IgG4-Related M ikulicz's Disease Associated w ith Thyroiditis：a Case Report and Review of the Literature

Yujiao Zhang，Yi Du，Kaijun Li， Jianfeng He

Department of Ophthalmology， First Affiliated Hospital of Guangxi Medical University， Nanning 530021，China

Introduction

Case report

Figure 1 Computed tomography（CT） and contrast-enhanced computed tomography scans of a 25-year-old man w ith IgG4-related Mikulicz's disease and thyroiditis.In the CT scan， （A）axial view， （B）coronal view and （C）sagittal view （arrows）show bilateral swelling of the lachrymal glands， no hypertrophy of the extraocular muscles， and no compression of the optic nerves； In the contrast-enhanced CT scan， （D） axial view （arrows）shows no enhancement of the lachrymal glands.

Figure 2 Microscopic sections from the left-sided dacryoadenectomy revealed （A）few atrophic acinar cells and a dense lymphoplasmacytic infiltrate and fibrosis， and （B） a mixed infiltrate of immature plasma cells， mature plasma cells， small lymphocytes and scattered eosinophils in lachrymal gland.hematoxylin-eosin； original magnification： （A）×100， （B）×400.

Discussion

Historical cognition

The debate on nomenclature

Etiology and pathogenesis

Pathogenetic characteristics

Clinical exam ination

Diagnosis

Differential diagnosis

Treatment and prognosis

Conclusion