Physiotherapeutic techniques used in the management of patients with peripheral nerve injuries

Physiotherapeutic techniques used in the management of patients with peripheral nerve injuries

Peripheral nerve injuries af ect a wide range of functional, manual and social function, and frequently lead to constant disabilities. After complete transection of nerve, axonal degeneration process gives rise to a variety of symptoms including hyperesthesia, reduced or altered sensation, pain and atrophy (Lee and Wolfe, 2000). With an array of choices for surgical and treating peripheral nerve injuries, there is also, a lot of new, coherent strategies on rehabilitation and physiotherapy protocols - which should be indispensable after injury. Physiotherapy, with a view to compensate dysfunctions relieves in sensory symptoms and creates grater neuroplasticital potential, forms essential part of the treatment for people after peripheral nerve injuries (Inoue et al., 2003).

In the present paper we present the physiotherapeutic methods, protocols, and strategy currently used for initiation and support of peripheral nerve regeneration after injuries.

Kinetic therapy in peripheral nerve injuries: Impact of kinetic therapy on peripheral nerve repair after its damage is mostly determined by the time required for regeneration of nerve f bers as well as for muscle reinnervation. Stress put on a paralyzed muscle through stretching or strengthening delays, and may even prevent full nerve recovery, and such treatment should not be started until the late stage of nerve regeneration, when progressive strength return can be seen. After injury of the nerve, physiotherapeutic methods are dedicated to eliminate paresis and to restore normal function of muscles as well as to improve circulation and following energetic supply to the tissues. Table 1 presents an overview of the current methods most commonly used in physiotherapy after peripheral nerve injury.

Electrostimulation: Electric stimulation plays an important role in the treatment of various neuromuscular dysfunctions. With a wide range of applications and the possibility of combining this method with others, it is considered as one of the most ef ective. There are many types and ways of electrostimulation which differ one from another with the technical embodiment. The most common method is transcutaneous electrical nerve stimulation (TENS), which consists of transcutaneous stimulation pulses of electric current with a frequency of 90–130 Hz.

Chen et al. (2001) showed that percutaneous electric stimulation of 2 Hz frequency enhanced the mean values of the axon density, blood vessel number, blood vessel area and percentage of blood vessel area in total nerve area in injured rat sciatic nerve. As studies show, stimulation current of low frequency (20 Hz) for 1 hour a day for 2 weeks after the injury shortens the period of axonal outgrowth of three nerve bundles through the implanted graft (Al-Majed et al., 2000; Gordon et al., 2003. It also showed that electrical stimulation has a positive inf uence on regeneration processes by stabilizing the cholinergic receptors at the neuromuscular junction.

Electroacupuncture is a simple method of indirect application of an electrical stimulation to injured nerve. Pomeranz and Campbell (1993) revealed that the regeneration of injured nerve was enhanced by continuous electrical stimulation at the site of the injury via chronically implanted electrodes. However, Inoue et al. (2003) showed that it is unclear whether electroacupuncture enhanced the axonal regeneration processes. Most frequently used patterns of electrical stimulation of peripheral nerve trauma are presented in Table 2.

Magnetotherapy: For the treatment of damaged peripheral nerve, a pulsed low frequency magnetic f eld can also be applied. Magnetic f eld therapy has well-known ef ects on enhancing enzymatic activity, oxy-reductive processes and better blood circulation what results in better oxygenation and conduction characteristics of regenerating peripheral nerves. These mechanisms base on the inf uence of magnetic f eld on liquid-crystal structure of many membranes and cell organelles resulting in ion-channels transmission changes. Alteration in intra- or extracellular ion distribution leads to changes in electric potentials in organella membranes as well as in cellular membranes of living biological systems. Magnetic stimulation enhances the regeneration of nerve f bers, as the nerve conductivity increases as well as the amplitude of the action potential (Negredo et al., 2004; Mert et al., 2006). The pulsed electromagnetic f eld (PEMF) has a high clinical value, as applied immediately after peripheral nerve injury - shortens the duration of functional defects (Mert et al., 2006). Unlike electrical stimulation, magnetic stimulation carries no risk of infection due to electrodes pinned around the wound, and it is completely painless, even in patients with well-preserved sensation. Therapeutic ef ects of PEMF and CEMF in the case of peripheral nerve damage are comparable and may be used complementarily (Bannaga et al., 2006).

Spatial magnetic field generator is one of most recent achievements among the magnetostimulators. Prototype generates magnetic f eld through 3 pairs perpendicularly arranged magnetic coils. This allows for the interference of f elds and results in obtaining the rotational magnetic f eld focused in small area. This new method may be more ef ective than other widely used techniques of magnetostimulation and magnetotherapy, as shown in animal experiments where strong spatial alternating magnetic f eld exerted positive ef ect on peripheral nerve regeneration. This improvement was found in all experimental groups, with best outcome observed in group exposed to the strongest magnetic f eld. Also dorsal root ganglion survival rate and nerve regeneration intensity were signif cantly higher in the group treated with the strongest f eld (Suszyński et al., 2014). Magnetic f elds used in treatment of peripheral nerve injury are shown in Table 3.

Bio-laser stimulation: For the treatment of peripheral nerve injury, low energy biostimulation lasers are used, applied in the way of pulsatile (905 nm), continuous (808 nm), or pulsing-constant rays. Laser therapy increases the formation of ATP, and the energy of the ATP hydrolysis can be used by nerve cell to restore normal transmembrane potential, which facilitates the generation of electrical impulses and thereby restoring nerve conduction (bioelectric ef ect). Application of laser beams improves microcirculation and hence nutrition and regeneration of nerve cells – bio-stimulation ef ect – and increases the release of endorphins and the concentration of neurotransmitters in the synapses – analgetic ef ect.

Laser radiation can also be used to rejoin the nerve stumps (Lanre method – laser-assisted nerve repair). Studies evaluating the use of this method show comparable or even more ef ective reconstruction then surgical treatment. Less scar formation is observed in the site of anastomosis, which creates favorable conditions for the regeneration of nerve f bers (Huang and Huang, 2006). There are also promising results of the coupled use of

fiber membranes or Gore-Tex™ with laser beams. This aids in assembling the ends of the nerve, and af ects the speed and ef ciency of the regeneration process. Application of laser irradiation (Ga-As laser) in the site of the anastomosis inhibits the degeneration process, accelerate remyelination, and nerve function recovery (Bae et al., 2004; Miloro et al., 2002).

Table 1 The most commonly used methods of kinetic therapy in peripheral nerve damage

Table 2 The most commonly used patterns of electrical stimulation of peripheral nerves after injury

Table 3 The use of magnetic f elds in the treatment of peripheral nerve injuries

One of the major complications of peripheral nerve damage is the formation of a neuroma at the end of the proximal stump. Biostimulation with CO2or Neodymium-Yag lasers reduces the risk of its formation, or at least alleviates severe pain caused by the formation of a neuroma (Kuzbari et al., 1996).

Therapeutic use of ultrasounds (US) gave some promising results in animal experiment (Raso et al., 2005). However, before this technique might be implemented in human therapy, it is indispensable to precisely elucidate the inf uence of the US on nervous tissue, as well as to determine the most ef ective and safest therapeutic protocol that could be used in clinical practice.

In general, there is a lack of randomized, good quality data representing results of clinical application of particular therapeutic methods using standardized dozymetry. Current research encompassing treatment and intervention in nerve injuries is limited, consisting mostly of descriptive and exploratory studies. Especially nonsurgical or post-surgical physical therapy is poorly understood by many physical therapists and even physicians, many clinicians fail to recognize that such nerves often need considerable time to regenerate.

Krzysztof Suszyński, Wiesław Marcol*, Dariusz Górka

Department of Physiotherapy, Department of Sports Medicine and Physiology of Physical Ef ort, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland (Suszyński K, Górka D) Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland (Marcol W)

*Correspondence to: Wiesław Marcol, M.D., Ph.D., wmarcol@tlen.pl.

Accepted: 2015-09-06

orcid: 0000-0002-8914-7273 (Wiesław Marcol)

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10.4103/1673-5374.170299 http://www.nrronline.org/

Suszyński K, Marcol W, Górka D (2015) Physiotherapeutic techniques used in the management of patients with peripheral nerve injuries. Neural Regen Res 10(11):1770-1772.