Phenotypic appearance of central retinal vein occlusion post AstraZeneca vaccine

The COVID-19 pandemic has brought about the development of novel vaccines at a rapid pace. The AstraZeneca (AZ)COVID-19 adenovirus vector vaccine has been associated with thrombotic complications, the most serious of which includes cerebral venous sinus thrombosis. However, there are no reports in the literature to date regarding ocular manifestations secondary to the AZ COVID-19 vaccine. We present the cases of two otherwise healthy patients with no significant pre-existing co-morbidities presenting with a central retinal vein occlusion (CRVO) within 1wk following AZ COVID-19 vaccination and describe the typical phenotypic appearances.

The study was conducted in accordance with the principles of the Declaration of Helsinki. The informed consent was obtained from the subjects.

A 44-year-old lady presented to eye casualty complaining of two episodes of transient painless blurring of vision in her right eye 5d following her first AZ COVID vaccine. She had no significant past medical or ocular history,was not on any regular medication and was a non-smoker.

On examination Snellen visual acuities were 6/6 right eye and 6/6 left eye. Anterior segments and intraocular pressures were normal bilaterally. Dilated fundal examination of the right eye showed a few scattered flame and blot haemorrhages in all four quadrants (Figure 1). There was no evidence of cystoid macular edema (CME) on optical coherence tomography(OCT) imaging (Figure 2). The left fundus appeared normal.Blood pressure and routine bloods were all essentially normal.A diagnosis of non-ischaemic CRVO in the right eye was made and a 3-month follow up was arranged in the Ophthalmology Clinic. At her 3-month review, the vein occlusion in the right eye had completely resolved and she was discharged.

There appears to be increasing evidence in the literature suggesting a possible association between the AZ COVID-19 vaccine and thrombotic events. Pottegårdreported a standardised morbidity ratio of 1.97 (1.50 to 2.54) and 11 (5.6 to 17.0)excess venous thromboembolic events per 100 000 vaccinations,with an excess of 2.5 (0.9 to 5.2) cerebral venous thrombotic events per 100 000 observed. This possible association has been recognized by European Medicines Agencyand United Kingdom Medicines and Healthcare Products Regulator.

The proposed mechanism of action of AZ COVID-19 related blood clots is an immune response that resembles a rare reaction to the drug heparin, called heparin-induced thrombocytopenia and is referred to as vaccine-induced immune thrombotic thrombocytopenia (VITT). This disorder clinically resembles heparin-induced thrombocytopenia, which is a prothrombotic state caused by platelet-activating antibodies that recognise and bind to complexes of cationic platelet factor 4 (PF4) and anionic heparin. It has been recognised that other triggers apart from heparin can cause this reaction and it is believed that the AZ COVID-19 vaccine does so in this case.It is thought that interactions between the vaccine and platelets or between the vaccine and PF4 may play a role, but the exact pathogenesis still remains unclear.

全国的失能、半失能老年人高达3300万，其中完全失能、需要照顾的老人1100万，占老年总数的6.3%[3]。以现有的居家养老和社区养老条件，还难以实现对这些老人的人性化的关怀和照顾。

The occurrence of CRVO shortly after the mRNA COVID-19 vaccine has been reported previously, however our two cases represent the first documented reports of CRVO in association with the AZ COVID-19 vaccine. We hypothesize that the AZ COVID-19 vaccine predisposes to the development of CRVO with the VITT mechanism of action described in the two New England Journal of Medicine papers. From our two cases,CRVO occurring secondary to AZ COVID-19 vaccination appears to be non-ischaemic and relatively benign in nature,resolving rapidly without complications or requirement for any intervention. Further work in identifying cases may lead to improved understanding of the pathophysiology underlying this phenomenon of thrombosis secondary to AZ COVID-19 vaccination and verification of the VITT mechanism of action which has been proposed.

A 49-year-old lady presented to the eye clinic complaining of blurring of vision in her right eye 4d following inoculation with the AZ COVID-19 vaccine. She had no significant past medical or ocular history, was not on any regular medication and was a non-smoker.

On examination Snellen visual acuities were 6/12 right eye and 6/6 left eye. Anterior segments and intraocular pressures were normal bilaterally. Dilated fundal examination of the right eye showed a few scattered blot haemorrhages in all four quadrants with several cotton wool spots (Figure 3). There was no evidence of CME on OCT imaging (Figure 4). The left fundus appeared normal. Blood pressure and routine bloods were unremarkable. A diagnosis of non-ischaemic CRVO in the right eye was made and a 3-month follow up arranged in the Ophthalmology Clinic. At her 3-month review, Snellen visual acuities were 6/6 bilaterally, the vein occlusion in the right eye had completely resolved and she was discharged.

毫米波雷达测距可分为发射、接收、处理三部分。连续调频毫米波信号通过发射天线发出，电磁波遇到障碍物以后会反射回来，之后被雷达接收天线接收，雷达接收机把接收到的回波信号和参考信号混频，从而得到一个差频信号，把差频信号进行放大、滤波等处理后，通过采样变为数字基带信号，把数字信号进行FFT频谱分析后，就可以提取出目标的距离信息，如图1所示。

Both of our patients were middle aged females, had no significant ocular or systemic risk factors and presented with a mild non-ischaemic CRVO characterised by a mild amount of haemorrhaging with or without cotton wool spots, and without evidence of CME within 1wk of AZ COVID-19 vaccination.Traditional methods of vaccination include attenuated vaccines which utilise microorganisms that have had their virulent properties disabled, or inactivated vaccines which contain microorganisms that have been destroyed and are no longer virulent. The AZ COVID-19 vaccine is a genetic vaccine and is in the sub-group viral vector vaccine. These vaccines use a safe virus to insert pathogen genes in the body to produce specific antigens. The AZ COVID-19 vaccine uses a modified version of a chimpanzee adenovirus, known as ChAdOx1, and contains the gene for the coronavirus spike protein. After inoculation with the AZ COVID-19 vaccine, the patient's immune system subsequently becomes primed to the coronavirus spike protein,enhancing the immune response if the patient encounters the COVID-19 virus in the future.

Honoraria from Bayer,

研究资料和研究结果等数据均采用SPSS23.0软件进行统计分析,计量资料和计数资料分别以±s和%表示,组间比较分别采用t检验和χ2检验,其统计学意义以显著差异P<0.05表示。

应用专用计算软件对发电电动机进行静止变频器(SFC)起动仿真计算，发电电动机励磁电流为1.0(p.u.)，励磁控制方式为恒励磁电流调节方式。起动过程为压水起动，计算中考虑了各种损耗对电机产生的阻力矩，包括水轮机的水导轴承损耗、推力轴承损耗、主轴密封损耗、转轮在空气中旋转的损耗、发电机的上导轴承损耗、下导轴承损耗、推力轴承损耗、通风损耗、铁心损耗、定转子绕组铜耗及杂散损耗等等[6]。另外，静止变频器的容量为18 MW。计算结果，电机的加速时间为210 s左右，即机组从静止状态加速到额定转速的时间(不包括同步并网的时间)见图4。

Allergan, Novartis, Roche and Travel Grants from Bayer,Allergan and Novartis;None;None;Travel Grant from Bayer.