参麦注射液在头颈部肿瘤放疗中减轻放射性不良反应的临床观察

陈飞　余婷婷　刘晓安

[摘要] 目的 观察参麦注射液在头颈部肿瘤放疗中减轻放射性不良反应的临床效果。 方法 分析2015年3月～2017年3月我院收治的128例头颈部肿瘤放疗患者的临床资料，计算总有效率；总的放疗2～4级急性损伤发生率、中重度疼痛发生率、生活质量降低发生率；放疗完成1个月后的生活质量改善发生率。 结果 观察组患者治疗的总有效率[93.75%（60/64）]明显高于对照组[81.25%（52/64）]，差异具有统计学意义（P<0.05）；总的放疗2～4级急性损伤发生率明显低于对照组，差异具有统计学意义（P<0.05），中重度疼痛发生率31.25%（20/64）明显低于对照组的68.75%（44/64），差异具有统计学意义（P<0.05）；放疗完成1个月后观察组患者的生活质量改善发生率93.75%（60/64），明显高于对照组62.50%（40/64），差异具有统计学意义（P<0.05），观察组患者生活质量降低发生率0%（0/64），明显低于对照组的15.63%（10/64），差异具有统计学意义（P<0.05）。 结论 参麦注射液在头颈部肿瘤放疗中减轻放射性不良反应的临床效果显著。

[关键词] 参麦注射液；头颈部肿瘤放疗；临床疗效；放射性不良反应

[中图分类号] R273 [文献标识码] B [文章编号] 1673-9701（2017）28-0095-03

[Abstract] Objective To observe the clinical effect of Shenmai injection on reducing radioactive adverse reactions in head and neck tumor radiotherapy. Methods The clinical data of 128 patients with head and neck tumor radiotherapy who were admitted to our hospital from March 2015 to March 2017 were statistically analyzed. The total effective rate was calculated； total incidence rate of grade 2-4 acute injury by radiotherapy； incidence rate of moderate to severe pain； incidence rate of quality of life reduction； incidence rate of improvement in quality of life after one month of radiotherapy were compared. Results The total effective rate was 93.75%（60/64） in the observation group， which was significantly higher than that of 81.25%（52/64） in the control group，the difference was significant（P<0.05）； the total incidence rate of grade 2-4 acute injury was significantly lower than that in the control group，the difference was significant（P<0.05）. The incidence rate of moderate to severe pain was 31.25%（20/64）， which was significantly lower than that of 68.75%（44/64） in the control group， the difference was significant（P<0.05）； the improvement rate of quality of life in the observation group was 93.75%（60/64）， the difference was significant， which was significantly higher than that of 62.50%（40/64） in the control group， the difference was significant（P<0.05）. The incidence rate of life quality reduction was 0%（0/64） in the observation group， which was significantly lower than that of 15.63%（10/64） in the control group， the difference was significant（P<0.05）. Conclusion Shenmai injection in the head and neck tumor radiotherapy has a significant clinical effect of reducing radioactive adverse effects.

[Key words] Shenmai injection； Head and neck tumor radiotherapy； Clinical efficacy； Radioactive adverse reactions

放射治療为头颈部恶性肿瘤重要的治疗手段，虽然放疗的设备和技术有了长足的进步，如适形、调强、立体定向放疗，但无法避免放疗的毒副反应及并发症的发生，因此放疗过程中出现的不良反应常使患者中断治疗，使疗效降低，病程延长，患者生存质量严重下降。祖国医学认为放射线是火热阳毒之邪，可伤阴耗气，灼伤津液，而参麦注射液属于纯中药抗癌药物，主要功效为清热解毒、镇痛等[1]。本研究对2015年3月～2017年3月我院收治的128例头颈部肿瘤放疗患者的临床资料进行统计分析，观察参麦注射液在头颈部肿瘤放疗中减轻放射性不良反应的临床效果，现报道如下。endprint