尼麦角林联合血栓通注射液治疗缺血性眩晕的效果与安全性观察
2019-11-19房萍
房萍
[摘要] 目的 探讨尼麦角林联合血栓通注射液治疗缺血性眩晕的效果与安全性。 方法 选取我院2016年10月~2018年2月诊治的130例缺血性眩晕患者作为研究对象,将其随机分为对照组和研究组,各65例。对照组在常规治疗基础上给予血栓通注射液进行治疗,研究组在对照组基础上给予尼麦角林进行治疗。对比分析两组患者治疗效果、治疗前后眩晕评分和颅脑动脉血流速度以及不良反应发生情况。 结果 研究组患者临床疗效显著高于对照组(P<0.05);两组患者经过治疗后眩晕症状评分均低于治疗前,但研究组患者治疗后评分低于对照组(P<0.05);治疗后两组患者LVAVm、RVAVm、BAVm均有所提高,其中研究组血流速度快于对照组(P<0.05);研究组不良反应发生情况低于对照组(P<0.05)。 结论 尼麦角林联合血栓通注射液治疗缺血性眩晕疗效显著,安全性高,值得在临床上推广。
[关键词] 尼麦角林;血栓通注射液;缺血性眩晕;安全性
[中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701(2019)25-0054-04
Observation on the effect and safety of nicergoline combined with Xueshuantong injection in the treatment of ischemic vertigo
FANG Ping
Department of Neurology,the Third Hospital of Xuzhou Coal Mining Group, Xuzhou 221011, China
[Abstract] Objective To investigate the efficacy and safety of nicergoline combined with Xueshuantong injection in the treatment of ischemic vertigo. Methods A total of 130 patients with ischemic vertigo who were diagnosed and treated in our hospital from October 2016 to February 2018 were selected as study subjects. They were randomly divided into the control group and the study group, with 65 cases in each group. The control group was given Xueshuantong injection on the basis of conventional treatment. The study group was given nicergoline on the basis of the control group. The therapeutic effects, the vertigo scores before and after treatment, the blood flow velocity of the cranial artery and the occurrence of adverse reactions were compared and analyzed between the two groups. Results The clinical efficacy in the study group was significantly higher than that in the control group(P<0.05); the scores of vertigo symptoms after treatment in the two groups were lower than those before treatment, but the scores in the study group after treatment were lower than those in the control group(P<0.05); after treatment, LVAVm, RVAVm and BAVm were improved in both groups, and the blood flow velocity in the study group was faster than that in the control group(P<0.05); the incidence of adverse reactions in the study group was lower than that in the control group(P<0.05). Conclusion Nicergoline combined with Xueshuantong injection is significantly effective in the treatment of ischemic vertigo, and the safety is high, which is worthy of clinical promotion.
[Key words] Nicergoline; Xueshuantong injection; Ischemic vertigo; Safety
眩暈症是临床常见的慢性疾病,其主要是因为人体自身对空间判断错位而引起的位置性错觉。其中缺血性眩晕是椎-基底动脉系统供血不足而引发的缺血性脑血管疾病,占脑血管疾病的15%[1,2]。由于缺血性眩晕反复性强、复发率高且起病急等特点,严重影响患者的生活和生命安全[3]。因此,寻找合理且有效的治疗缺血性眩晕的手段显得尤为关键。目前,临床上治疗方案较多但缺乏统一标准,常见的治疗缺血性眩晕的药物有血栓通注射液、法舒地尔、天麻素以及尼麦角林等,其中血栓通注射液主要作用为扩张血管,改善机体内血液循环,且为中药制剂,副作用较小;尼麦角林是常用于治疗急慢性血管性功能不全,能够有效改善缺血性眩晕患者反应迟钝和抑郁等后遗症[4]。目前将这两种药物联合使用的报道并不多。本文就我院2016年10月~2018年2月诊治的130例缺血性眩晕患者进行回顾分析,取得可靠的结论,现报道如下。
综上所述,尼麦角林联合血栓通注射液治疗缺血性眩晕患者治疗效果显著,有效改善颅脑动脉供血情况,促进脑部细胞新陈代谢,并且不良反应较小,为治疗缺血性眩晕提供有效参考。
[參考文献]
[1] 陈星,欧阳天斌,朱华麟,等. 盐酸培他啶联合盐酸异丙嗪注射液治疗眩晕症患者的疗效[J]. 中国生化药物杂志, 2016,36(2):79-81.
[2] 邓华,张选国. 后循环缺血性眩晕患者中医体质分析[J].陕西中医,2017,38(8): 1008-1009.
[3] 杨玉佩. 法舒地尔联合血栓通治疗椎基底动脉供血不足性眩晕的疗效[J]. 中国使用神经疾病杂志,2017,20(14):34-35.
[4] 周立,杜林,吴克礼,等. 尼麦角林对缺血性脑卒中后认知障碍及血清脑源性神经营养因子、神经生长因子和神经元特异性烯醇化酶的影响[J]. 血栓与止血学,2017,23(5):729-732.
[5] 王振英,陈国锋,李灶容,等. 良性阵发性位置性眩晕患者的生活质量评估及疗效评价[J]. 中国当代医药,2017, 24(2): 95-97.
[6] 史一丰,茅跃平. 脑安胶囊对老年后循环缺血性眩晕病人的临床疗效[J]. 实用老年医学,2017,9(9):855-857.
[7] 司铁彬. 天麻素注射液联合血栓通注射液对后循环缺血性眩晕的治疗效果[J]. 中国卫生工程学,2017,16(6):825-829.
[8] 张丛林. 血栓通联合丹参川芎嗪治疗椎-基底动脉供血不足性眩晕的疗效及对血液流变学的影响[J]. 河北医药,2017,39(1):127-130.
[9] 裴裴,卫汨,曹雄彬,等. 尼麦角林联合舒血宁注射液治疗眩晕症的临床效果及对TCD参数的影响[J]. 中国医药导报,2018,15(8):68-71.
[10] 岳亚男,郑晨星,王宝亮. 天麻素联合血栓通治疗后循环缺血性眩晕38例[J]. 光明中医,2017,32(3):112-115.
[11] 刘雅芳,黄咏梅,戴军,等. 丁苯酞联合前列地尔注射液治疗后循环缺血性眩晕的临床效果[J]. 中国医药导报,2017,14(18):145-148.
[12] 王妮. 血栓通注射液对急性冠脉综合征患者介入术后血脂、炎症因子及内皮功能的影响[J]. 现代中西医结合杂志,2017,26(7): 728-730.
[13] 盛守权,乔启家,方茹. 尼麦角林联合长春西汀治疗急性脑梗死的临床研究[J]. 现代药物与临床,2018,33(8):1884-1887.
[14] 杨廷海,张丽萍,殷建保,等. 脉络宁口服液联合尼麦角林治疗血管性痴呆临床研究[J]. 中西医结合心脑血管病杂志,2017,15(16): 2053-2055.
[15] 陈国军,张燕柳,张惠莉,等. 尼麦角林联合高压氧治疗血管性认知功能障碍疗效观察[J]. 中华老年医学杂志,2015,34(4):359-361.
[16] 黄斯倩,颜小均. 舒血宁注射液联合前列地尔注射液治疗糖尿病周围血管病变的效果[J]. 中国医药导报,2016,13(15):158-161.
[17] 王子亮. 补阳还五汤联合尼麦角林对脑梗死病人血清氧自由基和颅内血流的影响[J]. 中西医结合心脑血管病杂志,2018,2(11):1605-1607.
(收稿日期:2019-03-09)