探析血浆D-二聚体和纤维蛋白原改变在妊娠期糖尿病患者的作用

邹春艳

[摘要] 目的 探讨对妊娠期糖尿病患者实施血浆D-二聚体+纤维蛋白原检测的临床价值。方法 选择该院2017年4月—2019年6月收治的82例妊娠期糖尿病患者作为研究实验组;同时间段选择82名健康孕妇作为研究参照组;针对两组孕妇均展开血浆D-二聚体+纤维蛋白原检测操作，就组间检测结果展开对比。结果 实验组纤维蛋白原水平为（256.29±51.03）mg/dL;血浆D-二聚体水平为（2 312.16±515.25）μg/mL;参照组纤维蛋白原水平为（165.29±51.12）mg/dL;血浆D-二聚体水平为（550.25±152.63）μg/mL;最终发现，实验组妊娠期糖尿病患者纤维蛋白原水平以及D-二聚体水平均高于参照组健康孕妇明显（P<0.05）;实验组失血量为（600.12±42.16）mL;参照组为（400.23±52.22）mL;最终发现，实验组妊娠期糖尿病患者产后失血量高于参照组健康孕妇明显（P<0.05）。结论 妊娠期糖尿病患者于临床接受诊断期间，血浆D-二聚体+纤维蛋白原检测工作的合理开展，可以对患者体内高凝状态以及纤溶状态进行有效判断，对于妊娠期糖尿病患者的病情发展以及疾病预后评估表现出显著价值。

[关键词] 血浆D-二聚体;纤维蛋白原改变;妊娠期糖尿病;检测结果

[中图分类号] R587          [文献标识码] A          [文章编号] 1672-4062（2020）06（a）-0020-03

[Abstract] Objective To explore the clinical value of plasma D-dimer+fibrinogen detection in patients with gestational diabetes. Methods 82 patients with gestational diabetes who were admitted to the hospital from April 2017 to June 2019 were selected as the research experimental group; at the same time， 82 healthy pregnant women were selected as the research reference group; plasma D-II polymer + fibrinogen test operation was developed for both groups of pregnant women， comparing the test results between two groups. Results The fibrinogen level of the experimental group was （256.29±51.03）mg/dL; the plasma D-dimer level was （2 312.16±515.25）μg/mL; the fibrinogen level of the reference group was （165.29±51.12）mg/dL; the plasma D-dimer level was（550.25±152.63）μg/mL; it was finally found that the fibrinogen level and D-dimer level of gestational diabetes patients in the experimental group were significantly higher than that of the healthy pregnant women in the reference group（P<0.05）; The blood loss of the experimental group was （600.12±42.16）mL; the reference group was （400.23±52.22）mL; Finally， it was found that the postpartum blood loss of gestational diabetes patients in the experimental group was higher than that of the healthy pregnant women in the reference group（P<0.05）. Conclusion During the clinical diagnosis of gestational diabetes patients， the reasonable development of plasma D-dimer+fibrinogen detection can effectively judge the hypercoagulable state and fibrinolysis state of the patients， and the disease development and disease prognosis assessment show significant value of gestational diabetes patients.

[Key words] Plasma D-dimer; Fibrinogen changes; Gestational diabetes; Test results

妊娠期糖尿病主要是孕妇在妊娠阶段呈现出体内糖代谢紊乱的现象，属于发病率尤为显著的一种妊娠期并发症[1]。妊娠期糖尿病状态下的患者，会使得自身以及胎儿受到程度不同影响。在人们生活观念以及方式逐渐改变情形下，患有妊娠期糖尿病患者例数增加趋势较为显著，对此确定有效方法就此种疾病给予防治意义显著[2]。人体在呈现出糖代谢紊乱以及脂代谢紊乱的情况后，会对应表现出血液流变学变化以及凝血功能变化的情况。针对人体高凝状态以及继发性纤溶亢进在进行评价期间，血浆D-二聚体以及纤维蛋白原屬于应用率较为显著的特异性指标，通过对此两种指标实时测定，能够对疾病预后进行有效评估，对于临床治疗方案的研究进行充分指导[3]。该次研究将针对2017年4月—2019年6月收治的82例妊娠期糖尿病患者与同时期的82名健康孕妇为研究对象，探究对其实施血浆D-二聚体+纤维蛋白原检测的可行性，以利于妊娠期糖尿病患者病情发展以及疾病预后的有效评估。现报道如下。