不同疗程布拉氏酵母菌对四联疗法根除Hp的影响

关旭 田桦 卓越

摘要：目的  觀察不同疗程布拉氏酵母菌对四联疗法根除Hp的影响。方法  选择2018年12月～2019年10月佳木斯大学一附院消化内科门诊收治的幽门螺杆菌（Hp）阳性患者160例作为研究对象，随机分为A、B、C、D四组，各40例。A组口服丽珠维三联+雷贝拉唑，B、C和D组在A组基础上分别加用2、4、6周布拉氏酵母菌。比较各组Hp根除率及不良反应发生率。结果  A、B、C、D组Hp根除率分别为50.00%、76.92%、76.32%、81.08%，组间比较，差异有统计学意义（P<0.05）;其中B、C、D组Hp根除率高于A组，差异有统计学意义（P<0.05）;B、C、D组Hp根除率比较，差异无统计学意义（P>0.05）;A、B、C、D组不良反应发生率分别为42.10%、7.50%、5.13%、5.26%，组间比较，差异有统计学意义（P<0.05）;其中B、C、D组不良反应发生率比较，差异无统计学意义（P>0.05）。结论  不同疗程的布拉氏酵母菌联合四联疗法均对Hp的根除有较好的效果，但延长布拉氏酵母菌疗程对Hp根除效果无明显提高作用。

关键词：幽门螺旋杆菌;四联疗法;根除率

中图分类号：R453.2                                 文献标识码：A                                 DOI：10.3969/j.issn.1006-1959.2020.05.046

文章编号：1006-1959（2020）05-0144-02

Abstract：Objective  To observe the effect of different courses of yeast brasiella on the eradication of Hp by quadruple therapy.Methods  From December 2018 to October 2019， 160 Hp-positive patients admitted to the Department of Gastroenterology of the first affiliated hospital of Jiamusi University were selected as the research objects， and they were randomly divided into four groups， A，B，C， and D，with 40 cases each. Group A was orally administered with Lizhuweitriple + rabeprazole， Groups B，C， and D were supplemented with Candida bratellafor 2，4， and 6 weeks on the basis of group A， respectively. Compare the eradication rate of Hp and the incidence of adverse reactions in each group.Results  The root exclusion rates of Hp in A，B，C and D groups were 50.00%，76.92%，76.32% and 81.08% respectively，the difference was statistically significant （P<0.05）; the eradication rate of Hp in groups B，C， and D was higher than that in group A，the difference was statistically significant （P<0.05）; there was no difference in Hp eradication rate in groups B，C， and D（P>0.05）; the incidence of adverse reactions in groups A，B，C， and D were 42.10%，7.50%，5.13%， and 5.26%，the differences between groups were statistically significant （P<0.05）; There was no significant difference in the incidence of adverse reactions between groups B，C， and D （P>0.05）.Conclusion  Different courses of Candida bratella combined with quadruple therapy had good effect on Hp eradication， but prolonged course of Candida bratella had no significant effect on Hp eradication.

Key words：Helicobacter pylori;Quadruple therapy;Eradication rate