喜炎平联合西咪替丁治疗儿童手足口病疗效分析

秦燕玲+寇建军

doi：10.3969/j.issn.1007-614x.2014.14.51

摘 要 目的：探讨喜炎平联合西咪替丁治疗儿童手足口病的临床疗效。方法：2013年1月-2014年1月收治手足口病患儿120例，随机分成观察组和对照组，各60例。对照组给予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韦林加入10～15mg/（kg·日）5%GS静滴；观察组在对照组的基础上加西咪替丁0.2～0.4mg/（kg·日）静滴，两组治疗5天。结果：观察组口腔症状缓解时间（1.74±0.51）天，皮疹好转时间（3.1±1.2）天；对照组口腔症状缓解时间（3.3±1.4）天，皮疹好转时间（4.8±1.6）天，两组比较差异有统计学意义（P<0.05）。观察组显效37例（61.7%），有效21例（35.0%），无效2例，总有效率96.7%；对照组显效28例（46.7%），有效22例（36.7%），无效10例，总有效率83.3%，两组比较差异有统计学意义（P<0.05）。结论：喜炎平联合西咪替丁治疗儿童手足口病症状缓解快，疗效显著，值得推广。

关键词 喜炎平 西咪替丁 利巴韦林 手足口病

Curative effect analysis of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease

Qin Yanling，Kou Jianjun

Pediatrics of The second people's Hospital of Anding District of Dingxi City in Gansu Province，743000

Abstract Objective：To explore the curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease.Methods：120 cases of hand foot and mouth disease were admitted and were randomly divided into the control group and the observation group.The control group were given Xiyanping injection of 0.2 to 0.4ml/kg，1 time/day，ribavirin joined in 10 to 15mg/（kg·day）5% GS for intravenous drip.The observation group added cimetidine 0.2 to 0.4mg/（kg·day）for intravenous drip on the basis of the control group.The treatment time of two groups was 5 days.Results：In the observation group，the remission time of oral symptoms was 1.74±0.51 days，and the turnaround time of rash was 3.1±1.2 days.In the control group，the remission time of oral symptoms was 3.3±1.4 days，and the turnaround time of rash was 4.8±1.6 days.There are statistically significant differences between two groups（P<0.05）.In the observation group，37 cases（61.7%） were markedly effective， 21 cases（35%）were effective，2 cases were ineffective，and the total efficiency was 96.7%.In the control group，28 cases（46.7%） were markedly effective，22 cases（36.7%） were effective，10 cases were ineffective，and the total efficiency was 83.3%.There are statistically significant differences between two groups（P<0.05）.Conclusion：The curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease is significant， and symptom relief is fast，so it is worthy of promotion.

Key words Xiyanping；Cimetidine；Ribavirin；Hand foot and mouth disease

手足口病（HFMD）是婴幼儿常见的肠道引起的一种传染病[1]，多发生于春秋季节[2]，主要表现为小儿手心、足底、口腔、臀部等部位出现皮疹、水疱，多数患者出现发热，若不及时治疗，很容易导致心肌炎、肺水肿等。特别是近年来，呈大面积传播，发病率较高，应该引起有关各部门的注意。在治疗方面，我们采用喜炎平联合西咪替丁进行治疗，疗效显著，现报告如下。

资料与方法

2013年1月-2014年1月收治手足口病患儿120例，男76例，女44例，年龄9个月～7岁，平均5.5岁，主要表现发热、手心、足底、口腔、臀部等部位出现皮疹、水疱，患儿拒食等。血常规检查：白细胞（4.0～10.0）×109/L，中性粒细胞<50%，淋巴细胞>50%。随机分成观察组和对照组，各60例。两组患儿在年龄、性别、临床表现、血常规检查等方面差异无统计学意义，有可比性。

方法：①对照组给予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韦林加入10～15mg/（kg·日）5%GS静滴；②观察组在对照组的基础上加西咪替丁0.2～0.4mg/（kg·日）静滴，两组均治疗5天。

结 果

两组患儿临床症状改善情况比较：观察组口腔症状缓解时间（1.74±0.51）天，皮疹好转时间（3.1±1.2）天；对照组口腔症状缓解时间（3.3±1.4）天，皮疹好转时间（4.8±1.6）天，两组比较有统计学意义（P<0.05），见表1。

两组临床疗效比较： 观察组显效37例（61.7%），有效21例（35.0%），无效2例，总有效率96.7%；对照组显效28例（46.7%），

doi：10.3969/j.issn.1007-614x.2014.14.51

摘 要 目的：探讨喜炎平联合西咪替丁治疗儿童手足口病的临床疗效。方法：2013年1月-2014年1月收治手足口病患儿120例，随机分成观察组和对照组，各60例。对照组给予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韦林加入10～15mg/（kg·日）5%GS静滴；观察组在对照组的基础上加西咪替丁0.2～0.4mg/（kg·日）静滴，两组治疗5天。结果：观察组口腔症状缓解时间（1.74±0.51）天，皮疹好转时间（3.1±1.2）天；对照组口腔症状缓解时间（3.3±1.4）天，皮疹好转时间（4.8±1.6）天，两组比较差异有统计学意义（P<0.05）。观察组显效37例（61.7%），有效21例（35.0%），无效2例，总有效率96.7%；对照组显效28例（46.7%），有效22例（36.7%），无效10例，总有效率83.3%，两组比较差异有统计学意义（P<0.05）。结论：喜炎平联合西咪替丁治疗儿童手足口病症状缓解快，疗效显著，值得推广。

关键词 喜炎平 西咪替丁 利巴韦林 手足口病

Curative effect analysis of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease

Qin Yanling，Kou Jianjun

Pediatrics of The second people's Hospital of Anding District of Dingxi City in Gansu Province，743000

Abstract Objective：To explore the curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease.Methods：120 cases of hand foot and mouth disease were admitted and were randomly divided into the control group and the observation group.The control group were given Xiyanping injection of 0.2 to 0.4ml/kg，1 time/day，ribavirin joined in 10 to 15mg/（kg·day）5% GS for intravenous drip.The observation group added cimetidine 0.2 to 0.4mg/（kg·day）for intravenous drip on the basis of the control group.The treatment time of two groups was 5 days.Results：In the observation group，the remission time of oral symptoms was 1.74±0.51 days，and the turnaround time of rash was 3.1±1.2 days.In the control group，the remission time of oral symptoms was 3.3±1.4 days，and the turnaround time of rash was 4.8±1.6 days.There are statistically significant differences between two groups（P<0.05）.In the observation group，37 cases（61.7%） were markedly effective， 21 cases（35%）were effective，2 cases were ineffective，and the total efficiency was 96.7%.In the control group，28 cases（46.7%） were markedly effective，22 cases（36.7%） were effective，10 cases were ineffective，and the total efficiency was 83.3%.There are statistically significant differences between two groups（P<0.05）.Conclusion：The curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease is significant， and symptom relief is fast，so it is worthy of promotion.

Key words Xiyanping；Cimetidine；Ribavirin；Hand foot and mouth disease

手足口病（HFMD）是婴幼儿常见的肠道引起的一种传染病[1]，多发生于春秋季节[2]，主要表现为小儿手心、足底、口腔、臀部等部位出现皮疹、水疱，多数患者出现发热，若不及时治疗，很容易导致心肌炎、肺水肿等。特别是近年来，呈大面积传播，发病率较高，应该引起有关各部门的注意。在治疗方面，我们采用喜炎平联合西咪替丁进行治疗，疗效显著，现报告如下。

资料与方法

2013年1月-2014年1月收治手足口病患儿120例，男76例，女44例，年龄9个月～7岁，平均5.5岁，主要表现发热、手心、足底、口腔、臀部等部位出现皮疹、水疱，患儿拒食等。血常规检查：白细胞（4.0～10.0）×109/L，中性粒细胞<50%，淋巴细胞>50%。随机分成观察组和对照组，各60例。两组患儿在年龄、性别、临床表现、血常规检查等方面差异无统计学意义，有可比性。

方法：①对照组给予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韦林加入10～15mg/（kg·日）5%GS静滴；②观察组在对照组的基础上加西咪替丁0.2～0.4mg/（kg·日）静滴，两组均治疗5天。

结 果

两组患儿临床症状改善情况比较：观察组口腔症状缓解时间（1.74±0.51）天，皮疹好转时间（3.1±1.2）天；对照组口腔症状缓解时间（3.3±1.4）天，皮疹好转时间（4.8±1.6）天，两组比较有统计学意义（P<0.05），见表1。

两组临床疗效比较： 观察组显效37例（61.7%），有效21例（35.0%），无效2例，总有效率96.7%；对照组显效28例（46.7%），

doi：10.3969/j.issn.1007-614x.2014.14.51

摘 要 目的：探讨喜炎平联合西咪替丁治疗儿童手足口病的临床疗效。方法：2013年1月-2014年1月收治手足口病患儿120例，随机分成观察组和对照组，各60例。对照组给予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韦林加入10～15mg/（kg·日）5%GS静滴；观察组在对照组的基础上加西咪替丁0.2～0.4mg/（kg·日）静滴，两组治疗5天。结果：观察组口腔症状缓解时间（1.74±0.51）天，皮疹好转时间（3.1±1.2）天；对照组口腔症状缓解时间（3.3±1.4）天，皮疹好转时间（4.8±1.6）天，两组比较差异有统计学意义（P<0.05）。观察组显效37例（61.7%），有效21例（35.0%），无效2例，总有效率96.7%；对照组显效28例（46.7%），有效22例（36.7%），无效10例，总有效率83.3%，两组比较差异有统计学意义（P<0.05）。结论：喜炎平联合西咪替丁治疗儿童手足口病症状缓解快，疗效显著，值得推广。

关键词 喜炎平 西咪替丁 利巴韦林 手足口病

Curative effect analysis of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease

Qin Yanling，Kou Jianjun

Pediatrics of The second people's Hospital of Anding District of Dingxi City in Gansu Province，743000

Abstract Objective：To explore the curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease.Methods：120 cases of hand foot and mouth disease were admitted and were randomly divided into the control group and the observation group.The control group were given Xiyanping injection of 0.2 to 0.4ml/kg，1 time/day，ribavirin joined in 10 to 15mg/（kg·day）5% GS for intravenous drip.The observation group added cimetidine 0.2 to 0.4mg/（kg·day）for intravenous drip on the basis of the control group.The treatment time of two groups was 5 days.Results：In the observation group，the remission time of oral symptoms was 1.74±0.51 days，and the turnaround time of rash was 3.1±1.2 days.In the control group，the remission time of oral symptoms was 3.3±1.4 days，and the turnaround time of rash was 4.8±1.6 days.There are statistically significant differences between two groups（P<0.05）.In the observation group，37 cases（61.7%） were markedly effective， 21 cases（35%）were effective，2 cases were ineffective，and the total efficiency was 96.7%.In the control group，28 cases（46.7%） were markedly effective，22 cases（36.7%） were effective，10 cases were ineffective，and the total efficiency was 83.3%.There are statistically significant differences between two groups（P<0.05）.Conclusion：The curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease is significant， and symptom relief is fast，so it is worthy of promotion.

Key words Xiyanping；Cimetidine；Ribavirin；Hand foot and mouth disease

手足口病（HFMD）是婴幼儿常见的肠道引起的一种传染病[1]，多发生于春秋季节[2]，主要表现为小儿手心、足底、口腔、臀部等部位出现皮疹、水疱，多数患者出现发热，若不及时治疗，很容易导致心肌炎、肺水肿等。特别是近年来，呈大面积传播，发病率较高，应该引起有关各部门的注意。在治疗方面，我们采用喜炎平联合西咪替丁进行治疗，疗效显著，现报告如下。

资料与方法

2013年1月-2014年1月收治手足口病患儿120例，男76例，女44例，年龄9个月～7岁，平均5.5岁，主要表现发热、手心、足底、口腔、臀部等部位出现皮疹、水疱，患儿拒食等。血常规检查：白细胞（4.0～10.0）×109/L，中性粒细胞<50%，淋巴细胞>50%。随机分成观察组和对照组，各60例。两组患儿在年龄、性别、临床表现、血常规检查等方面差异无统计学意义，有可比性。

方法：①对照组给予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韦林加入10～15mg/（kg·日）5%GS静滴；②观察组在对照组的基础上加西咪替丁0.2～0.4mg/（kg·日）静滴，两组均治疗5天。

结 果

两组患儿临床症状改善情况比较：观察组口腔症状缓解时间（1.74±0.51）天，皮疹好转时间（3.1±1.2）天；对照组口腔症状缓解时间（3.3±1.4）天，皮疹好转时间（4.8±1.6）天，两组比较有统计学意义（P<0.05），见表1。

两组临床疗效比较： 观察组显效37例（61.7%），有效21例（35.0%），无效2例，总有效率96.7%；对照组显效28例（46.7%），