Estimated impact of introduction of new diagnostic criteria for gestational diabetes mellitus

Leon de Wit,Anna B Zijlmans,Doortje Rademaker,Christiana A Naaktgeboren,J Hans DeVries,Arie Franx,Rebecca C Painter,Bas B van Rijn

Leon de Wit,Department of Obstetrics and Gynaecology,University Medical Center Utrecht,Utrecht 3584 EA,Netherlands

Anna B Zijlmans,Department of Obstetrics and Gynaecology,Gelderse Vallei Hospital,Ede 6716 RP,Netherlands

Doortje Rademaker,Department of Obstetrics and Gynaecology,Amsterdam University Medical Centers- Location AMC,Amsterdam 1105 AZ,Netherlands

Christiana A Naaktgeboren,Rebecca C Painter,Department of Obstetrics and Gynaecology,Amsterdam University Medical Centers–Location AMC,Amsterdam 1105 AZ,Netherlands

J Hans DeVries,Department of Endocrinology,Amsterdam University Medical Centers–Location AMC,Amsterdam 1105 AZ,Netherlands

Arie Franx,Bas B van Rijn,Department of Obstetrics and Fetal Medicine,Erasmus MC Sophia Children Hospital,Rotterdam 3015 GD,Netherlands

Abstract BACKGROUND Implementation of new diagnostic criteria for gestational diabetes mellitus (GDM) are still a subject of debate,mostly due to concerns regarding the effects on the number of women diagnosed with GDM and the risk profile of the women newly diagnosed.AIM To estimate the impact of the World Health Organization (WHO) 2013 criteria compared with the WHO 1999 criteria on the incidence of gestational diabetes mellitus as well as to determine the diagnostic accuracy for detecting adverse pregnancy outcomes.METHODS We retrospectively analyzed a single center Dutch cohort of 3338 women undergoing a 75 g oral glucose tolerance test where the WHO 1999 criteria to diagnose GDM were clinically applied.Women were categorized into four groups:non-GDM by both criteria,GDM by WHO 1999 only (excluded from GDM),GDM by WHO 2013 only (newly diagnosed) and GDM by both criteria.We compared maternal characteristics,pregnancy outcomes and likelihood ratios for adverse pregnancy outcomes.RESULTS Retrospectively applying the WHO 2013 criteria increased the cohort incidence by 13.1%,from 19.3% to 32.4%.Discordant diagnoses occurred in 21.3%;4.1% would no longer be labelled as GDM,and 17.2% were newly diagnosed.Compared to the non-GDM group,women newly diagnosed were older,had higher rates of obesity,higher diastolic blood pressure and higher rates of caesarean deliveries.Their infants were more often delivered preterm,large-for-gestational-age and were at higher risk of a 5 min Apgar score <7.Women excluded from GDM were older and had similar pregnancy outcomes compared to the non-GDM group,except for higher rates of shoulder dystocia (4.3% vs 1.3%,P = 0.015).Positive likelihood ratios for adverse outcomes in all groups were generally low,ranging from 0.54 to 2.95.CONCLUSION Applying the WHO 2013 criteria would result in a substantial increase in GDM diagnoses.Newly diagnosed women are at increased risk for pregnancy adverse outcomes.This risk,however,seems to be lower than those identified by the WHO 1999 criteria.This could potentially influence the treatment effect that can be achieved in this group.Evidence on treatment effects in newly diagnosed women is urgently needed.

Key Words:Diagnostic criteria;Gestational diabetes;Glucose tolerance test;Incidence;Pregnancy outcome

INTRODUCTION

Gestational diabetes mellitus (GDM),defined as hyperglycemia first diagnosed in pregnancy that is not overt diabetes mellitus,is an increasing health problem worldwide and associated with substantial adverse maternal and fetal effects[1].Adequate recognition,diagnosis and treatment of GDM improves health outcomes in mothers and their offspring[2-5].Diagnostic criteria for GDM vary globally and are still much debated[6-9].Based on the 2008 Hyperglycemia and Adverse Pregnancy Outcome study,new criteria were developed by the International Association of Diabetes in Pregnancy Study Groups,which were adopted by the World Health Organization (WHO) in 2013[1,10,11].Uniform implementation of the revised criteria is currently held back due to ongoing concerns regarding their impact on prevalence and associated health care costs[12,13].Previous studies have shown a substantial absolute increase of GDM prevalence ranging from 0.9% to as much as 25.9%,following conversion from the 1999 to the 2013 criteria,with limited data on their direct effect on pregnancy outcomes[12,14-28].

The impact of the widening of disease definitions,as is the case with the proposed changes in diagnostic criteria for GDM,has gained attention due to concerns regarding possible overdiagnosis,medicalization and overtreatment[12,13].The WHO 2013 criteria propose a lower fasting,a higher post load glucose value and an additional one hour post load glucose value compared to the 1999 criteria.This leads to a newly diagnosed group of women based on their fasting glucose and a group of women no longer qualifying for the diagnosis based on their two-hour glucose value.Apart from an overall expected increase of the incidence of GDM as a result of the new criteria,the composition of the group of women labeled as GDM is therefore also likely to change.This is of interest in the assessment of incremental health benefits,potential harm and cost-effectiveness,which must be balanced for both individual patients and society prior to introduction of new criteria.

The aim of this study was to assess the potential impact of adopting the WHO 2013 criteria on the incidence of GDM.We sought to investigate the differences in patient characteristics of women with a discordant diagnosis of GDM between criteria,whether pregnancy outcomes in the newly diagnosed group differ from the nondiabetic population and to study the diagnostic value of the different criteria for adverse pregnancy outcomes.

MATERIALS AND METHODS

Setting and study population

We conducted a retrospective cohort study including all pregnant women at risk for GDM,booked for an oral glucose tolerance test (OGTT) and receiving obstetric care in the University Medical Center Utrecht from 1 August 2011–27 October 2016.This study was exempt from approval of the Medical Research Ethics Committee of the University Medical Center Utrecht (reference number 16-711/C),which granted a waiver after reviewing the protocol because the Dutch Medical Research Involving Human Subjects Act did not apply to this study.Therefore,no individual informed consent was required for this study.Data was anonymized and collectively analyzed to ensure there was no risk of disclosure of the identity of included subjects.

Women were identified using laboratory data,which were cross-referenced with obstetric patient files.Data was collectedperpregnancy,meaning that women with OGTTs in multiple pregnancies during the study period were included as separate cases.Women undergoing an OGTT for another reason than to test for GDM were excluded.

Screening for GDM

Pregnant women with one or more predefined risk factors underwent screening between 24 and 28 wk of gestation by means of a 2-point 75 g OGTT[29].Risk factors following Dutch national guidelines that prompted screening included a history of GDM,body mass index (BMI) >30 kg/m2at intake,previous delivery of a child with a birth weight >95thcentile or >4500 g,a first-degree family member with diabetes,ethnic predisposition,history of unexplained stillbirth or polycystic ovarian syndrome[29].Those with a history of GDM underwent screening at 16 wk of gestation,which was repeated at 24-28 wk if initially normal.Finally,women with clinical signs suggestive for GDM (e.g.,polyhydramnios,suspected fetal macrosomia or polydipsia) could undergo OGTT testing at any gestational age.

Classification of OGTT results

Based on the OGTT results,we retrospectively classified the women into four groups:(1) no GDM according to both the WHO 1999 and WHO 2013 criteria:fasting glucose <5.1 mmol/L and 2-h post load glucose <7.8 mmol/L;(2) GDM according to the WHO 1999 criteria but not the WHO 2013 criteria:fasting glucose <5.1 mmol/L and 2-h post load glucose ≥ 7.8 mmol/L but <8.5 mmol/L;(3) GDM according to the WHO 2013 criteria but not the WHO 1999 criteria:fasting glucose ≥ 5.1 mmol/L but <7.0 mmol/L and 2-h post load glucose <7.8 mmol/L;and (4) GDM according to both criteria:either fasting glucose ≥ 7.0 mmol/L and/or 2-h post load glucose ≥ 8.5 mmol/L alone,or a combination of fasting glucose ≥ 5.1 mmol/L and 2-h post load glucose ≥ 7.8 mmol/L.

Groups 1 and 4 were groups where both the assessed criteria agree,and in groups 2 and 3 there is a discordance in diagnosis.For this study,group 1 was labelled non-GDM.Group 2 and 4 received treatment for GDM.Group 2 represents the group of women who would no longer be labelled as GDM with the new criteria,and group 3 consists of the newly added women that would switch from non-GDM to GDM.Some women had received more than one OGTT in a single pregnancy,for instance due to newly suspected macrosomia occurring after an initial negative routine screening.Results from all OGTTs were considered when classifying women into group 1 to 4 (Supplemental table 1).The 1-h post load glucose threshold of ≥ 10.0 mmol/L of the WHO 2013 criteria was not used in the classification,as these results were not available.

Routine care for GDM

Women started treatment if diagnosed with GDM according to the WHO 1999 criteria,comprising all women in groups 2 and 4.They received personalized dietary advice and were instructed to self-monitor fasting and postprandial glucose concentrations by finger stick at least twice a week.Target glucose values were fasting ≤ 5.3 mmol/L and 2-h postprandial ≤ 6.7 mmol/L.In case of insufficient glycemic regulation after 1 wk to 2 wk of dietary intervention,insulin treatment was initiated.Women with normal OGTT results according to the WHO 1999 criteria,e.g.,groups 1 and 3,received care as usual.

Data collection

OGTT results,patient characteristics and pregnancy outcomes were collected from electronic patient files.Given that women without risk factors are not screened for GDM and that OGTT screening also took place in laboratories outside the University Medical Center Utrecht,we were not able to provide a population or regional incidence estimate of GDM but rather a cohort incidence.

Patient characteristics and outcomes

We calculated BMI using prepregnancy reported height and weight.Regarding ethnicity,Hindustan was used for women from the South Asian/Indian subcontinent or Surinamese descent.Mediterranean ethnicity comprised mostly women originating from Turkey and Morocco.Small-for-gestational-age (SGA) and large-for-gestationalage (LGA) were defined as neonatal birth weight <10thand >90thpercentile for gestational age,respectively,using the Dutch reference curves[30].Preterm birth was defined as a gestational age at birth <37 wk,which was further divided in either spontaneous or indicated preterm birth.Individual diagnoses of gestational hypertension and preeclampsia were not available.As a proxy for hypertensive disorders during the pregnancy,the highest measured diastolic blood pressure was used for analysis.

Statistical analysis and reporting of data

The statistical methods of this study were reviewed by Christiana Naaktgeboren from the Department of Obstetrics and Gynaecology,Amsterdam University Medical Centers–Location AMC.GDM incidence in the cohort was calculated by applying both the WHO 1999 and 2013 criteria.We produced 2 × 2 contingency tables to display the number of women in groups 1 through 4,based on their OGTT results.Patient characteristics and pregnancy outcomes were reported and analyzed using groups 1 to 4 as determinants.Continuous variables were reported as mean ± SD or as median and interquartile range depending on distribution.Number and percentage were reported for categorical variables.Differences between groups were assessed using group 1 (non-GDM) as the reference group.We compared continuous variables using the independent t-test or Mann-Whitney U test and the χ-square test or Fisher’s exact test for categorical data.Furthermore,we assessed the diagnostic value of the OGTT by calculating positive and negative likelihood ratios for adverse obstetric and neonatal outcomes for groups 2 to 4,using group 1 as the reference group[31,32].APvalue <0.05 was considered statistically significant.Analyses were performed using SPSS 25.0 for Windows (IBM SPSS,Chicago,IL,United States).

RESULTS

In the study period 3628 women were scheduled for an OGTT.Of these,290 were excluded:67 were planned for an OGTT but did not undergo the test and another 223 were excluded because they underwent an OGTT for other reasons than to test for GDM.In total we included 3338 women for analysis (Figure 1).

Effect of WHO 2013 criteria on GDM incidence

Of the 3338 included women,643 (19.3%) were diagnosed with GDM using the WHO 1999 criteria.Retrospectively applying the WHO 2013 criteria resulted in 1082 women diagnosed with GDM,corresponding to a cohort incidence of 32.4% (Figure 1).This is equivalent to a relative increase of the incidence of 68%.A total of 2219 women (63.5%) had normal glucose tolerance according to both criteria (group 1),506 women (15.2%) were diagnosed with GDM by both criteria (group 4),137 women (4.1%) were diagnosed by WHO 1999 criteria only (group 2) and 576 (17.2%) by the WHO 2013 criteria only (group 3) (Figure 1).

Figure 1 Cohort selection and flowchart of inclusions.

Maternal characteristics

Maternal characteristics are presented in Table 1.Compared to group 1 (non-GDM) women in group 3 (newly added by the WHO 2013 criteria) were older (33.0vs32.3 years,P= 0.002) and had a higher median prepregnancy BMI (29.0 kg/m2vs24.3 kg/m2,P<0.001).BMI distribution was significantly different (P<0.001),with a higher frequency of BMIs of 30-35 and ≥ 35 kg/m2in the newly added group compared to the non-GDM women (24.4%vs10.4% and 19.0%vs5.9%,respectively).There were no differences in ethnicity between the groups.In group 3 smoking during pregnancy was reported more often (16.8%vs13.3%,P= 0.031),and women were less often primiparous (29.7%vs37.9%,P<0.001).

Table 1 Patient characteristics per group based on classification of oral glucose tolerance test results

Table 2 Pregnancy outcomes per group based on classification of oral glucose tolerance test results

The women in group 2 (GDM according to the WHO 1999 but not the WHO 2013 criteria) had a higher median age compared to the non-GDM group (34.1vs32.3 years,P<0.001) and more often were ≥ 35 years of age (40.1%vs29.0%,P= 0.002).Median BMI and BMI distribution as well as other baseline characteristics were similar to the non-GDM group.

The women in group 4 (GDM according to both criteria) had a significantly higher median age,were more often ≥ 35 years of age,had a higher prepregnancy BMI and had higher rates of obesity compared to the non-GDM women.In this group Caucasian ethnicity was less frequent,while Asian ethnicity was more frequent.

Pregnancy outcomes

Maternal and neonatal outcomespergroup are presented in Table 2.Compared to the non-GDM group,women in group 3 were more likely to have a highest diastolic blood pressure ≥ 90 mmHg (18.6%vs13.9%,P= 0.007) and had similar rates of induction of labor,assisted vaginal deliveries and emergency caesarean section but were more likely to deliver by planned caesarean section (15.5%vs11.1%,P= 0.006).Indicated preterm birth occurred more often (1.2%vs0.3%,P= 0.024).Also,women in group 3 gave birth to children with higher median birth weight (3598vs3490 g,P<0.001),had higher rates of birth weight >4000 g (22.3%vs16.2%,P<0.001),LGA (16.2%vs10.2%,P<0.001) and higher rates of 5-min Apgar score <7 (3.9%vs2.0%,P= 0.01) compared to the offspring of women in the reference group 1 with normal glucose tolerance.SGA occurred less frequently in group 3 (5.4%vs8.0%,P<0.001).

In group 2,labor was more often induced (28.8%vs17.4%,P= 0.001) compared to the non-GDM group,as this is recommended in the Dutch guidelines for GDM.Rates of birth weight >4000 g,LGA and SGA were comparable between group 2 (15.0%,12.2% and 4.3%) and group 1 (allP>0.05).Other neonatal outcomes were also similar,except for shoulder dystocia,which occurred in 4.3% compared to 1.3% in group 1 (P= 0.015).

Women in group 4 were more likely to have a highest recorded diastolic blood pressure ≥ 90 mmHg,labor was induced more often and planned caesarean section rates were higher compared to the non-GDM group.Assisted vaginal deliveries were carried out less frequently in this group (3.6%vs6.4%,P= 0.018).Rates of both spontaneous and indicated preterm birth were also significantly higher (6.9%vs4.1%,P= 0.008 and 1.5%vs0.3%,P= 0.006 respectively) compared to group 1.Birth weight >4000 g and SGA did not differ between group 4 and the reference group 1.However,more infants were LGA (16.6%vs10.2%,P<0.001).Also,neonates were more likely to be admitted to the neonatology ward,and shoulder dystocia and a 5-min Apgar score <7 occurred more often.

Positive and negative likelihood ratios for adverse pregnancy outcomes with corresponding 95% confidence intervalspergroup are presented in Table 3.Compared to the non-GDM group,positive likelihood ratios (LR+) for adverse outcomes were generally higher in women with a positive OGTT according to either the WHO 1999,WHO 2013 or both criteria,except for assisted vaginal delivery and SGA.The LR+ for adverseoutcome,excluding assisted vaginal delivery and SGA,ranged from 0.76 to 2.95 for all groups.An OGTT indicative for GDM according to both criteria (group 4) had the highest LR+ for most adverse outcomes.A positive OGTT by the WHO 2013 criteria only (group 3) had higher LR+ for adverse outcomes compared to a positive OGTT by WHO 1999 criteria only (group 2).Negative likelihood ratios showed a similar but inverse pattern that were mostly close to 1.00.

Table 3 Likelihood ratios for adverse pregnancy outcomes for group 2-4 compared to group 1

LR+:Positive likelihood ratio;95%CI:95% confidence interval;LR-:Negative likelihood ratio;GDM:Gestational diabetes mellitus;BP:Blood pressure;SGA:Small-for-gestational-age;LGA:Large-for-gestational-age;WHO:World Health Organization;NICU:Neonatal intensive care unit.

DISCUSSION

In this study,we estimated the impact of adopting new criteria for GDM in a population where adherence to the traditional criteria is the current policy,with the aim to provide insight in the potential impact of modification of disease definitions for GDM.We showed that applying the WHO 2013 criteria would result in an absolute increase of GDM diagnoses in women at risk of 13.1% or a 1.7-fold increase in comparison to the current WHO 1999 criteria.The women newly identified by the WHO 2013 criteria showed less favorable patient characteristics,i.e.higher maternal age and BMI.Newly identified women also had an increased chance of adverse pregnancy outcomes,including higher blood pressure and higher rates of indicated preterm birth,LGA and 5-min Apgar score <7,compared to the women with a normal glucose tolerance after screening.Women only diagnosed by the 1999 criteria had similar patient characteristics and obstetric outcomes compared to those with a normal OGTT,although the latter may be because they underwent GDM treatment.

An increase in the number of GDM diagnoses,as we found in our study,is in line with the original Hyperglycemia and Adverse Pregnancy Outcome findings,which were the trigger to expand the GDM definition[10].However,effects of implementation of the WHO 2013 criteria show regional variation,depending on the population,screening approaches or the diagnostic criteria,which are in use prior to implementation[25-28,33,34].Studies performed in Asian populations have reported both a decrease and increase in the number of GDM diagnoses[35-37].The 1.7-fold increase in our cohort is similar to estimations from three previous European studies with similar risk-based screening strategies[16,19,38].Others have reported an even greater increase after actual implementation of the WHO 2013 criteria,such as a 3.5-fold increase in a study from Spain and a 4-fold increase in a Swiss cohort[39,40].In the United Arab Emirates,introduction of the new criteria would result in almost half of the pregnant population to be labelled as GDM[14].

In 2017 a multidisciplinary working group,which included members from the Guidelines International Network,Grading of Recommendations Assessment,Development and Evaluation working group and the WHO,proposed a checklist with issues that should be considered prior to introducing modified disease definitions[41].Although the checklist has not been formally applied to the GDM definition expansion proposed by the WHO (2013),several points on the checklist have yet to be met.For example,evaluation of incremental benefits for patients classified by the new and the previous definition is needed.Our study complements a previous cohort study from the Netherlands,which similarly found that the women newly identified by the WHO 2013 criteria are at increased risk for adverse pregnancy outcomes compared to pregnant women with normal glucose tolerance[19].Our analysis furthermore allowed us to directly compare the newly diagnosed group to those women in which the WHO 1999 criteria and WHO 2013 criteria agree,e.g.,expected ‘severe’ cases,and found that risks were generally lower in the newly added group.This is further strengthened by our analysis of likelihood ratios for adverse outcome for the different criteria.Positive likelihood ratios for adverse outcomes were lower in women with an abnormal OGTT by the WHO 2013 criteria compared to those positive by both criteria.However,an abnormal OGTT by any set of criteria showed only limited discriminative value in predicting adverse outcome,with the highest LR+ of 2.95 for shoulder dystocia and negative likelihood ratio mostly around 1.00.

Because the risk for adverse outcomes in the newly diagnosed women seems to be lower in comparison to the concordant group,it is this group of women facing possible overdiagnosis as a result of widening the diagnostic criteria for GDM.Multiple studies,all before-after studies,have shown positive effects on clinical outcomes,such as hypertensive disorders,LGA and caesarean section rates after implementation of the WHO 2013 criteria[39,42-44].However,given the concurrent increase in the number of women diagnosed,it is unclear whether these results are attributable to effective treatment or due to inclusion of milder GDM cases.In one study that adjusted for maternal characteristics,only limited reductions in adverse outcomes were observed[42].A randomized controlled trial found that treatment of milder GDM reduced LGA rates,shoulder dystocia,caesarean deliveries and hypertensive disorders[5].The inclusion criteria for this trial do not fully correspond to the patients newly diagnosed by the WHO 2013 criteria,limiting extrapolation of these treatment results.To this date,no data are available for women with discordant diagnosis for GDM between the WHO 1999 and 2013 criteria and with that the treatment effect in this group specifically remains unknown.However,clinical trials on this matter are currently being undertaken[6,45,46].

Another point raised in the checklist is evaluation of potential incremental harm to patients.We found in our cohort that the proportion of women with an OGTT discordant between WHO 1999 and WHO 2013 was larger than the proportion of women in which both criteria agree.Implementation of the WHO 2013 criteria would subsequently result in unevaluated treatment of more than half the GDM population.This treatment could result in unnecessary exposure to interventions with possible harmful side effects,including induction of labor and caesarean sections[8].Also,GDM diagnosis and subsequent medicalization can have profound negative effects on a patient’s quality of life[47-51].Similarly,underdiagnosis could occur in the group of women that are currently receiving treatment but would be excluded with the new criteria.Although this was a relatively small group in our cohort,evaluation is necessary to establish whether these women can be safely left untreated.

Other forms of incremental harm include increased costs and use of health care resources because of implementation of the new criteria[52].With estimated costs for GDM treatment in excess of standard antenatal care of €6843perindividual[53],implementation of the new criteria would result in a direct increase of medical costs of over 3 million euros for the study period in our center alone.In the Netherlands,approximately 5% of the pregnant population (approximately 8500 women) is diagnosed with GDM with the current criteria.A conservative 2% increase would result in 11900 diagnoses on a yearly basis,amounting up to over 23 million euros in additional health care costs.Data on cost-effectiveness are conflicting and are particularly influenced by the discriminative power of the new criteria to detect longer-term maternal,neonatal and infant outcome,which are currently largely unknown[39,54-56].

The strength of this study is the large sample size and availability of OGTT results,allowing for the reclassification in the four groups as presented in this study.This classification provides more insight on the impact of the WHO 2013 criteria by analyzing the women with discordant results separately,as proposed by the checklist on modifying disease definitions[41].However,because the WHO 1999 criteria were used to diagnose GDM in our cohort,a treatment effect is present in the women meeting these criteria.Furthermore,the reference group in this study consisted of women with normal OGTT results.Because women were either screened because of the presence of risk factors or clinical signs suggestive for GDM,this group is a selection and therefore not fully representative of the general obstetric population in the Netherlands.However,comparison of pregnancy outcomes with a reference group including women without any risk factors for GDM would probably only further strengthen the associations we found.Another limitation is that there were no 1-h post load OGTT measurements available in this cohort,which are used in the WHO 2013 criteria.This may have resulted in an underestimation of the proportion of women diagnosed with GDM upon implementation of the WHO 2013 criteria.

CONCLUSION

The results from this retrospective study indicate a marked increase in the number of women diagnosed with GDM with the adoption of the WHO 2013 criteria as compared to WHO 1999 criteria.We have shown that the new criteria identify a new group of women at risk for adverse pregnancy outcomes but also result in exclusion of a number of women that currently receive treatment.Randomized trials are urgently needed to establish whether treatment of women with mild hyperglycemia,formerly not labelled as GDM,indeed leads to improvement of perinatal outcome.Treatment effects should be assessed both on the short-term and on the long-term of both mother and child to establish benefits,harms and cost-effectiveness of adopting the new criteria prior to implementation.

ARTICLE HIGHLIGHTS

Research background

Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy.It is associated with both short- and long-term fetal,neonatal and maternal complications.Treatment of GDM has been shown to improve pregnancy outcomes.

Research motivation

Worldwide different diagnostic criteria to diagnose GDM are being used.Recently the Hyperglycemia and Adverse Pregnancy Outcome study has shown that maternal glucose levels below the most used thresholds increase the risk of adverse outcomes.As a result,new diagnostic criteria have been proposed by the World Health Organization (WHO) in 2013.These new,more stringent criteria have been shown to greatly affect the number of women diagnosed with GDM,which in turn can have great consequences for health care costs and effectiveness of current treatment strategies.However,the effects vary in different populations and are influenced by patient characteristics such as ethnicity and maternal body mass index.

Research objectives

We aimed to estimate the impact of the WHO 2013 criteria,compared with the WHO 1999 criteria,on the incidence of gestational diabetes mellitus as well as to determine the diagnostic accuracy for detecting adverse pregnancy outcomes.We sought to evaluate the patient characteristics and pregnancy outcomes of women with a discordant diagnosis specifically,as these are of importance for the treatment effects that may be expected.Currently,the treatment effects in these women are unknown.

Research methods

For this study we evaluated a cohort of 3338 women that were tested for GDM using a 75 g oral glucose tolerance test in the University Medical Center Utrecht.We applied both the current WHO 1999 criteria and the newly proposed WHO 2013 criteria for GDM.We determined the change in the number of GDM diagnoses.Also,we separately reported on patient characteristics and pregnancy outcomes of women with discordant diagnoses and compared these to the non-GDM women.Lastly,we determined the likelihood ratios for adverse outcomes for the different groups.

Research results

Retrospectively applying the WHO 2013 criteria increased the cohort incidence by 13.1%,from 19.3 to 32.4%.Discordant diagnoses occurred in 21.3%;4.1% would no longer be labelled as GDM,and 17.2% were newly diagnosed.Compared to the non-GDM group,women newly diagnosed were older,had higher rates of obesity,higher diastolic blood pressure and higher rates of caesarean deliveries.Their infants were more often delivered preterm,large-for-gestational-age and were at higher risk of a 5-min Apgar score <7.Women excluded from GDM were older and had similar pregnancy outcomes compared to the non-GDM group,except for higher rates of shoulder dystocia (4.3%vs1.3%,P= 0.015).Positive likelihood ratios for adverse outcomes in all groups were generally low,ranging from 0.54 to 2.95.

Research conclusions

The number of women diagnosed with GDM increases substantially with the WHO 2013 compared to the WHO 1999 criteria.Women additionally diagnosed are at increased risk for adverse pregnancy outcomes.However,they seem to be at lower risk than women who would be diagnosed with GDM by both the old and new criteria.Also,likelihood ratios for adverse outcomes comparing both diagnostic criteria are generally low.Treatment effects may therefore be lower in newly diagnosed women,which may result in overtreatment of women newly diagnosed with GDM according to the WHO 2013 criteria.

Research perspectives

Adopting the WHO 2013 criteria results in an increased number of women diagnosed with GDM and translates to an excess risk of adverse pregnancy outcomes,supporting the need for intervention studies to estimate the treatment benefit and cost-effectiveness to improve clinically relevant outcomes for these previously untreated pregnant women.