212005 The oncologic safety of breast-conserving surgery for breast ductal carcinoma in situ

/Zhang Qingde(张庆德，Dept Gen Surg，Beijing Shijingshan Hosp，Beijing 100043)…∥Chin J Gen Surg.-2011，26(9).-74～750

ObjectiveTo evaluate the safety of breast-conserving surgery for ductal carcinoma in situ(DCIS).MethodsOne hundred and nineteen patients with pathologically confirmed DCIS were analyzed retrospectively.The relationship among local recurrence and distant metastasis with relevant factors including surgical procedure，age，tumor size，estrogen/progesterone status and human epithelial receptor 2(HER-2)status were analyzed by univariate and multivariate methods.ResultsIn this study 48 patients received breast conserving surgery，71 patients received mastectomy.All patients were followed up 7-132 months(median 35 months).Chest wall recurrence was found in mastectomy group in one case and none in ipsilateral breast tumor recurrence(IBTR)in breast conservation group(P=0.384).Two patients had distant metastasis in mastectomy group，and one patient in breast conserving group(P=0.383).The three year diseasefree survival(DFS)were 100%and 94.4%in breast conserving and mastectomy groups respectively(P=0.255).Univariate analysis showed that age(＜ 40 years)was the risk factor for distant metastasis(P=0.035)，a factor not confirmed by multivariate analysis(P=0.086).ConclusionThere is no significant difference on local recurrence and distant metastasis between breast conserving surgery and mastectomy for DCIS of the breast.14 refs，1 fig，3 tabs.