地尔硫缓解PCI术后心绞痛的临床疗效观察

周琦，史玲，潘云红，王莹

心血管病研究

周琦，史玲，潘云红，王莹

1 资料与方法

1.3 观察指标 (1)心绞痛发作次数，每次发作时间；(2)术前及术后0h、24h、14d、3个月的血压、心率、心肌耗氧量(心率×收缩压)、C反应蛋白(CRP)；(3)3个月后行超声心动图(Acuson公司产Sequoia512型彩色多普勒超声诊断仪)检查左室射血分数(LVEF)及左室短轴缩短率(LVFS)；(4)不良反应。

2 结 果

2.1 心绞痛比较 治疗前2组心绞痛发作次数和持续时间比较无明显差异(P﹥0.05)，与治疗前比较，治疗后2组均显著改善(P<0.05)，且治疗组显著低于对照组(P<0.05)。见表1。

表1 2组患者心绞痛发作次数和持续时间比较

注：与治疗前比较，*P<0.05；与对照组治疗后比较，#P<0.05

2.2 血压、心率、心肌氧耗量、CRP比较 与术前比较，2组血压、心率、心肌氧耗量和CRP水平在术后0h均有所升高(P<0.05)。治疗组收缩压、舒张压、心率、心肌耗氧量和CRP水平在术后24h、14d、3个月明显低于对照组，差异具有统计学意义(P<0.05)。见表2。

2.3 超声心动图指标比较 2组3个月后LVEF与LVFS均较治疗前明显升高，且治疗组较对照组升高更显著，差异具有统计学意义(P<0.05)。见表3。

表3 2组超声心电图指标比较

注：与治疗前比较，*P<0.05；与对照组治疗后比较,#P<0.05

2.4 不良反应 2组治疗后均无明显不良反应如缓慢性心律失常、低血压及心功能恶化，无心力衰竭、休克、过敏、精神神经异常、面部潮红等不良反应。治疗结束时三大常规、血糖、血脂、肝肾功能与治疗前比较均无明显变化。

3 讨 论

表2 2组术前、术后各时间点血压、心率、心肌耗氧量和CRP变化情况

注：与治疗前比较，*P<0.05；与对照组治疗后同时点比较,#P<0.05

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Thetherapeuticeffectofdiltiazemonanginaafterpercutaneouscoronaryintervention

ZHOUQi,SHILing,PANYunhong,WANGYing.

DepartmentofCardiology,WuhanUniversityAffiliatedTianyouHospital,Wuhan431000,China

ObjectiveTo detect the therapeutic effect of diltiazem on angina after percutaneous coronary intervention (PCI).MethodsA total of 180patients after PCI with coronary atherosclerotic heart disease were enrolledin this analysis. All or the patients were randomly dividedinto diltiazem therapy group (102 patients) andnon diltiazem therapy control group (78 patients). We comparedthe frequency andthe duration of angina, the bloodpressure, heart rate, myocardial oxygen consumption, C reactive protein (CRP), left ventricular function (LVEF) andleft ventricular fractional shortening (LVFS) before andafter PCI on 0h, 24h, 14days and3months between the two groups.ResultsThe frequency andthe duration of angina in the therapy group were significantly lower than the control group. The systolic bloodpressure, diastolic bloodpressure, heart rate, myocardial oxygen consumption, andthe CRP in the diltiazem therapy group were significantly lower than the control group at 0h, 24h, 14days and3months after PCI, andthe levels of LVEF andLVFS were significantly higher than the control group (P<0.05). Both two groups hadno adverse reaction.ConclusionDiltiazem can significantly relieve the angina after PCI andimprove the ventricular function, it is worth to use in clinical practice.

Diltiazem; Percutaneous coronary intervention ; Angina pectoris

431000 武汉科技大学附属天佑医院心血管内科

10.3969 / j.issn.1671-6450.2014.01.005

2013-07-03)