兰索拉唑与泮托拉唑治疗胃溃疡的临床效果及安全性比较

张长武

[摘要]目的 探讨兰索拉唑与泮托拉唑治疗胃溃疡的临床效果及安全性。方法 选取2015年1月～2018年10月我院收治的56例胃溃疡患者作为研究对象，按照随机分组方法分为实验组（28例）与对照组（28例）。实验组采用兰索拉唑静脉滴注治疗，对照组采用泮托拉静脉滴注治疗。比较两组的临床疗效、临床症状积分、不良反应发生情况。结果 实验组的治疗总有效率（96.43%）高于对照组（75.00%），差异有统计学意义（P<0.05）。实验组的临床症状积分为（1.52±0.28）分，低于对照组的（2.74±0.46）分，差异有统计学意义（P<0.05）。两组的不良反应总发生率比较，差异无统计学意义（P>0.05）。结论 兰索拉唑与泮托拉唑治疗胃溃疡能够明显改善患者的临床症状，快速缓解其疼痛，临床效果显著。兰索拉唑在临床疗效、临床症状积分、不良反应方面更优于泮托拉唑，安全性高，值得临床推广。

[关键词]兰索拉唑;泮托拉唑;胃溃疡;临床疗效

[中图分类号] R573.1          [文献标识码] A          [文章编号] 1674-4721（2019）7（c）-0073-03

[Abstract] Objective To explore the clinical effect and safety of Lansoprazole and Pantoprazole in the treatment of gastric ulcer. Methods All of 56 patients with gastric ulcer admitted to our hospital from January 2015 to October 2018 were selected as the study subjects. According to the method of random grouping， they were divided into the experimental group （28 cases） and control group （28 cases）. The experimental group was treated with Lansoprazole for intravenous drip， while the control group was treated with Pantoprazole for intravenous drip. The clinical efficacy， clinical symptom score and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the experimental group （96.43%） was higher than that of the control group （75.00%）， and the difference was statistically significant （P<0.05）. The score of clinical symptoms in the experimental group was （1.52±0.28） points， which was lower than that in the control group for （2.74±0.46） points， and the difference was statistically significant （P<0.05）. There was no significant difference in the total incidence of adverse reactions between the two groups （P>0.05）. Conclusion Lansoprazole and Pantoprazole in the treatment of gastric ulcer can significantly improve the clinical symptoms of patients， quickly relieve the pain of patients， the clinical effect is significant. Lansoprazole is superior to Pantoprazole in clinical efficacy， clinical symptom score and adverse reactions， its safety is high and it is worthy of clinical promotion.

[Key words] Lansoprazole; Pantoprazole; Gastric ulcer; Clinical efficacy

胃潰疡（gastric ulcer）是临床消化系统最常见的疾病之一，主要以腹痛、腹胀、反酸、胃脘部烧灼感等为症状，周期性、节律性疼痛是其最典型的临床症状。其发病机制主要是胃酸、胃蛋白酶的侵袭作用与胃黏膜的保护作用平衡失调引起，幽门螺杆菌感染、非甾体消炎药、胃排空异常是其常见的致病因素。此外，精神心理因素、应激、不良生活习惯亦容易导致溃疡的发生[1-2]。抑制胃酸分泌是治疗胃溃疡最关键的措施。近年来，随着抑酸药物的发展，越来越多的药物被应用于临床，尤其是质子泵抑制剂，如泮托拉唑、奥美拉唑、兰索拉唑、雷贝拉唑等[3-4]。为探讨胃溃疡的治疗，为临床提供参考，本研究拟对我院住院的消化性溃疡患者采用兰索拉唑与泮托拉唑治疗，并取得较好的效果，现报道如下。