静脉滴注蔗糖铁治疗缺铁性贫血的有效性与安全性分析

崔文婷　　胡苏　　靳俊达　　黄燕　　欧阳鹏　　冯波

[关键字] 静脉滴注;口服铁剂;蔗糖铁;缺铁性贫血;有效性;安全性

[中图分类号] R556          [文献标识码] B          [文章编号] 1673-9701（2021）20-0097-04

The effectiveness and safety of intravenous drip of iron sucrose in the treatment of iron deficiency anemia

CUI Wenting   HU Su   JIN Junda   HUANG Yan   OUYANG Peng   FENG Bo

Department of Hematology，Jiujiang NO.1 People's Hospital in Jiangxi Province，Jiujiang   332000，China

[Abstract] Objective To investigate the effectiveness and safety of intravenous drip of iron sucrose in patients with iron deficiency anemia. Methods Eighty patients with iron deficiency anemia who were treated in our hospital from June 2018 to February 2020 were randomly divided into the control group and the observation group，with 40 cases in each group.The control group was given oral iron supplements，and the observation group was given intravenous drip of iron sucrose.Hemoglobin （Hb），serum ferritin （SF）， treatment time，the total incidence of adverse reactions after treatment，and total effective rate of treatment before and after treatment were recorded in detail and compared. Results There was no significant difference in Hb and SF levels between the two groups before treatment （P>0.05）. After treatment， the Hb level （150.97±3.25） g/L and the SF level （140.29±2.84） μg/L in the observation group were higher than those of the control group [（98.06±4.54） g/L and （54.37±3.15） μg/L， P<0.05].The treatment time （25.75±1.63） d and the total incidence of adverse reactions （2.50%） of the observation group were lower than those of the control group [（30.21±2.84） d and 15.00%， P<0.05]. The total effective treatment rate in the observation group was 95.00%， higher than that of the control group （75.00%）， P<0.05. Conclusion Intravenous drip of iron sucrose in the treatment of iron deficiency anemia can effectively increase the levels of Hb and SF in patients，shorten the treatment time，reduce the incidence of adverse reactions after treatment and increase the total effective rate of treatment.It has high clinical value and is recommended for clinical promotion.

[Key words] Intravenous drip; Oral iron supplements; Iron sucrose; Iron deficiency anemia; Effectiveness; Safety

缺鐵性贫血是由于人体铁元素不足，抑制血红蛋白生成致使红细胞生存需求没有得到满足而引起的贫血，属于临床常见的一种贫血类型。缺铁性贫血发病率高，且多为孕妇和儿童，其由于处在特殊的生长阶段，生理消耗大，易引起铁缺乏，临床表现为晕眩、乏力、易疲劳，严重影响患者的生活与工作，若不及早治疗，患者会由于体内长时间缺乏血红细胞从而造成供血、供氧不足，此类状态极易引发心力衰竭危及患者生命[1]。临床治疗缺铁性贫血一般有两种方法，一种为常用口服铁剂药物治疗，但此类治疗方法起效慢且易引起较多不良反应;另一种方法是静脉补铁，运用该方法治疗患者可以促进铁剂与转铁蛋白的结合，从而快速补充机体所需铁量。本文对缺铁性贫血患者采用静脉滴注蔗糖铁的治疗方法，旨在探讨该类治疗方法对治疗缺铁性贫血的有效性与安全性，并发现该治疗方法相较口服铁剂药物治疗更有效、更安全，建议临床推广，现报道如下。