Evaluating pediatric ureteropelvic junction obstruction: Dynamic magnetic resonance urography vs renal scintigraphy 99mtechnetium mercaptoacetyltriglycine

Yousuf Al-Shaqsi,Matthieu Peycelon,Annabel Paye-Jaouen,Elisabeth Carricaburu,Anca Tanase,Christine Grapin-Dagorno,Alaa El-Ghoneimi

Abstract BACKGROUND Ureteropelvic junction obstruction (UPJO) is a common congenital urinary tract disorder in children.It can be diagnosed as early as in utero due to the presence of hydronephrosis or later in life due to symptomatic occurrence.AIM To evaluate the discrepancy between dynamic contrast-enhanced magnetic resonance urography (dMRU) and scintigraphy 99m-technetium mercaptoacetyltriglycine (MAG-3) for the functional evaluation of UPJO.METHODS Between 2016 and 2020,126 patients with UPJO underwent surgery at Robert Debré Hospital.Of these,83 received a prenatal diagnosis,and 43 were diagnosed during childhood.Four of the 126 patients underwent surgery based on the clinical situation and postnatal ultrasound findings without undergoing functional imaging evaluation.Split renal function was evaluated preoperatively using scintigraphy MAG-3 (n=28),dMRU (n=53),or both (n=40).In this study,we included patients who underwent surgery for UPJO and scintigraphy MAG-3+dMRU but excluded those who underwent only scintigraphy MAG-3 or dMRU.The patients were divided into groups A (＜ 10% discrepancy) and B (＞ 10% discrepancy).We examined the discrepancy in split renal function between the two modalities and investigated the possible risk factors.RESULTS The split renal function between the two kidneys was compared in 40 patients (28 boys and 12 girls) using scintigraphy MAG-3 and dMRU.Differential renal function,as determined using both modalities,showed a difference of ＜ 10% in 31 children and ＞ 10% in 9 children.Calculation of the relative renal function using dMRU revealed an excellent correlation coefficient with renal scintigraphy MAG-3 for both kidneys.CONCLUSION Our findings demonstrated that dMRU is equivalent to scintigraphy MAG-3 for evaluating split renal function in patients with UPJO.

Key Words: Uteropelvic junction obstruction;Scintigraphy 99m-technetium mercaptoacetyltriglycine;Magnetic resonance imaging;Dynamic contrast-enhanced magnetic resonance urography

lNTRODUCTlON

Ureteropelvic junction obstruction (UPJO),the most common urinary tract disorder among children,is observed in all pediatric age groups[1,2].It can be diagnosed during the neonatal period due to the presence of prenatal dilation of the upper urinary tract or later in life due to symptomatic occurrence.However,most cases are detected during the perinatal period[1,3].

Renal ultrasound is generally used to detect and follow up hydronephrosis,whereas renal scintigraphy using dimercaptosuccinic acid or 99m-technetium mercaptoacetyltriglycine (MAG-3) evaluates renal function and obstruction,respectively[4,5].Computed tomography can be an option for adolescents and young adults to assess obstruction and identify any aberrant vessels as a cause of UPJO or for postoperative follow-up[4].Although these techniques can clearly assess obstructions,they cannot predict the progressive loss of renal function or determine which patients will benefit from surgery.

The decision for surgical intervention to correct UPJO is controversial;while some surgeons suggest early intervention,others promote a wait-and-see approach[5,6].Many urologists follow the sonographic diagnosis of hydronephrotic kidney and use declining renal function in functional imaging studies as an indication for surgery[6].Asymptomatic patients with UPJO should only be treated if there is evidence of asymmetric function,functional deterioration,or hydronephrosis[4-7].Identifying and surgically correcting UPJO in these patients before the occurrence of nephron loss is essential.

Renal scintigraphy is considered the gold standard technique for evaluating anatomical obstruction and measuring split renal function in children and adults,driving therapeutic decisions[8-10].However,dynamic contrast-enhanced magnetic resonance urography (dMRU) has recently been proposed as an alternative technique for evaluating the drainage curve and split renal function in obstructive uropathy,without requiring ionizing radiation[11-13].The use of dMRU to obtain both anatomical and functional information in a single examination without radiation is beneficial,especially in the follow-up of young patients[14,15].

This study aimed to evaluate the discrepancies between dMRU and renal scintigraphy MAG-3 for the functional evaluation of UPJO in children.We hypothesized that dMRU and renal scintigraphy MAG-3 would provide similar information regarding renal function.

MATERlALS AND METHODS

This retrospective cohort study included patients with UPJO who underwent surgery and renal scintigraphy MAG-3+dMRU at Roberts Debré Children University Hospital between January 2016 and March 2020 but excluded those who underwent only renal scintigraphy MAG-3 or dMRU (Figure 1).This retrospective study was conducted in accordance with the ethical principles outlined in the Helsinki Declaration.Due to the nature of the study involving analysis of deidentified data from existing medical records,formal ethical approval from an institutional review board was not sought.However,efforts were made to ensure patient confidentiality and respect for individual privacy throughout the study process.

Figure 1 Overview of the study enrollment process. dMRU: Dynamic contrast-enhanced magnetic resonance urography;MAG-3: 99m-technetium mercaptoacetyltriglycine.

First,all patients underwent renal ultrasonography for the initial radiological evaluation of renal pelvic dilatation (Table 1).Those suspected of UPJO were then subjected to further renal function evaluations using scintigraphy MAG-3 or dMRU based on the available modality and the radiologist’s experience.As these patients did not require surgical correction of the UPJO,they were followed up in the clinic with renal ultrasonography.However,in situations where the patients had major dilatation of the renal pelvis on ultrasound findings during follow-up,we requested another modality for comparisoni.e.,if the patient had initially underwent scintigraphy MAG-3,we requested dMRU,and vice versa (Table 2).

Table 1 Characteristics of the entire study cohort,n (%)

Table 2 Decision-making for surgical correction of ureteropelvic junction obstruction,n (%)

We then examined the discrepancies in split renal function assessments between the two radiological modalities.To assess split renal function in both kidneys,functional dMRU results were correlated with the reference standard of MAG-3 scintigraphy.The patients were divided into two groups: Group A,the discrepancy between renal scintigraphy MAG-3 and dMRU was ＜ 10% (n=31),and Group B,the discrepancy was ＞ 10% (n=9).In addition,we investigated the potential risk factors for these discrepancies,including sex,age at diagnosis,preoperative febrile urinary tract infection,presence of vesicoureteral reflux,and associated anomalies of the urinary tract,such as duplication of the urinary system,single kidney,and horseshoe kidney (Table 3).

Table 3 Characteristics of the patients enrolled in the study (n=40),n (%)

dMRU protocol

dMRU is performed as an outpatient study or in the day care unit,depending on the child’s age and the need for sedation.Children ＜ 7 years of age required sedation and observation during daycare for a few hours before discharge from the hospital.Chloral hydrate 50-75 mg/kg PO was administered to children ＜ 1 year of age 30-60 min before the procedure and repeated for 30 min if necessary.In older children,we administered intrarectal pentobarbital (5 mg/kg) and alimemazine (2 mg/kg) 1-2 h before the procedure.

Sedation was induced and monitored by a trained pediatric sedation nurse.The patients were continuously monitored for oxygen saturation and pulse rate.All children were hydrated before the study with Ringer’s lactate solution (10 mL/kg) and premedicated with phenobarbitone (5 mg/kg) administered intrarectally 30 min before the procedure.First,T2-weighted imaging sequences [static magnetic resonance urography (MRU)] were performed to evaluate the entire urinary tract system.Next,furosemide (1 mg/kg) was administered intravenously 1 min after the injection of gadolinium-DTPA 0.05 mmol/kg.Then,routine T1 imaging (excretory MRU) of the kidneys,ureters,and bladder was performed 10 min after furosemide injection.Sequential dynamic contrast-enhanced imaging with a time resolution of 15 s was performed using the volumetric gradient echo technique covering the entire urinary tract.This volumetric sequence was repeated continuously for the initial 3 min following a bolus injection of gadolinium-DTPA 0.05 mmol/kg.Datasets were then obtained at 1 min intervals for a total of 20 min.Renal and ureteral transition times were measured,and the split renal function between the two kidneys was calculated using ImageJ software.

Scintigraphy MAG-3 protocol

A urinary catheter was placed,and the children were orally hydrated with 10-20 mL/kg of water 30-40 min before the study.Posterior dynamic acquisition was performed after intravenous injection of MAG-3 3.7 MBq/kg and furosemide (1 mg/kg).The patients were placed in the supine position with their backs facing the camera.Serial 15-30 s images were acquired for 30-60 min,depending on the technique chosen.In the dynamic renal study,careful evaluation of the parenchymal phase using the Patlak-Rutland method revealed split renal function.Cortical transit time and collection system dilatation were examined during the excretory phase (initial 2-4 min).Baseline images of the diuretic phase were used to assess the diuretic effects.

Statistical analysis

Descriptive statistics were performed using Fisher’s exact test or theχ2tests for categorical variables,Student’st-test for parametric continuous data (presented as mean and standard deviation),and the Mann-Whitney test for nonparametric continuous data [presented as median and interquartile range (IQR)].A positive correlation coefficient was observed atr＞ 0.Potential risk factors for discrepancies in renal function between renal scintigraphy MAG-3 and dMRU were analyzed using univariate analysis,withP＜ 0.05 considered statistically significant.On exploratory analysis,all variables with values ofP＜ 0.20 on univariate analysis were assessed for a possible association with the discrepancy in renalfunction between renal scintigraphy MAG-3 and dMRU on multivariate Cox regression.

RESULTS

A total of 126 patients were included in the study.Of these patients,83 were diagnosed prenatally,and 43 (34%) were diagnosed later during childhood (median age,9 years).Four (3%) of 126 patients underwent surgery based on clinical evaluation and postnatal ultrasound findings,without undergoing any functional imaging evaluation.Split renalfunction was evaluated preoperatively using an isotope renal scan [n=28 (22%)],dynamic MRI [n=54 (43%)],or both [n=40 (32%)].The most common presentation of UPJO was prenatal hydronephrosis in 83 (66%) patients,followed by lumbar pain in 22 (17%) and urinary tract infections in 21 (16%) (P＞ 0.05).Of the 126 patients,4 (3%) had duplex systems,1 had UPJO in a horseshoe kidney,3 (2%) had vesicoureteral reflux,and 3 (3%) had urinary calculi (P＜ 0.05;Table 1).

Split renal function was compared in 40 patients [28 boys and 12 girls (P＞ 0.05)] using scintigraphy MAG-3 and dMRU.Of these,31 (77%) received a prenatal diagnosis,and 9 (23%) were diagnosed during later childhood (P＞ 0.05).Differential renal function,as determined by scintigraphy MAG-3 and dMRU,differed by ＜ 10% in 31 children and ＞ 10% in 9 children (P＞ 0.05;Table 3).

All patients underwent pyeloplasty [right side (n=13) and left side (n=27);P＞ 0.05] at a median age of 30 months (IQR,14-127 months).Thirty-four patients underwent laparoscopy (retroperitoneoscopy or robot-assisted retroperitoneoscopy) while the other six underwent lumbotomy.Most patients (95%) had good clinical outcomes and satisfactory results on ultrasonography during follow-up [median,12 months (IQR,5-20 months)],and there were two cases (5%) of persistent renal pelvic dilatation without renal function degradation.Calculation of relative renal function by dMRU revealed an excellent correlation coefficient with renal scintigraphy MAG-3 for both kidneys (r=0.84 andr=0.82,respectively;Figure 2).

Figure 2 Relative differential function results on dynamic contrast-enhanced magnetic resonance urography vs scintigraphy. A: Relative differential function results of left kidney on dynamic contrast-enhanced magnetic resonance urography (dMRU) vs scintigraphy (correlation coefficient=0.84);B: Relative differential function results of right kidney on dMRU vs scintigraphy (correlation coefficient=0.82).MRU: Magnetic resonance urography.

DlSCUSSlON

Congenital uropathy is a wide-spectrum entity that varies from asymptomatic to self-resolving and life-threatening conditions.Hydronephrosis is the most common congenital anomaly detected using ultrasonography during the prenatal period.While most cases of grade 1 and grade 2 hydronephrosis (96%) spontaneously resolve in the first year of life,a minority of patients develop UPJO[16].Dynamic renal scintigraphy MAG-3 is considered the gold standard for estimating differential renal function and diagnosing obstructions in children.However,in recent times,dMRU has emerged as an alternative technique for evaluating the drainage curve and split renal function in obstructive uropathy[11-13].dMRU provides excellent anatomical information on the urinary tract and enables the precise exclusion of urinary tract obstruction,without requiring ionizing radiation[16].It produces high-resolution images arising from the accumulation of bright contrast content in the collection system and ureter,which enables identification of the ureter distal to the obstruction site[15].Since 2000,dMRU has been the main modality for evaluating renal function at the Robertson Debré Children University Hospital.However,despite its benefits,dMRU is not widely used because it is expensive and there is a lack of trained pediatric radiologists.

Few studies have investigated the diagnostic value of dMRU for obstructive uropathy.For instance,Perez-Brayfieldet al[13] reported that dMRU provides superior anatomical details compared with sonography and nuclear scintigraphy.Although the procedure requires sedation in all cases,it delivers no ionizing radiation to the infant or child.In this study,we examined the discrepancy in functional evaluation between dynamic contrast-enhanced MRU and renal scintigraphy MAG-3 in patients with UPJO who underwent surgery at our hospital over the last 4 years.From a total of 126 patients in the study,only 40 were included in the final analysis.We found a positive correlation coefficient in the relative differential of split renal function between the two modalities.Similarly,El-Nahaset al[12] reported that dMRU analysis of renal function had comparable results to those obtained with renal scintigraphy but superior spatial and contrast resolution.dMRU may be more sensitive than renal scintigraphy for analyzing poorly functional renal collecting systems.In addition to the earlier advantages of dMRU,we found that it is equivalent to nuclear medicine in evaluating split renal function and obstruction (Table 4).Thus,dMRU is a feasible radiological modality for the functional and anatomical evaluation of UPJO.Moreover,it is safe,accurate,and does not require exposure to ionizing radiation.However,the procedure requires sedation and short-term hospitalization.The limitations of this study include a small sample size from a single institution.The requirement for sedation during dMRU presents a practical challenge.Future implications emphasize the need for larger multicenter studies to confirm these findings,while advancements in imaging technology hold promise for enhancing the accessibility and viability of dMRU as a gold standard diagnostic tool for UPJO.

Table 4 Discrepant characteristics of group A and group B,n (%)

CONCLUSlON

dMRU is equivalent to scintigraphy MAG-3 for evaluating split renal function in UPJO cases of all pediatric age groups.We found that the discrepancies and similarities in renal function were not significantly related to age at diagnosis,sex,or pyelonephritis.We believe that dMRU is an excellent alternative modality for the anatomical and functional evaluation ofchildren with UPJO.However,larger multicenter studies are required to strengthen and consolidate our findings.

ARTlCLE HlGHLlGHTS

Research background

Ureteropelvic obstruction is a common pediatric condition,which can be due to congenital internal obstruction or external obstruction secondary to crossing vessels.This study aims to encourage the use of dynamic contrast-enhanced magnetic resonance urography (dMRU) as a modality,measuring renal function as effectively as 99m-technetium mercaptoacetyltriglycine (MAG-3) and providing a good anatomical study in cases of obstruction due to crossing vessels.

Research motivation

dMRU proves advantageous as an alternative modality for ureteropelvic junction obstruction (UPJO).However,enhanced accessibility and cost-effectiveness can be achieved through advancements in magnetic resonance imaging technology.

Research objectives

The optimal imaging modalities for preoperative functional and anatomical assessment of UPJO in pediatric patients.

Research methods

Analysis of data in patients who underwent surgery for UPJO and had both dMRU and scintigraphy MAG-3 for split renal function assessment.

Research results

dMRU is equivalent to scintigraphy MAG-3 for evaluating split renal function in UPJO cases of all pediatric age groups.Future implications emphasize the need for larger multicenter studies to confirm findings,while advancements in imaging technology hold promise for enhancing the accessibility and viability of dMRU as a gold standard diagnostic tool of UPJO.

Research conclusions

dMRU is an excellent alternative modality for the anatomical and functional evaluation of children with UPJO.A large sample size is required to confirm this hypothesis.

Research perspectives

To enhance the accessibility and viability of dMRU.

FOOTNOTES

Author contributions:Al-Shaqsi Y contributed to writing and editing;Peycelon M contributed to design and editing;Paye-Jaouen A,Carricaburu E,Tanase A,and Grapin-Dagorno C contributed to data collection and analyzing data;El-Ghoneimi A contributed to design and editing.

lnstitutional review board statement:This retrospective study was conducted in accordance with the ethical principles outlined in the Helsinki Declaration.Due to the nature of the study involving analysis of de-identified data from existing medical records,formal ethical approval from an institutional review board was not sought.However,efforts were made to ensure patient confidentiality and respect for individual privacy throughout the study process.

lnformed consent statement:Informed consent was waived for this retrospective study as it involved the analysis of de-identified data obtained from existing medical records.The study was conducted in accordance with ethical principles and guidelines outlined in the Helsinki Declaration.

Conflict-of-interest statement:All the authors report no relevant conflicts of interest for this article.

Data sharing statement:No additional data are available.

Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers.It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license,which permits others to distribute,remix,adapt,build upon this work non-commercially,and license their derivative works on different terms,provided the original work is properly cited and the use is non-commercial.See: https://creativecommons.org/Licenses/by-nc/4.0/

Country/Territory of origin:France

ORClD number:Yousuf Al-Shaqsi 0000-0003-1846-3129.

S-Editor:Li L

L-Editor:Webster JR

P-Editor:Zhao S