心肌标志物、MPV、PDW和血清sCD36、sCD40L对冠心病的诊断价值

那轩与 范越男 彭程 王柏山 张程

[关键词] 心肌标志物;血常规;冠心病;心肌肌钙蛋白

[中图分类号] R541          [文献标识码] A          [文章编号] 1673-9701（2021）25-0020-04

Diagnostic value of myocardial markers， MPV， PDW， serum sCD36 and sCD40L for coronary heart disease

NA Xuanyu   FAN Yuenan   PENG Cheng   WANG Baishan   ZHANG Cheng

Department of Laboratory Medicine， Affiliated Hospital of Liaoning University of Traditional Chinese Medicine， Shenyang   110031， China

[Abstract] Objective To explore the diagnostic value of myocardial markers，MPV，PDW， serum sCD36， sCD40L and other indicators for coronary heart disease. Methods A total of 150 patients with coronary heart disease treated in our hospital from June 2018 to July 2019，and 150 healthy medical examiners were selected. They were tested for myocardial markers，blood count， sCD36 and sCD40L，to compare the diagnostic coincidence rates of different diagnosis methods. Results The indexes of cTnI， CK-MB and cTnT in the observation group were significantly higher than those in the control group，with significant difference（P<0.05）. The RDW index in the observation group were significantly higher than that in the control group，with significant difference（P<0.05）. There were no significant differences in blood count results， including PDW， PLT， MPV and PCT between the two groups（P>0.05）. The expression levels of serum sCD36 and sCD40L in the observation group were significantly higher than those in the control group，with significant difference（P<0.001）. Conclusion  The myocardial markers cTnI， CK-MB and cTnT， RDW， and serum sCD36 and sCD40L all change abnormally in patients with coronary heart disease. They can be used as disease diagnosis indicators.

[Key words] Myocardial markers; Blood count; Coronary heart disease; Cardiac troponin

冠心病為常见慢性疾病，主要指冠状动脉粥样硬化所引发的冠状动脉管腔狭窄及阻塞性疾病，患者常会出现心肌缺血、缺氧反应，有较高致死率，需早期诊断、治疗。患者临床多表现为胸痛、心绞痛，治疗不当则会危及生命安全。临床主要诊断方式为冠状动脉造影、超声心动图等，虽然诊断符合率较高，但选择有效的辅助性诊断方式也十分重要。研究发现，血常规和心肌标志物均可用于冠心病诊断，但具体诊断效果却并无全方位分析[1]。为提升疾病诊断符合率，现选取我院患者和体检人员为研究对象，分析患者心肌标志物心肌肌钙蛋白I（Cardiac troponin I，cTnI）、肌酸激酶同工酶（Creatine kinase isoenzyme，CK-MB）、心肌肌钙蛋白T（Cardiac troponin T，cTnT）、平均血小板体积（Mean platelet volume，MPV）、血小板体积分布宽度（Platelet volume distribution width，PDW）、红细胞体积分布宽度（Red blood cell volume distribution width，RDW）、血清可溶性CD36（Soluble CD36，sCD36）及可溶性CD40配体（soluble CD40 ligand，sCD40L）等指标，探讨不同诊断方式效果，现报道如下。

1 资料与方法