《中国肿瘤生物治疗杂志》常用英文缩略词表

根据科技名词使用规则，本专业及相邻专业领域已被公认公知的缩略词可以不加注释直接使用，非公认公知的缩略词首次出现时应按规范格式写出全称。为方便作者和读者撰写和阅读论文，本刊编辑部整理了一批肿瘤生物治疗专业中公认公知的常用英文缩略词，并注明其英文全称和中文名称。作者撰写论文时，可直接使用这些缩略词,无需写出英文全称。

5-A z a-C d R 5-a z a-2'-d e o x y c y t y d i n e 5-氮[杂]-2'-脱氧胞苷5-F U 5-f l u o r o u r a c i l 5-氟尿嘧啶A A V a d e n o-a s s o c i a t e d v i r u s 腺相关病毒A D C C a n t i b o d y d e p e n d e n t c e l l m e d i a t e d c y t o t o x i c i t y 抗体依赖细胞介导的细胞毒作用A D R a d v e r s e d r u g r e a c t i o n 药物不良反应A F P a l p h a-f e t o p r o t e i n 甲胎蛋白A I D S a c q u i r e d i m m u n o d e f i c i e n c y s y n d r o m e 获得性免疫缺陷综合征(艾滋病)A L L a c u t e l y m p h o i d l e u k e m i a 急性淋巴细胞白血病A M L a c u t e m y e l o b l a s t i c l e u k e m i a 急性粒细胞白血病A P C a n t i g e n p r e s e n t i n g c e l l 抗原提呈细胞A T C C A m e r i c a n T y p e C u l t u r e C o l l e c t i o n 美国模式培养物保藏所B c l-2 B c e l l l y m p h o m a-2 B细胞淋巴瘤2 b F G F b a s i c f i b r o b l a s t g r o w t h f a c t o r 碱性成纤维细胞生长因子C A R c h i m e r i c a n t i g e n r e c e p t o r 嵌合抗原受体C A R-T c h i m e r i c a n t i g e n r e c e p t o r g e n e-m o d i f i e d T l y m p h o c y t e 嵌合抗原受体基因修饰T淋巴细胞C D c l a s t e r o f d i f f e r e n t i a t i o n 白细胞分化抗原群C D K c y c l i n-d e p e n d e n t k i n a s e 周期蛋白依赖性激酶C E A c a r c i n o e m b r y o n i e a n t i g e n 癌胚抗原C F U c o l o n y-f o r m i n g u n i t 集落形成单位c i r c R N A c i r c u l a r R N A 环状R N A C I K c y t o k i n e i n d u c e d k i l l e r c e l l 细胞因子诱导的杀伤细胞C M L c h r o n i c m y e l o i d l e u k e m i a 慢性粒细胞白血病C R c o m p l e t e r e s p o n s e 完全缓解C R I S P R-C a s c l u s t e r e d r e g u l a r l y i n t e r s p a c e d s h o r t p a l i n d r o m i c r e p e a t-c l u s t e r e d 成簇规律间隔短回文重复系统r e g u l a r l y i n t e r s p a c e d s h o r t p a l i n d r o m i c r e p e a t s a s s o c i a t e d s y s t e m C S C c a n c e r s t e m c e l l肿瘤干细胞C S F c o l o n y-s t i m u l a t i n g f a c t o r 集落刺激因子C T C c i r c u l a t i n g t u m o r c e l l 循环肿瘤细胞C T L c y t o t o x i c T l y m p h o c y t e 细胞毒性T淋巴细胞C T L A-4 c y t o t o x i c T l y m p h o c y t e a n t i g e n-4 细胞毒性T淋巴细胞抗原-4 C T X c y c l o p h o s p h a m i d e 环磷酰胺C X C R 4 C-X-C m o t i f c h e m o k i n e r e c e p t o r 4 C X C类趋化因子受体4 D C d e n d r i t i c c e l l 树突状细胞D C R d i s e a s e c o n t r o l r a t e 疾病控制率D F S d i s e a s e f r e e s u r v i v a l 无病生存期D R d e a t h r e c e p t o r 死亡受体D R F S d i s t a n t r e c u r r e n c e f r e e s u r v i v a l 无远处复发生存D N M T D N A m e t h y l t r a n s f e r a s e D N A甲基转移酶E B(E t B r) e t h i d i u m b r o m i d e 溴化乙锭E B V E p s t e i n-B a r r v i r u s E B病毒E C M e x t r a c e l l u l a r m a t r i x 细胞外基质E G F/-R e p i d e r m a l g r o w t h f a c t o r/-r e c e p t o r 表皮生长因子/-受体E L I S A e n z y m e-l i n k e d i m m u n o s o r b e n t a s s a y 酶联免疫吸附测定E M T e p i t h e l i a l-m e s e n c h y m a l t r a n s i t i o n 上皮间质转化

ER estrogen receptor 雌激素受体ERK extracellular signal-regulated kinase/extra- 细胞外信号调节激酶/细胞外蛋白cellular regulated protein kinase 调节激酶ESC embryonic stem cell 胚胎干细胞ESCC esophageal squamous cell carcinoma 食管鳞状细胞癌FACS fluorescence activated cell sorting 荧光激活细胞分选术FADD Fas-associated with death protein domain Fas相关死亡域蛋白FAK focal adhesion kinase 黏着斑激酶FAP focal adhesion plaque 黏着斑FCM flow cytometry/flow cytometer 流式细胞术/流式细胞仪FDA Food and DrugAministration 食品药品管理局(美国)FGF/-R fibroblast growth factor/-receptor 成纤维细胞生长因子/-受体FISH fluorescence in situ hybridization 荧光原位杂交FITC fluorescein isothiocyanate 异硫氰酸荧光素FLI1 Friend leukemia virus integration 1 Friend白血病病毒插入位点1 GFP green fluorescent protein 绿色荧光蛋白G-CSF granulocyte colony-stimulating factor 粒细胞集落刺激因子GM-CSF granulocyte-macrophage colony-stimulating factor 粒细胞-巨噬细胞集落刺激因子GVHD graft versus host disease 移植物抗宿主病HCC hepatocellular carcinoma 肝细胞癌HDAC histone deacetylase 组蛋白去乙酰化酶H-E stain hematoxylin and eosin staining 苏木精-伊红染色HER2 human epidermal growth factor receptor 2 人表皮生长因子受体2 HGF hematopoietic growth factor 造血生长因子HGF/-R hepatocyte growth factor/-receptor 肝细胞生长因子/-受体HIF hypoxia-inducible factor 缺氧诱导因子HIV human immunodeficiency virus 人类免疫缺陷病毒HL Hodgkin lymphoma 霍奇金淋巴瘤HLA human leukocyte antigen 人白细胞抗原HMGB1 high mobility group box 1 高迁移率族蛋白1 HPLC high performance liquid chromatography 高效液相层析色谱HPV human papilloma virus 人乳头状瘤病毒HRP horseradish peroxidase 辣根过氧化物酶HSC hematopoietic stem cell 造血干细胞HSP heat shock protein 热激蛋白HSV herpes simplex virus 单纯疱疹病毒HUVEC human umbilican vein endothelial cell 人脐静脉内皮细胞ICAM intercellular adhesion molecule 细胞间黏附分子IFN interferon 干扰素IGF/-R insulin-like growth factor/-receptor 胰岛素样生长因子/-受体IHC immunohistochemistry 免疫组织化学IL interleukin 白细胞介素IMiD immunomodulatory drug 免疫调节药物ISH in situ hybridization 原位杂交JNK c-Jun N-terminal kinase c-Jun氨基末端激酶KAR killer activation receptor 杀伤细胞激活受体KEGG Kyoto Encyclopedia of Genes and Genomes 京都基因与基因组百科全书KIR killer inhibitory receptor 杀伤细胞抑制受体KPS Karnofsky performance status 卡氏（Karnofsky）功能状态评分LAG3 lymphocyte-activation gene 3 淋巴细胞活化基因3 LAK lymphokine-activated killer cell 淋巴因子激活的杀伤细胞

LDH lactate dehydrogenase 乳酸脱氢酶lncRNA long non-coding RNA 长链非编码RNA LR local recurrence 局部复发LPS lipopolysaccharide 脂多糖LRP lung resistance-related protein 肺耐药相关蛋白LSCM laser scanning confocal microscope 激光扫描共聚焦显微镜LTR long terminal repeat 长末端重复序列MAGE melanoma antigen 黑色素瘤抗原MAPK mitogen-activated protein kinase 促分裂原活化蛋白激酶MDR multidurg resistance 多药耐药MDSC myeloid-derived suppressor cell 髓源性抑制细胞MHC major histocompatibility complex 主要组织相容性复合体miRNA microRNA 微小RNA MLR mixed lymphocyte reaction 混合淋巴细胞反应MM multiple myeloma 多发性骨髓瘤MMP matrix metalloproteinase 基质金属蛋白酶MSC mesenchymal stem cell 间质干细胞MSI microsatellite instability 微卫星不稳定性MST median survival time 中位生存时间MTD maximum tolerate dose 最大耐受剂量mtDNA mitochondrial DNA 线粒体DNA MTKI multi-target tyrosine kinase inhibitor 多靶点酪氨酸激酶抑制剂mTOR mammalian target of rapamycin 哺乳动物雷帕霉素靶蛋白MTT thiazolyl blue 噻唑蓝MVD microvessel density 微血管密度Mφ cell macrophage cell 巨噬细胞NF-κB nuclear factor-κB 核因子κB NGF/-R nerve growth factor/-receptor 神经生长因子/-受体NHL non-Hodgkin lymphoma 非霍奇金淋巴瘤NKG2A natural killer group 2 memberA 自然杀伤细胞2族成员A NKT cell natural killer T cell 自然杀伤T细胞NK cell natural killer cell 自然杀伤细胞NOS nitric oxide synthase 一氧化氮合酶NSCLC non-small cell lung cancer 非小细胞肺癌ORR objective response rate,overall response rate 客观有效率,总有效率OS overall survival 总生存期PAGE polyacrylamide gel eletrophoresis 聚丙烯酰胺凝胶电泳PBMC peripheral blood mononuclear cell 外周血单个核细胞PCR polymerase chain reaction 聚合酶链式反应PD progressive disease 疾病进展PD-1 programmed death-1 程序性死亡受体-1 PD-L1 programmed death ligand-1 程序性死亡受体配体-1 PDGF/-R platelet derived growth factor/-receptor 血小板衍生生长因子/受体PFS progression free survival 无进展生存期P-gp P-glycoprotein(permeability-glycoprotein) P-糖蛋白（渗透性糖蛋白）PI propidium iodide 碘化丙啶PI3K phosphatidylinositol 3-hydroxy kinase 磷脂酰肌醇-3-羟基激酶PIP3 phosphtidylinositol(3,4,5)-trisphosphate 磷脂酰肌醇(3,4,5)三磷酸PKA proteinkinaseA 蛋白激酶A PKC proteinkinase C 蛋白激酶C PLC phospholipase C 磷酯酶C PR partial remission 部分缓解PRR pattern recognition receptor 模式识别受体PSA prostate specific antigen 前列腺特异抗原

PSMA prostate specific membrane antigen 前列腺特异性膜抗原PTEN phosphatase and tensin homology deleted on chromosome ten 10号染色体缺失的磷酸酶和张力蛋白同源物PTK protein tyrosine kinase 蛋白酪氨酸激酶QOL quality of life 生活质量qPCR Real-time quantitative PCR 实时(荧光)定量PCR RCC renal cell carcinoma 肾细胞癌RCT randomized controlled trial 随机对照试验RFS relapse free survival 无复发生存ROC receiver operator characteristic curve 受试者工作特征曲线RR response rate 反应(有效)率RT-PCR reverse transcription-PCR 逆转录聚合酶链式反应RT-qPCR reverse transcription Real-time quantitative PCR 实时(荧光)定量逆转录聚合酶链式反应SA streptavidin 链霉亲和素ScFv single chain Fv 单链抗体SCID severe combined immune deficient disease 重症联合免疫缺陷病SD stable disease 疾病稳定SDS sodium dodecyl sulfate 十二烷基硫酸钠SNP single nucleotide polymorphism 单核苷酸多态性STAT signal transducer and activator of transcription 信号转导及转录激活因子TAA tumor-associated antigen 肿瘤相关抗原TAK tumor antigen-activated killer cell 肿瘤抗原激活杀伤细胞TAF tumor angiogenesis factor 肿瘤血管生成因子TAIT tumor adoptive immume therapy 肿瘤过继免疫治疗TAM tumor-associated macrophage 肿瘤相关巨噬细胞TCR T cell receptor T淋巴细胞受体TCR-T T cell receptor gene-modified T lymphocyte T淋巴细胞受体基因修饰T淋巴细胞TGF transforming growth factor 转化生长因子Th helper T cell 辅助性T淋巴细胞Treg cell regulatory T cell 调节性T淋巴细胞Ts suppressor T cell 抑制性T淋巴细胞TIL tumor-infiltrating lymphocyte 肿瘤浸润淋巴细胞TIM-3 T cell immunoglobulin and mucin-containing protein-3 T细胞免疫球蛋白黏蛋白分子3 TKI tyroline kinase inhibitor 酪氨酸激酶抑制剂TLR Toll-like receptor Toll样受体TNF tumor necrosis factor 肿瘤坏死因子TNM Tumor Node Metastasis 国际肿瘤分期标准[根据肿瘤(T)、淋巴结(N)及转移(M)情况的癌症分类法]TPA tumor polypeptide antigen 肿瘤多肽抗原TRAIL TNF-related apoptosis-inducing ligand 肿瘤坏死因子相关凋亡诱导配体TSA tumor-specific antigen 肿瘤特异性抗原TSTA tumor specific transplantation antigen 肿瘤特异性移植抗原TTF time to treatment failure 治疗失败时间TTP tumor to progression 肿瘤进展UTR untranslated region 非翻译区VEGF/-R vascular endothelial growth factor/-receptor 血管内皮生细胞长因子/-受体VP16 etoposide 依托泊苷WB Western blotting Western印迹,蛋白质印迹法WHO World Health Organization 世界卫生组织ZNF zinc finger protein 锌指蛋白