藏药波棱瓜子提取液对四氯化碳致小鼠急性肝损伤保护机理的研究
2014-05-04姜汹李家奎
姜汹++李家奎
摘要：肝损伤是一种常见危害人类和动物健康的疾病。通过研究波棱瓜子（Herpetospermum caudigerum Wall）提取液对四氯化碳所致小鼠急性肝损伤的保护作用，并对其作用机理进行初步分析。试验结果表明，其作用机理与抑制炎性细胞因子的表达等有关，可减轻肝损伤的程度。
关键词：小鼠；肝损伤；四氯化碳；藏药；波棱瓜子（Herpetospermum caudigerum Wall）提取液；保护机理
中图分类号：R284.2 文献标识码：A 文章编号：0439-8114（2014）04-0856-04
Protective Mechanism of Extracts from the Tibetan Medicine Herpetospermum caudigerum Seeds on Acute Liver Injury Mice Induced by Carbon Tetrachlorid
JIANG Xiong1，LI Jia-kui2
（1.Department of Biological and Chemical Engineering， Hubei Three Gorges Polytechnic College， Yichang 443000，Hubei，China；
2.Huazhong Agricultural University， Wuhan 430070，China）
Abstract： Liver injury was a common clinical disease endangering human and animals health caused by various pathogenic factors. The protective mechanisms of the extracts form Tibetan medicine Herpetospermum caudigerum seeds on carban tetrachlorid-induced acute liver injury were studied. The results showed that its mechanism were related with the expression inhibition of inflammatory cytokines.
Key words： mice； liver injury； carbon tetrachloride； tibet medicine； extracts from Herpetospermum caudigerum seeds； protective mechanism
参考文献：
[1] 邓 航，陈重阳.药物的肝毒性[J].华夏医学，2002，15（3）：434-436.
[2] 李隆云，次仁巴珠，占 堆，等.藏药资源的开发与利用[J].中国中药杂志，2001，26（12）：808-810.
[3] 叶常青. 形态计量学在病理学中应用的回顾与展望[J].中华病理学杂志，1990，19（4）：241.
[4] PATEL T， GORES C J. Apoptosis and hepatobiliary disease[J].Hepatology，1995，21（6）：1725-1741.
[5] MATSUNAGA T， HOKARI S， KOYAMA I， et al. NF-kappa B activation in endothelial cells treated with oxidized high-density lipo protein[J]. Biochem Biophysical Res Commun， 2003，303（1）：313-319.
[6] MIRZA A， LIU S L， FRIZELL E. A role for tissue transglutaminase in hepatic injury and fibro genesis， and its regulation by NF-kappa B[J]. Am J Physiol，1997，25（10）：272-281.
[7] LIMURO Y， BRADFORD B U， YANASHINA S， et al.The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic eternal exposure in the rat[J]. Hepatology，2000，31（2）：391.
摘要：肝损伤是一种常见危害人类和动物健康的疾病。通过研究波棱瓜子（Herpetospermum caudigerum Wall）提取液对四氯化碳所致小鼠急性肝损伤的保护作用，并对其作用机理进行初步分析。试验结果表明，其作用机理与抑制炎性细胞因子的表达等有关，可减轻肝损伤的程度。
关键词：小鼠；肝损伤；四氯化碳；藏药；波棱瓜子（Herpetospermum caudigerum Wall）提取液；保护机理
中图分类号：R284.2 文献标识码：A 文章编号：0439-8114（2014）04-0856-04
Protective Mechanism of Extracts from the Tibetan Medicine Herpetospermum caudigerum Seeds on Acute Liver Injury Mice Induced by Carbon Tetrachlorid
JIANG Xiong1，LI Jia-kui2
（1.Department of Biological and Chemical Engineering， Hubei Three Gorges Polytechnic College， Yichang 443000，Hubei，China；
2.Huazhong Agricultural University， Wuhan 430070，China）
Abstract： Liver injury was a common clinical disease endangering human and animals health caused by various pathogenic factors. The protective mechanisms of the extracts form Tibetan medicine Herpetospermum caudigerum seeds on carban tetrachlorid-induced acute liver injury were studied. The results showed that its mechanism were related with the expression inhibition of inflammatory cytokines.
Key words： mice； liver injury； carbon tetrachloride； tibet medicine； extracts from Herpetospermum caudigerum seeds； protective mechanism
参考文献：
[1] 邓 航，陈重阳.药物的肝毒性[J].华夏医学，2002，15（3）：434-436.
[2] 李隆云，次仁巴珠，占 堆，等.藏药资源的开发与利用[J].中国中药杂志，2001，26（12）：808-810.
[3] 叶常青. 形态计量学在病理学中应用的回顾与展望[J].中华病理学杂志，1990，19（4）：241.
[4] PATEL T， GORES C J. Apoptosis and hepatobiliary disease[J].Hepatology，1995，21（6）：1725-1741.
[5] MATSUNAGA T， HOKARI S， KOYAMA I， et al. NF-kappa B activation in endothelial cells treated with oxidized high-density lipo protein[J]. Biochem Biophysical Res Commun， 2003，303（1）：313-319.
[6] MIRZA A， LIU S L， FRIZELL E. A role for tissue transglutaminase in hepatic injury and fibro genesis， and its regulation by NF-kappa B[J]. Am J Physiol，1997，25（10）：272-281.
[7] LIMURO Y， BRADFORD B U， YANASHINA S， et al.The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic eternal exposure in the rat[J]. Hepatology，2000，31（2）：391.
摘要：肝损伤是一种常见危害人类和动物健康的疾病。通过研究波棱瓜子（Herpetospermum caudigerum Wall）提取液对四氯化碳所致小鼠急性肝损伤的保护作用，并对其作用机理进行初步分析。试验结果表明，其作用机理与抑制炎性细胞因子的表达等有关，可减轻肝损伤的程度。
关键词：小鼠；肝损伤；四氯化碳；藏药；波棱瓜子（Herpetospermum caudigerum Wall）提取液；保护机理
中图分类号：R284.2 文献标识码：A 文章编号：0439-8114（2014）04-0856-04
Protective Mechanism of Extracts from the Tibetan Medicine Herpetospermum caudigerum Seeds on Acute Liver Injury Mice Induced by Carbon Tetrachlorid
JIANG Xiong1，LI Jia-kui2
（1.Department of Biological and Chemical Engineering， Hubei Three Gorges Polytechnic College， Yichang 443000，Hubei，China；
2.Huazhong Agricultural University， Wuhan 430070，China）
Abstract： Liver injury was a common clinical disease endangering human and animals health caused by various pathogenic factors. The protective mechanisms of the extracts form Tibetan medicine Herpetospermum caudigerum seeds on carban tetrachlorid-induced acute liver injury were studied. The results showed that its mechanism were related with the expression inhibition of inflammatory cytokines.
Key words： mice； liver injury； carbon tetrachloride； tibet medicine； extracts from Herpetospermum caudigerum seeds； protective mechanism
参考文献：
[1] 邓 航，陈重阳.药物的肝毒性[J].华夏医学，2002，15（3）：434-436.
[2] 李隆云，次仁巴珠，占 堆，等.藏药资源的开发与利用[J].中国中药杂志，2001，26（12）：808-810.
[3] 叶常青. 形态计量学在病理学中应用的回顾与展望[J].中华病理学杂志，1990，19（4）：241.
[4] PATEL T， GORES C J. Apoptosis and hepatobiliary disease[J].Hepatology，1995，21（6）：1725-1741.
[5] MATSUNAGA T， HOKARI S， KOYAMA I， et al. NF-kappa B activation in endothelial cells treated with oxidized high-density lipo protein[J]. Biochem Biophysical Res Commun， 2003，303（1）：313-319.
[6] MIRZA A， LIU S L， FRIZELL E. A role for tissue transglutaminase in hepatic injury and fibro genesis， and its regulation by NF-kappa B[J]. Am J Physiol，1997，25（10）：272-281.
[7] LIMURO Y， BRADFORD B U， YANASHINA S， et al.The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic eternal exposure in the rat[J]. Hepatology，2000，31（2）：391.
