他克莫司治疗原发性肾病综合征的临床分析

魏建波+宁芳芳+卢勤燕

[摘要]目的 探讨他克莫司治疗原发性肾病综合征的临床疗效情况。方法 选取2011年2月～2015年3月我院肾内科收治原发性肾病综合征患者30例临床资料，依据治疗措施不同进行分组，对照组（环磷酰胺联合醋酸泼尼松治疗）15例和他克莫司组（他克莫司联合醋酸泼尼松治疗）15例。比较两组原发性肾病综合征患者治疗前和治疗6个月后血清白蛋白、肌酐、胆固醇、三酰甘油、尿蛋白定量情况以及两组患者临床疗效情况。结果 两组原发性肾病综合征患者治疗前血清白蛋白、肌酐、胆固醇、三酰甘油、尿蛋白定量比較，差异无统计学意义（P>0.05），对照组和他克莫司组治疗6个月后血清白蛋白均高于治疗前，肌酐、胆固醇、三酰甘油、尿蛋白定量均低于治疗前，他克莫司组治疗6个月后血清白蛋白均高于对照组，肌酐、胆固醇、三酰甘油、尿蛋白定量均低于对照组，他克莫司组原发性肾病综合征患者治疗缓解率高于对照组，差异有统计学意义（χ2=7.65，P<0.05）。结论 他克莫司治疗原发性肾病综合征患者临床症状改善明显，缓解率高，值得临床推广应用。

[关键词]他克莫司；原发性肾病综合征；白蛋白；肌酐；尿蛋白定量

[中图分类号] R692 [文献标识码] A [文章编号] 1674-4721（2016）12（b）-0129-03

The clinical analyzing of treatment primary nephrotic syndrome by tacrolimus

WEI Jian-bo NING Fang-fang LU Qin-yan

Department of Nephrology，the Sixth Affiliated Hospital of Guangzhou Medical University，Qingyuan 511518，China

[Abstract]Objective To explore the clinical effects of treatment primary nephrotic syndrome by tacrolimus.Methods 30 cases clinical data of primary nephrotic syndrome patients in our hospital department of nephrology from February 2011 to March 2015 were selected，and divided into two groups by different treatment methods，the control group （cytoxan compared with prednisone acetate treatment）15 cases and the Tacrolimus group （prednisone acetate compared with tacrolimus treatment）15 cases.The serum albumin，creatinine，cholesterol，triglyceride，urine protein quantitation of two groups primary nephrotic syndrome patients before treatment and after treatment 6 moths were compared，clinical curative effect of two groups primary nephrotic syndrome patients were compared.Results The serum albumin，creatinine，cholesterol，triglyceride，urine protein quantitation of two groups primary nephrotic syndrome patients before treatment were no significant difference（P>0.05），the serum albumin of control group and Tacrolimus group after treatment 6 moths were higher than before treatment；the creatinine，cholesterol，triglyceride，urine protein quantitation were lower than before treatment；the serum albumin of Tacrolimus group after treatment 6 moths was higher than that of control group；the creatinine，cholesterol，triglyceride，urine protein quantitation were lower than that of control group；the remission rate of treatment group was higher than that of control group，the differences were significant（χ2=7.65，P<0.05）.Conclusion The clinical symptoms of treatment primary nephrotic syndrome by tacrolimus is obviously，remission rate is high，it is worth to be used.

[Key words]Tacrolimus；Primary nephrotic syndrome；Albumin；Creatinine；Urine protein quantitation