COMMENTARY

1. Developing high quality chemical probes targeting ubiquitin-specific proteases

REVIEW

1. Role of calcium-activated potassium channels in neuronal pacemaker activity
2. Effects of calcium channel blockers on growth cone and their clinical implications
3. Pathological role of transient receptor potential melastatin member 2 channel in neurodegenerative diseases and Alzheimer disease
4. Role of dynamic related protein 1 in mitochondrial dynamic dysfunction in Alzheimer disease
5. Drug reward memory:implication from drug-induced conditioned place preference model
6. Incretin hormone glucagon-like peptide 1 and gut microbiota

1. GUEST EDITOR′S COMMENTARY
2. INSTRUCTIONS FOR AUTHORS
3. Brief Introduction of the Executive Committee of the Chinese Pharmacological Society North America Chapter(CPSNAC) and the Specialists in This Issue

ORIGINAL ARTICLES

1. Reversal effects of desipramine on resistance of U251/TR cells to temozolomide