泮托拉唑辅助治疗消化性溃疡合并上消化道出血的临床效果

付丽园 吴智 谌丽华

[摘要]目的 探讨泮托拉唑輔助治疗消化性溃疡合并上消化道出血的临床效果。方法 选取2017年1～12月我院收治的100例消化性溃疡合并上消化道出血患者作为研究对象，按照随机数字表法将其分成两组，分别为对照组（50例）和研究组（50例）。对照组患者给予奥美拉唑治疗，研究组患者给予奥美拉唑联合泮托拉唑辅助治疗。比较分析两组患者的临床治疗效果、治疗前后不同时间的呕血次数及黑便次数，比较两组患者的并发症发生情况。结果 研究组患者的临床治疗总有效率为96.00%，对照组患者的临床治疗总有效率为78.00%，研究组患者的临床治疗总有效率高于对照组，差异有统计学意义（P<0.05）。研究组患者治疗前的呕血次数为（2.98±1.21）次，黑便次数为（2.21±1.02）次，对照组患者治疗前的呕血次数为（3.02±1.20）次，黑便次数为（2.20±1.03）次，两组治疗前的呕血次数、黑便次数比较，差异无统计学意义（P>0.05）;研究组患者治疗后1～3 d的呕血次数为（1.30±0.80）次，黑便次数为（1.40±0.56）次，对照组患者治疗后1～3 d的呕血次数为（1.85±0.95）次，黑便次数为（1.75±0.65）次，两组患者治疗后1～3 d的呕血次数、黑便次数均少于治疗前，差异有统计学意义（P<0.05），研究组患者治疗后1～3 d的呕血次数、黑便次数均少于对照组，差异有统计学意义（P<0.05）;两组患者治疗后4～7 d均未发生呕血，两组患者治疗后4～7 d的呕血次数比较，差异无统计学意义（P>0.05）;研究组患者治疗后4～7 d的黑便次数为（0.21±0.10）次，对照组患者治疗后4～7 d的黑便次数为（0.32±0.12）次，研究组患者治疗后4～7 d的黑便次数少于对照组，差异有统计学意义（P<0.05）。研究组患者的并发症总发生率为4.00%，对照组患者的并发症总发生率为18.00%，研究组患者的并发症总发生率低于对照组，差异有统计学意义（P<0.05）。结论 消化性溃疡合并上消化道出血应用泮托拉唑辅助治疗的临床效果确切。

[关键词]泮托拉唑;消化性溃疡;上消化道出血;临床效果

[中图分类号] R632.1          [文献标识码] A          [文章编号] 1674-4721（2019）8（c）-0060-04

[Abstract] Objective To explore the clinical effect of Pantoprazole in the adjuvant treatment of peptic ulcer complicated with upper gastrointestinal hemorrhage. Methods One hundred patients with peptic ulcer complicated with upper gastrointestinal hemorrhage treated from January to December 2017 were enrolled as subjects and divided into the control group （50 cases） and the study group （50 cases） according to the random number table method. Patients in the control group were given Omeprazole， and those in the study group were additionally given Pantoprazole. The clinical effects， times of haematemesis and melena before treatment and at different time after treatment， and the incidence of complications were compared between the two groups. Results The overall effective rate in the study group was 96.00%， significantly higher than the 78.00% in the control group （P<0.05）. The times of haematemesis was （2.98±1.21） in the study group before treatment， and that of melena was （2.21±1.02）， which was （3.02±1.20） and （2.20±1.03） in the control group， showing no significant difference between two groups （P>0.05）. The times of haematemesis was （1.30±0.80） in the study group at 1-3 d after treatment and that of melena was （1.40±0.56）， which was （1.85±0.95） and （1.75±0.65） in the control group at 1-3 d after treatment， the times of haematemesis and melena were significantly fewer than those before treatment in both groups （P<0.05）， and those in the study group were significantly fewer than those in the control group （P<0.05）. The times of haematemesis was 0 in the two groups at 4-7 d after treatment， showing no significant difference between two groups （P>0.05）. The times of melena was （0.21±0.10） in the study group at 4-7 d after treatment， and that of the control group was （0.32±0.12）， which was significantly fewer in the study group （P<0.05）. The total incidence of complications was 4.00% in the study group and 18.00% in the control group， the total incidence of complications in the study group was lower than that in the control group， and the difference was statistically significant （P<0.05）. Conclusion The clinical effect of Pantoprazole adjuvant therapy for peptic ulcer combined with upper gastrointestinal bleeding is definite.