ischemic stroke. Methods Fifty elderly patients with dyslipidemia were randomly divided into low dose trial group (rosuvastatin calcium 5 mg/d) and high dose trial group (rosuvastatin calcium 10 mg/d), 25 cases patients in each group. Blood lipid was tested before and after 8 weeks respectively. Results 8 weeks after treatment, the two groups of total cholesterol (TC), low density lipoprotein(LDL-C), triglycerides(TG) levels were reduced(P<0.01), high density lipoprotein cholesterol(HDL-C) were raised(P<0.01). High dose treatment group compared with low dose treatment group blood-fat change was more obvious(P<0.05). Conclusions Different doses of rosuvastatin calcium(5, 10 mg) can effectively improve blood lipid level in elderly patients with cerebral ischemic stroke.
Ischemic stroke; Rosuvastatin calcium; Blood-fat
1 资料与方法
R743.33
:B
:1671-8194(2014)31-0053-02