沙丁胺醇与异丙托溴胺联合雾化吸入治疗支气管哮喘急性发作的临床效果观察
2015-01-30黄燕虹
黄燕虹
[摘要]目的 探讨沙丁胺醇与异丙托溴胺联合雾化吸入治疗支气管哮喘急性发作的临床疗效。 方法 选取2011年12月~2013年12月在我院进行治疗的82例支气管哮喘急性发作患者,随机分为观察组和对照组,对照组给予常规治疗和沙丁胺醇雾化吸入治疗,观察组在对照组治疗的基础上,加用异丙托溴胺雾化吸入进行治疗,比较两组的疗效。 结果 观察组显效率为61.90%,总有效率为95.24%,对照组显效率为30.00%,总有效率为77.50%,两组差异有统计学意义(P<0.05)。 结论 沙丁胺醇与异丙托溴胺联合雾化吸入治疗支气管哮喘急性发作,可显著增加治疗效果。
[关键词]沙丁胺醇;异丙托溴胺;氧驱动雾化吸入;支气管哮喘急性发作
[中图分类号]R725.6 [文献标识码]B [文章编号]2095-0616(2014)20-145-04
The clinical effect of salbutamol and ipratropium bromide combined with aerosol inhalation in treatment of acute attack of bronchial asthma
HUANG Yanhong
Tanwei Center Hospital of Lingshan Country, Lingshan 535413, China
[Abstract]Objective To investigate the clinical therapeutic effect of the salbutamol and ipratropium bromide combined with aerosol inhalation in treatment of acute attack of bronchial asthma. Methods We Selected 82 cases of bronchial asthma patients with acute onset, who was in our hospital for treatment from December 2011 to December 2013. They were randomly divided into the observation group and the control group, the control group were given routine treatment and salbutamol atomization inhalation treatment. Added the ipratropium bromide aerosol inhalation treatment to the treatment of the control group in observation group. Compared the two groups of the treatment efficacy. Results In the observation group, the significant effective rate was 61.90%, the total effective rate was 95.24%, in the control group, the significant effective rate was 30%, the total effective rate was 77.50%. There was significant difference between the two groups (P<0.05). Conclusion Salbutamol and ipratropium bromide combined atomization inhalation in the treatment of acute attack of bronchial asthma, can significantly increase the therapeutic effect.
[Key words]Salbutamol; Ipratropium bromide; Oxygen atomizing aerosol inhalation; Acute attack of bronchial asthma
支气管哮喘是一种以嗜酸粒细胞、肥大细胞反应为主的气道变应性炎症和气道高反应性为特征的疾病。临床上表现为复发作性伴有哮鸣音的呼气性呼吸困难、胸闷或咳嗽,可自行或治疗后缓解。若长期反复发作可使气道重塑,导致气道增厚与狭窄,临床上属于危急重症,严重者可导致窒息而死亡,严重威胁着患者的健康和生命[1]。本文就我院进行治疗的82 例支气管哮喘急性发作患者进行研究,现报道如下。
1 资料与方法
1.1 一般资料
选取2011年12 月~2013年12 月在本院进行治疗的82例支气管哮喘急性发作患者,经过患者及医院伦理委员会通过,随机分为观察组和对照组,观察组42例,男23例,女19例;年龄18~67岁,平均(42.5±2.1)岁;病程0.4~7.8年,平均(4.90±1.38)年;轻度哮喘7例,中度哮喘25例,重度哮喘10例;对照组40例,男22例,女18例;年龄19~68岁,平均(43.3±2.6)岁;病程0.3~7.5年,平均(5.13±1.42)年。轻度哮喘7例,中度哮喘24例,重度哮喘9例。两组患者在性别组成、年龄、病程、病情程度等方面差异无统计学意义(P>0.05 ),具有可比性。