米非司酮联合缩宫素在产后出血治疗中的应用及可行性研究

蔡容霞

【摘要】 目的：研究米非司酮聯合缩宫素在产后出血治疗中的应用及可行性。方法：回顾性分析2016年4月-2017年4月笔者所在医院收治的产后出血患者112例的临床资料，按照治疗方法不同分为观察组和对照组，每组56例，将单一采用缩宫素治疗的患者纳入对照组，将采用米非司酮与缩宫素联合治疗的患者设为观察组，比较两组产后出血患者的应用效果、阴道出血量、血红蛋白含量、出血时间、转经时间、转经经期和不良反应发生情况。结果：观察组患者的治疗总有效率为96.43%，明显高于对照组的83.93%，比较差异有统计学意义（P<0.05）；观察组患者血红蛋白含量高于对照组，阴道出血量少于对照组，出血时间、转经时间及转经经期均短于对照组，比较差异均有统计学意义（P<0.05）；观察组患者的不良反应发生率为1.79%，明显低于对照组的12.50%，比较差异有统计学意义（P<0.05）。结论：米非司酮联合缩宫素治疗产后出血具有较高的可行性，能够取得令人满意的治疗效果。

【关键词】 产后出血； 缩宫素； 米非司酮； 可行性

doi：10.14033/j.cnki.cfmr.2018.9.061 文献标识码 B 文章编号 1674-6805（2018）09-0121-03

Application and Feasibility Study of Mifepristone Combined with Oxytocin in the Treatment of Postpartum Hemorrhage/CAI Rongxia.//Chinese and Foreign Medical Research，2018，16（9）：121-123

【Abstract】 Objective：To study the application and feasibility of Mifepristone combined with Oxytocin in the treatment of postpartum hemorrhage.Method：From April 2016 to April 2017，the clinical data of 112 postpartum hemorrhage patients treated in our hospital were retrospectively analyzed.The patients were divided into observation group and control group according to different treatment methods，56 cases in each group.Patients treated with Oxytocin were included into control group，and patients treated with Mifepristone and Oxytocin were included into observation group.The effects of application，vaginal bleeding volume，hemoglobin content，bleeding time，menstruation retrieve time，menstrual period，and adverse reactions were compared between the two groups of postpartum hemorrhage patients.Result：The total effective rate of treatment in the observation group was 96.43%，which was significantly higher than that of the control group（83.93%），the difference was statistically significant（P<0.05）.The hemoglobin content in the observation group was higher than that in the control group，the vaginal bleeding volume was less than that in the control group，the bleeding time，menstruation retrieve time and menstruation period were all shorter than those in the control group，the differences were statistically significant（P<0.05）.The incidence of adverse reactions in the observation group was 1.79%，which was significantly lower than 12.50% in the control group，the difference was statistically significant（P<0.05）.Conclusion：Mifepristone combined with Oxytocin have a high feasibility for the treatment of postpartum hemorrhage and can achieve satisfactory therapeutic effects.

【Key words】 Postpartum hemorrhage； Oxytocin； Mifepristone； Feasibility