ESAT-6在结核性腹膜炎中的检测及其诊断应用

饶希 赖玲玲 杨丽霞

[摘要] 目的 研究ESAT-6在结核性腹膜炎中的检测及其诊断应用价值。 方法 选择2017年1月至2020年1月我院接诊的62例疑似结核性腹膜炎患者作为本研究对象。按照最终的诊断结果分为结核性腹膜炎组50例和肿瘤性腹水组12例。比较两组患者外周血中ESAT-6的阳性检出率、腹腔积液中ESAT-6的阳性检出率;对ESAT-6在结核性腹膜炎检测中的敏感度、特异度、阳性预测率、阴性预测率、阳性似然比、阴性似然比、约登指数进行比较。 结果 结核性腹膜炎组患者外周血中ESAT-6的阳性率明显高于肿瘤性腹水组，差异有统计学意义（P<0.05）。结核性腹膜炎组患者腹腔积液中ESAT-6的阳性率明显高于肿瘤性腹水组，差异有统计学意义（P<0.05）。外周血T淋巴细胞中ESAT-6的敏感度、特异度、阳性预测率、阴性预测率、阳性似然比、阴性似然比、约登指数与腹腔积液T淋巴细胞中ESAT-6比较，差异无统计学意义（P>0.05）。 结论 ESAT-6在结核性腹膜炎的检测中有较高的应用价值，可以作为评估患者的重要的指标。

[关键词] 结核性腹膜炎;抗原靶蛋白6;诊断价值;阳性率;敏感度;特异度

[中图分类號] R526          [文献标识码] B          [文章编号] 1673-9701（2021）24-0149-03

Detection and diagnostic application of ESAT-6 in tuberculous peritonitis

RAO Xi   LAI Lingling   YANG Lixia

Department of Infectious Disease， the First Affiliated Hospital of Nanchang University， Nanchang   330006， China

[Abstract] Objective To study the detection and diagnostic application value of ESAT-6 in tuberculous peritonitis. Methods A total of 62 patients with suspected tuberculous peritonitis who were admitted to our hospital from January 2017 to January 2020 were selected as the subjects of this study. According to the final diagnosis results， they were divided into the tuberculous peritonitis group（n=50） and the neoplastic ascites group（n=12）. The positive detection rates of ESAT-6 in peripheral blood and intraperitoneal effusion were compared between the two groups. The sensitivity， specificity， positive prediction rates， negative prediction rates， positive likelihood ratios，negative likelihood ratios and Youden indexes of ESAT-6 in tuberculous peritonitis were compared. Results The positive rate of ESAT-6 in peripheral blood of the tuberculous peritonitis group was significantly higher than that of the neoplastic ascites group， and the difference was statistically significant（P<0.05）. The positive rate of ESAT-6 in peritoneal effusion in the tuberculous peritonitis group was significantly higher than that in the neoplastic ascites group， and the difference was statistically significant（P<0.05）. No statistically significant differences were observed in the sensitivity， specificity， positive prediction rates， negative prediction rates， positive likelihood ratios，negative likelihood ratios and Youden indexes of ESAT-6 between the peripheral blood T lymphocytes and the peritoneal effusion T lymphocytes（P>0.05）. Conclusion ESAT-6 has a high application value in the detection of tuberculous peritonitis， and can be used as an important index to evaluate patients.