PLENARY LECTURES

1. Pharmacological study on traditional Chinese medicine and natural product in China
2. GPCRomics:tissue and cellular GPCR expression identifies new therapeutic targets

INVITED LECTURES

1. Direction of new drug research:soft regulation of inflammatory immune responses
2. Targeting Gprotein-coupled receptors for the treatment of autoimmune diseases
3. Arrestin mediated GPCR biased signaling and its application in new drug discovery
4. Identification of a novel target for cancer and anti-fibrotic therapy
5. Rational design of GRK2 inhibitors for the treatment of heart failure
6. Drugs and natural products:from plants and livestock to human therapeutics
7. Berberine is a new mechanism drug against energy metabolic disorder
8. A systematic approach to select and evaluate natural products as precipitants of pharmacokinetic natural product-drug interactions
9. Collateral disease research and translational medicine
10. New approaches for identifying biologically active components of botanical natural products
11. Reverse pharmacokinetics guided target identification and mechanistic understanding of Chinese medicines

T1 MOLECULAR PHARMACOLOGY AND DRUG DISCOVERY

1. Identification and optimization of a potent and highly selective D3 dopamine receptor agonist
2. Abuse-related effects of synthetic cathinones:importance of DAT/SERT relationships
3. Cell-type specific examination of central amygdala dopamine receptor 2 expressing neurons as a translational target for pharmacological enhancement of extinction
4. Diazepam reduces synaptic GABA type areceptor availability via multiple trafficking mechanisms
5. A novel GPCR mediates pancreatic cancer associated fibroblast-cancer cell interaction
6. Targeting androgen receptor and trail:a novel treatment paradigm for breast cancer
7. Studies on the mechanism of SIRT1/AMPK signaling pathway between hepatocytes and hepatic stellate cells
8. Research progress of TREM2 in Alzheimer disease
9. TRPA1 channel mediates organophosphate-induced delayed neuropathy
10. Cytoplasmic translocation of Cx32 mediates cisplatin resistance in ovarian cancer cells
11. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo
12. Gecko crude peptides inhibit migration and lymphangiogenesis by down regulating the expression of VEGF-C in human hepatocellular carcinoma cells and human lymphatic endothelial cells
13. Regulatory effects of GRK2 on GPCRs and possible use as a drug target
14. Selective targeting p53WTlung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA
15. Inhibition of cervical cancer cell proliferation and cervical tumorigenicity caused by farnesoid X receptor activation or over-expression is related to CDKN2A-p14ARF-MDM2-p53 pathway
16. Inhibition of miR-873 provides therapeutic benefit in lipopolysaccharide-induced Parkinson disease animal model
17. PD-1/PD-L1 checkpoint blockade in immune-antitumortherapy:advances and perspectives
18. Regulation of nitric oxide donor JS-K on tumor energy metabolism in H22 tumor-bearing mice
19. DL0410,a candidate for anti-Alzheimer disease with multiple targets in multiple pathways
20. Saikosaponin-b regulates the proliferation and apoptosis of HepG2 cells by targeting the MACC1/c-Met/Akt signaling pathway
21. Insulin-like growth factor-binding protein-3 inhibits IGF-1-induced proliferation of human hepatocellular carcinoma cells
22. Restoration of E-cadherin by compound 8J protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death
23. Protective role of brain CYP2J in diverse Parkinson disease animal models
24. Combination of carboxyamidotriazole and 1-Methyl-L-tryptophan has synergistic inhibtory effects on programmed death 1 expression
25. A novel anti-inflammatory and immunomodulatory drug CP-25 alleviated collagen induced arthritis by down-regulating BAFF-NF-κ B signaling pathway
26. Development of an XBP1 agonist,HLJ2,as a potential therapeutic agent for ulcerative colitis
27. Gprotein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis
28. Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells
29. Drug repurposing of histone deacetylase inhibitors that alleviate neutrophilic inflammation in acute lung injury and idiopathic pulmonary fibrosis viainhibiting leukotriene a4 hydrolase and blocking LTB4 biosynthesis
30. Effects of methionine enkephalin on immune enhancement by reducing myeloid derived suppressor cells and reprogramming liver metabolism in colon cancer mice
31. MicroRNA-10a promotes granulosa cells tumor development
32. Estrogen weakens muscle endurance via estrogen receptor-MAPK mediated orosomucoid suppression
33. Cellular and molecular perspectives of macrophage in rheumatoid arthritis
34. PID1,a new tumor-promoting gene in insulin resistance mediated acceleration of hepatocellular carcinoma development and progression
35. Effects of immunoglobulin D on expression of IgD receptor and protein tyrosine kinase signaling in human CD4+T cells
36. Improved anti-tumor efficacy and pharmacokinetics of bufalin via PEGylated liposomes
37. Involvement of PPARs in the regulation of brain CYP2D by growth hormone
38. Discovery of a small-molecule bromodomain-containing protein 4 inhibitor that induces AMP-activated protein kinase-modulated autophagy-associated cell death in breast cancer
39. A small-molecule activator of ULK1 that induces cytoprotective autophagy for Parkinson disease treatment
40. Functionally diverse ligands modulate different activation states of the formyl peptide receptor 2,a Gprotein-coupled receptor
41. CP-25 inhibits the functions of activated human B cells through regulating BAFF-TRAF2-NF-κ B and TNF-alpha-TRAF2-NF-κ B signaling
42. SOD mimicAEOL-10150 improve lifespan and delay brain aging via inhibition of senescence-associated secretory phenotype in SAMR1 strain
43. Protective action of aspirin and its against endothelial Nlrp3 inflammasome activation in response to LPS stimuli

T2 TRADITIONAL CHINESE MEDICINES AND NATURAL PRODUCTS

1. Bile salt derivatives with novel skeleton from sea lamprey function as putative pheromone
2. Progress in preventive effects of cordyceps sinensis on ischemic brain
3. Ginsenoside metabolite compound K alleviate collegen-induced arthritis through impairing dendritic cells function
4. Effects of LW-AFC,a new formula derived from Liuwei Dihuang decoction,on intestinal microbiome in senescence-accelerated mouse prone 8 strain,a mouse model of Alzheimer disease
5. Xiaochaihutang attenuates liver fibrosis in rats through activation of Nrf2 pathway
6. Protective effects of imperatorin against cerebral ischemia/reperfusion-induced oxidative stress through Nrf2 signaling pathway in rats
7. LW-AFC and its active components ameliorate corticosterone-induced long-term potentiation impairment in mice
8. Effect of Shenfu injection on microcirculation effect index in early-and middle-stage of cardiogenic shock rats
9. Research progress of tonic Chinese medicine on the immune system
10. Protective effect and its mechanism of codonopsis pilosula polysaccharide on memory consolidation disorder induced by cycloheximide in mice
11. Lychee seed saponins improve cognitive function and ameliorate hippocampal neuronal injury in Alzheimer disease rat model induced by Aβ 25-35through AKT/GSK3β pathway
12. Protective estrogen-like properties and mechanism of quercetin in rat cerebral cortex neurons
13. Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/Glo-1 mediated by phosphorylation regulation
14. Herb-herb interaction in traditional Chinese medicine：a review of pharmacokinetics-based interaction in Herb-Pairs
15. Mechanistic study on the pharmacokinetic process of salidroside in hypoxic rats
16. Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer
17. miRNA-124 in immune system and immune disorders
18. Nicotine protects against ulcerative colitis through regulating microRNA-124 and STAT3
19. Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model
20. Neuroprotective effect of quercetin on beta-amyloid-induced PC12 cells injury and potential related mechanism
21. LW-AFC,a new formula derived from Liuwei Dihuang decoction,ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune abnormalities in PrP-hAβ PPswe/PS1ΔE9transgenic mice
22. Comprehensive regulation of traditional Chinese medicine on proliferation and differentiation of neural stem cells
23. Beneficial effect of berberine on atherosclerosis based on attenuating vascular inflammation and calcification
24. Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α -Synuclein and Huntingtin in PC-12 cells
25. Dimethyl sulfide,a metabolite of the marine microorganism,protects SH-SY5Y cells against 6-hydroxydopamine and MPP+-induced apoptosis
26. Review for treatment and signaling pathway regulation of kidney-tonifying traditional Chinese medicine on osteoporosis
27. Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomeraseⅠ and topoisomeraseⅡ
28. Ganoderma triterpenes slow cyst growth in polycystic kidney disease
29. Inhibitory effect of baicalein on mice tremor induced by oxotremorine and mechanisms
30. Hepato-protective effect of thymoquinone against acetaminophen induced liver injury is associated with regulation of JNK and AMPK signaling pathway
31. 20C，a new bibenzyl compound,plays a significant role in rotenone-induced oxidative insult
32. Application of an ultra performance liquid chromatography-tandem mass spectrometry method to the pharmacokinetics study of paeoniflorin-6′-O-benzene sulfonate and its active paeoniflorin metabolite in rat plasma
33. Wudang cherry ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice
34. Enhanced anti-cancer effect of gambogic acid by gold nanorod-based delivery
35. Salvianolic acid A ameliorates AGEs-induced glomerular endothelial dysfunction and protects against diabetic nephropathy
36. Advances in research on chemical constituents,pharmacological actions and processing of atractylodes macrocephala
37. Neuroprotective effect of LSS on Aβ 1-42-induced BV-2 microglial cells through the inhibition of neuroinflammation
38. Effect of Guizhi Fuling capsule and its extracts on human breast cancer cells proliferation

T3 OTHERS

1. Effect of differential rearing environments on nicotine-stimulated locomotor activity and nicotinic acetylcholine receptor subtypes
2. Cell-based therapy for management of osteoarthritis
3. Neurotransmitter systems in mouse airways
4. Pharmacological characterizationof synthetic cannabinoid MAM-2201:radioligand binding and abuse-related effects
5. Function of IgD on lymphocyte activation and effect of hIgD-Fc-Ig fusion protein on human PBMC proliferation
6. MLKL forms cation channels
7. Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture
8. Glucuronidation is the dominating in-vivo metabolism pathway of herbacetin:elucidation of herbacetin pharmacokinetics after intravenous and oral administration in rats
9. Topically applied hypericin exhibits skin penetrability on nude mice
10. Biphasic modulation of chemerin peptide-induced calcium flux and ERK phosphorylation by amyloid beta peptide
11. Pharmacokinetics and pharmacodynamics of cisatracurium in children undergoing cleft lip or cleft palate repair surgery
12. Assembly of a highly stable luminescent Zn5 cluster and application to bio-imaging
13. Analysis of the key networks,metabolic pathways,and regulation substances of hypoxia based on the omics and zebrafish model
14. Gap junctions enhance the antiproliferative effect by transfer of microRNAs in glioma cells
15. Reassessment subacute MPTP-treated mice model of Parkinson disease
16. Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinaseⅡ
17. Specific role of synovial macrophages in rheumatoid arthritis
18. Connexin 40-formed GJIC increases the phototoxicity of photodynamic therapy through ROS-and calcium-mediated pathways
19. Inhibitory effect of compound NS5806 on cardiac transient outward potassium channel dependents on interaction between auxiliary subunits
20. Involvement of cysteinyl leukotriene signaling in microglial morphological changes and CASP1 expression in vitro
21. Meta-analysis of serum copper and heart failure

1. Protective role of FoxO transcription factors against oxidative stress-induced chondrocyte dysfunction:a new therapeutic target for osteoarthritis