117例伴有副肾动脉的原发性高血压患者的临床特点分析
2023-06-28刘洁王霄安冬梅盛瑛宗刚军
刘洁 王霄 安冬梅 盛瑛 宗刚军
【摘要】 目的:分析117例伴有副肾动脉(ARA)的原发性高血压患者的临床特点。方法:回顾性分析2017年3月-2022年5月中国人民解放军联勤保障部队第九○四医院收治的399例原发性高血压患者的临床资料。根据肾动脉CTA检查结果将患者分为ARA组(n=117)和非ARA组(n=282)。比较两组一般资料、24 h动态血压、心肾功能和肾素-血管紧张素-醛固酮系统(RAAS)指标。结果:399例原发性高血压患者中有117例伴有ARA,占29.32%(117/399)。ARA组的男性比例、日间平均收缩压(DA-SBP)、日间平均舒张压(DA-DBP)、夜间平均收缩压(NA-SBP)、夜间平均舒张压(NA-DBP)、24 h收缩压(24 h-SBP)、24 h舒张压(24 h-DBP)、卧位肾素、立位肾素、卧位醛固酮、立位醛固酮和24 h尿醛固酮均高于非ARA组,差异均有统计学意义(P<0.05)。结论:伴有ARA的患者,其男性比例和血压水平更高,RAAS更活跃。
【关键词】 副肾动脉 原发性高血压 心功能 肾功能 动态血压
Clinical Characteristics of 117 Patients with Essential Hypertension Associated with Accessory Renal Artery/LIU Jie, WANG Xiao, AN Dongmei, SHENG Ying, ZONG Gangjun. //Medical Innovation of China, 2023, 20(11): -112
[Abstract] Objective: To analyze the clinical characteristics of 117 patients with essential hypertension associated with accessory renal artery (ARA). Method: The clinical data of 399 patients with essential hypertension admitted to the 904 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army from March 2017 to May 2022 were analyzed retrospectively. They were divided into ARA group (n=117) and non-ARA group (n=282), according to the results of renal artery CTA. The general data, 24 h ambulatory blood pressure, cardiac and renal function and renin angiotensin aldosterone system (RAAS) indexes were compared between the two groups. Result: 117 patients with ARA out of 399 patients with essential hypertension, accounting for 29.32% (117/399). The male proportion, daily average systolic blood pressure (DA-SBP), daily average diastolic blood pressure (DA-DBP), nighttime average systolic blood pressure (NA-SBP), nighttime average diastolic blood pressure (NA-DBP), 24 h systolic blood pressure (24 h-SBP), 24 h diastolic blood pressure (24 h-DBP), lying renin, standing renin, lying aldosterone, standing aldosterone and 24 h urinary aldosterone in ARA group were higher than those in non-ARA group, the differences were statistically significant (P<0.05). Conclusion: The male proportion and blood pressure in patients with ARA are higher, and the RAAS is more active.
[Key words] Accessory renal artery Essential hypertension Cardiac function Renal function Ambulatory blood pressure
First-author's address: The 904 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Wuxi 214125, China
doi:10.3969/j.issn.1674-4985.2023.11.026
高血壓是引起脑卒中、心肌梗死和心力衰竭等多种心脑血管疾病的主要危险因素之一,也是引起视网膜、肾脏等器官结构和功能损害的重要原因之一[1-2]。原发性高血压占全部高血压疾病的90%以上[3]。高血压人群肾动脉CTA检查常见副肾动脉(ARA)的存在。ARA指不经过肾门而进入肾脏的动脉,多数起自于腹主动脉,从肾的上极或下极直接入肾[4]。ARA血管较细长,走形迂曲,易导致所供肾区血液灌注不足,反射性引起肾交感神经异常激活,进一步激活肾素-血管紧张素-醛固酮系统(RAAS),导致肾血管性高血压[5-6]。关于ARA与原发性高血压之间的关系,既往的研究报道相当有限,且结果存在较大争议。本研究回顾性分析2017年3月-2022年5月中国人民解放军联勤保障部队第九○四医院收治的399例原发性高血压患者的临床资料,以分析ARA的发生率及临床特点。