Iontophoretic Delivery of Riboflavin into the Rabbit Cornea：a Primary Study

Na Li， Xiujun Peng， Zhengjun Fan， Yu Xia

1 Chinese PLA Medical School＆ PLA General Hospital，Beijing 100853， China

2 Departmentof Ophthalmology，Navy General Hospital of Chinese PLA，Beijing 100048，China

Materials and methods

Study subjects

Iontophoresis

Instillation after de-epithelium

Slit-lamp exam ination

Corneal stroma button exam ination

Statistical analysis

Results

Discussion

Figure 1 The different yellow colored corneal stroma buttons in four groups.A：0.1%riboflavin-BSS by iontophoresis，B：0.1%riboflavin-saline solution by iontophoresis，C：0.1%riboflavin-distilled water solution by iontophoresis，D：conventional riboflavin instillation after de-epithelialization as controls.

Table 1 Yellow degree of rabbit corneal stroma after iontophoretic delivery by slit lamp exam ination

Table 2 Yellow degree of rabbit aqueous humor after iontophoretic delivery by slit lamp exam ination

Table 3 Yellow degree of rabbit corneal stroma button after iontophoretic delivery