Meta-analysis of serum copper and heart failure

An-qi ZHANG,Li-la ZHU,Xi-yue ZHANG

(Affiliated Clinical Medicine Department of Tianjin Medical University,Tianjin 300070,China）

T3-20

Meta-analysis of serum copper and heart failure

An-qi ZHANG,Li-la ZHU,Xi-yue ZHANG

(Affiliated Clinical Medicine Department of Tianjin Medical University,Tianjin 300070,China）

OBJECTIVEThe purpose of this study is to clarify the association between Cu levels and heart failure（HF）using a meta-analysis approach.METHODSWe searched articles in the PubMed,EMbase,CNKI,Wanfang,VIP and CBM Database published as of August 2016.The case control study on the relationship between serum copper levels and HF were collected and read and extracted by two independent researchers.A Meta analysis was conducted using Stata 12.0 software.RESULTSA total of twenty-one eligible articles,including 893 HF and 654 control subjects,were enrolled.The Meta analysis showed that serum copper levels in HF were higher than control group〔SMD=0.881,95%CI:(0.487,1.264),Z=4.5,P＜0.001〕.The sensitivity analysis indicated that the results were reliable.Begg′s tests did not find the existence of publication bias.CONCLUSIONThis metaanalysis indicates that there is a significant association between high Cu serum level and HF.

heart failure;serum cu;meta analysis

An-qi ZHANG,Tel:13920066582,E-mail：zanljf@163.com