LEEP刀联合rb-bFGF凝胶在宫颈上皮内瘤变中的治疗价值

蔡美卿　邱惠君

【摘要】 目的 探讨高频电波刀（LEEP刀）联合重组牛碱性成纤维细胞生长因子（rb-bFGF）凝胶在宫颈上皮内瘤变中的应用价值。方法 100例宫颈上皮内瘤变患者， 根据随机数字表法分为研究组和对照组， 各50例。研究组行LEEP刀联合rb-bFGF凝胶治疗， 对照组行LEEP刀治疗。比较两组临床疗效、创面愈合情况及术后并发症发生情况。结果 研究组的临床治疗总有效率98.00%（49/50）高于对照组的84.00%（42/50）， 差异有统计学意义（P<0.05）。研究组创面止血结痂初步愈合时间（8.09±2.37）d短于对照组的（17.74±3.47）d， 差异有统计学意义（P<0.05）。研究组阴道出血量少于对照组， 阴道出血持续时间短于对照组， 差异均有统计学意义（P<0.05）。研究组并发症发生率2%（1/50）低于对照组的16%（8/50）， 差异有统计学意义（P<0.05）。結论 宫颈上皮内瘤变患者行LEEP刀联合rb-bFGF凝胶治疗利于促进患者术后创面愈合， 提高临床疗效， 降低术后并发症发生率， 值得临床推广。

【关键词】 宫颈上皮内瘤变;高频电波刀;牛碱性成纤维细胞成长因子凝胶

DOI：10.14163/j.cnki.11-5547/r.2019.23.005

Therapeutic value of LEEP knife combined with rb-bFGF gel in cervical intraepithelial neoplasia   CAI Mei-qing， QIU Hui-jun. Lufeng Peoples Hospital， Lufeng 516500， China

【Abstract】 Objective   To discuss the practical value of loop electrosurgical excisional procedure （LEEP） knife combined with recombinant bovine basic fibroblast growth factor （rb-bFGF） gel in cervical intraepithelial neoplasia. Methods   A total of 100 cervical intraepithelial neoplasia patients were divided by random number table method into research group and control group， with 50 cases in each group. The research group was treated with LEEP knife combined with rb-bFGF gel， and the control group was treated with LEEP knife. Comparison was made on clinical efficacy， wound healing condition and occurrence of postoperative complications between the two groups. Results   The research group had higher total effective rate of clinical treatment as 98.00%（49/50） than 84.00%（42/50） in the control group， and the difference was statistically significant （P<0.05）. The research group had shorter preliminary healing time of wound hemostasis and scab formation as （8.09±2.37） d than （17.74±3.47） d in the control group， and the difference was statistically significant （P<0.05）. The research group had less amount of vaginal hemorrhage than the control group and shorter duration of vaginal bleeding than the control group. Their difference was statistically significant （P<0.05）. The research group had lower incidence of complications as 2%（1/50） than 16%（8/50） in the control group， and the difference was statistically significant （P<0.05）. Conclusion   LEEP knife combined with rb-bFGF gel treatment is helpful to promote wound healing of patients with cervical intraepithelial neoplasia， improve clinical efficacy， and reduce the incidence of complications. It is worthy of clinical promotion.