Distinct molecular profiles of skull bone marrow in health and neurological disorders
2023-03-03ZeynepIlginKolabasetal
Zeynep Ilgin Kolabas,et al.
The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype.Ⅰn humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skullmeninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET)imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.
杂志排行
四川生理科学杂志的其它文章
- 罗哌卡因复合舒芬太尼硬膜外麻醉在无痛分娩中的麻醉、镇痛作用分析
- “动物生理学”课程融入思政教育的实践与思考#
- The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9
- Outcomes of repeat transcatheter aortic valve replacement with balloon-expandable valves: a registry study
- PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development
- Will climate change amplify epidemics and give rise to pandemics