冻融胚胎移植不同内膜准备方案对不明原因反复种植失败患者妊娠结局的影响

邹志玲 邓智心 陈 博 陈雪梅

摘   要：目的  探討不同冻融胚胎移植内膜准备方案对不明原因反复种植失败患者子宫内膜容受性及妊娠结局的影响。方法  回顾分析2016年7月～2018年7月在东莞市第三人民医院生殖中心不明原因反复种植失败≥2次，行冻融胚胎移植的30例患者的临床资料。本周期自身配对比较，按子宫内膜准备方案分组：其中30周期设为HRT组，25周期设为NC组，38周期设为GnRHa-HRT组。结果  NC组与HRT组、GnRHa-HRT组子宫内膜厚度比较，差异有统计学意义（P<0.05）。GnRHa-HRT组临床妊娠率、胚胎种植率、继续妊娠率明显高于HRT组、NC组，差异有统计学意义（P<0.05）。结论  NC组比HRT组在冻融周期临床妊娠率有提高的趋势，GnRHa-HRT方案可以显著提高冻融周期胚胎反复种植失败患者的临床妊娠率。

关键词：冻融胚胎移植;反复种植失败;内膜准备;子宫内膜容受性

中图分类号：R714                                    文献标识码：A                                DOI：10.3969/j.issn.1006-1959.2018.21.025

文章编号：1006-1959（2018）21-0094-03

Pregnancy Outcome in Patients with Unexplained Recurrent Implantation Failure of Frozen Thawed Embryo Transfer in Different Endometrial Preparation

ZOU Zhi-Ling1，DENG Zhi-xin1，CHEN Bo2，CHEN Xue-mei2

（1.Graduate School of Guangdong Medical University，Zhanjiang 254023，Guangdong，China;

2.Reproductive Center of the Third People's Hospital of Dongguan City，Dongguan 523326，Guangdong，China）

Abstract：Objective  To investigate the effect of Pregnancy outcome in patients with unexplained recurrent implantation failure of frozen thawed embryo transfer in different endometrial preparation. Methods  Retrospective analysis of the failure of repeated planting of ≥2 times in the reproductive center of the Third People's Hospital of Dongguan from July 2016 to July 2018，clinical data of 30 cases of frozen and thawed embryo transfer. According to the endometrial preparation scheme， 30 cycles were divided into HRT group， 25 cycles as NC group and 38 cycles as GnRHa-HRT group.Results  The difference in endometrial thickness between the NC group and the HRT group and the GnRHa-HRT group was statistically significant （P<0.05）.The clinical pregnancy rate， embryo implantation rate and continued pregnancy rate in GnRHa-HRT group were significantly higher than those in HRT group and NC group （P<0.05）. Conclusion  The clinical pregnancy rate of the NC group is higher than that of the HRT group during the freeze-thaw cycle. The GnRHa-HRT program can significantly improve the clinical pregnancy rate of patients with failed embryo implantation in the freeze-thaw cycle.

Key words：Frozen-thawed embryo transfer;Recurrent implantation failure;Endometrial preparation; Endometrial receptivity