复方皂矾丸在恶性肿瘤患者化疗后骨髓造血功能中的保护及机制

孙成晖　孙钦文　严伟红　韩明锦　柳宝

【摘要】 目的 探究复方皂矾丸在恶性肿瘤患者化疗后骨髓造血功能中的保护及机制。方法 90例恶性肿瘤患者， 随机分为参照组与研究组， 各45例。对两组患者实施化疗后， 参照组给予联合鲨肝醇片与利血生片进行治疗， 研究组则使用复方皂矾丸进行治疗。比较两种治疗方法对患者化疗后骨髓造血功能的保护作用。结果 实施化疗后第21天， 研究组患者血小板≥100×109/L的患者占100.00%、血红蛋白≥90 g/L的患者占100.00%、中性粒细胞≥1.5×109/L的患者占86.67%， 优于参照组的77.78%、73.33%、68.89%， 差异具有统计学意义（P<0.05）。研究组出血率与感染率分别为11.11%和31.11%， 参照组出血率与感染率分别为35.56%和53.33%， 研究组患者化疗后出血率及感染率低于参照组， 差异具有统计学意义（P<0.05）。结论 恶性肿瘤患者化疗后采用复方皂矾丸进行治疗， 效果显著， 对其骨髓造血功能起到良好的保护作用， 药效学效应以及临床疗效均得到较大程度的提升， 值得推广应用。

【关键词】 复方皂矾丸；恶性肿瘤；骨髓造血功能；保护机制

DOI：10.14163/j.cnki.11-5547/r.2016.32.053

【Abstract】 Objective To investigate protection mechanism of compound Zaofan pills in bone marrow hematopoietic function after chemotherapy for malignant tumor patients. Methods A total of 90 patients with malignant tumor were randomly divided into control group and research group， with 45 cases in each group. After chemotherapy in both groups， the control group received batilol tablets combined with leucogen tablets for treatment， and the research group received compound Zaofan pills for treatment. Comparison was made on protective effects between the two treatment measures on bone marrow hematopoietic function after chemotherapy. Results After 21 d of chemotherapy， cases with blood platelet ≥100×109/L in the research group accounted for 100.00%， cases with hemoglobin ≥ 90 g/L accounted for 100.00%， and cases with neutrophil ≥1.5×109/L accounted for 86.67%， which were all better than 77.78%， 73.33% and 68.89% in the control group， and their difference had statistical significance （P<0.05）. The research group had hemorrhage rate and infection rate respectively as 11.11% and 31.11%， and the control group had hemorrhage rate and infection rate respectively as 35.56% and 53.33%. The research group had lower hemorrhage rate and infection rate after chemotherapy than the control group， and the difference had statistical significance （P<0.05）. Conclusion Implement of compound Zaofan pills after chemotherapy for malignant tumor shows excellent effects. This method shows good protective effect for bone marrow hematopoietic function， along with remarkable improvement of pharmacodynamic effect and clinical effect. It is worth promoting and applying.

【Key words】 Compound Zaofan pills； Malignant tumor； Bone marrow hematopoietic function； Protection mechanism

恶性肿瘤作为一种临床常见疾病， 具有类型多、发病率高等特点[1]。通常情况下， 患者患病后无明显症状， 而当身体出现明显疼痛感时再就医， 一般已为中晚期， 错失了治疗的最佳时机[2]。现阶段较为常见的治疗恶性肿瘤的方法就是化疗。然而， 研究表明少数患者在化疗后极易出现造血功能损伤， 進而产生毒性反应[3]， 对患者的预后产生不利影响。本院就复方皂矾丸在恶性肿瘤患者化疗后骨髓造血功能中的保护及机制展开研究， 取得了较为理想的效果， 现报告如下。