《实验动物与比较医学》2021年第41卷总目次

·创刊40周年专家论坛·

从人类基因组计划到精准医学——比较医学的发展趋势与挑战·········································· 赵国屏(1)

基于能力提升的我国实验动物资源发展愿景···································································· 贺争鸣(85)

脑缺血动物模型的制备及评估进展························································ 胡志斌，黄 缨，丁玉强(271)

复杂疾病小鼠模型构建新策略：类精子单倍体胚胎干细胞介导的半克隆技术··········································································································································· 赖梭梅，丁一夫，李劲松(369)

CNAS实验动物机构认可进展························································································ 吴孝槐(384)

利用中国仓鼠制备疾病模型的优势与进展······················ 高继萍，陈朝阳，轩瑞晶，张锐虎，宋国华(392)

·创刊40周年专题：各地实验动物科学发展·

西双版纳会议与湖北省实验动物科技发展40年历程·························································· 唐利军(9)

陕西省实验动物工作近10年发展历程····················································· 师长宏，刘恩岐，张 海(14)

黑龙江省实验动物管理现状与发展对策············································································································· 李宝龙，王玉娥，司昌德，李昌文，刘怀然，郭守利，韩凌霞，刘景利，李永明，陈洪岩(181)

山西省实验动物资源共享服务平台建设现状及发展对策············· 张锐虎，王春芳，宋国华，陈朝阳(190)

江苏省实验动物行政许可现状······································· 陈 林，艾 曼，徐 航，漆重阳，施爱民(284)

云南省实验动物工作40年发展历程与思考················································ 罕园园，李娜，代解杰(399)

·创刊40周年专题：期刊发展·

《实验动物与比较医学》创刊40年重要文献回顾······························································· 高 诚(17)

《实验动物与比较医学》创刊40年重点文献回顾（续）······················································· 高 诚(169)

·实验动物福利与伦理·

2020版美国兽医协会动物安乐死指南解析········································································································· 卢 今，张 颖，潘学营，王 剑，严国锋，周 晶，朱 莲，陈学进，李 垚，庞万勇(195)

小鼠生活笼实验引入适应期的必要性研究······················ 尹 媛，陆 璐，王 蕴，杨 景，付鹤玲(358)

·人类疾病动物模型·

慢性低氧性肺动脉高压大鼠动脉血气分析指标的变化及其意义····· 张舒婷，姚青青，李宜珊，施熠炜(27)

聚糖硫酸钠不同给药方式建立小鼠溃疡性结肠炎模型········ 赵亚妮，李 瑶，张 妍，王四旺，安军明(33)

雌性侏儒症大鼠繁殖性能初探···················································· 焦淑凡，徐龙妹，华征宇，姚菊芳(40)

高脂饲料诱导代谢性疾病动物模型·········· 罗建波，李军晖，王海江，周小玉，曾 涛，周 佳，朱献军(70)

免疫功能正常的HBV cccDNA小鼠模型用于苦参碱和青蒿素抑制HBV的药效评价··············································· 伍 悦，吕小琴，刘 阳，向 霞，赵中华，徐如青，潘朔寒，何明忠，张华堂，赖国旗(108)

皮肤光老化小鼠模型的构建及效果评估····························································· 孔 悦，郭 砚(116)

肝螺杆菌感染促进高脂饲料诱导的小鼠非酒精性脂肪性肝病进展·································································································································· 沈 宸，吴志浩，殷 俊，朱立麒，张 泉(122)

1型糖尿病早期大鼠空肠的神经功能及组织形态学变化····································································································································· 王 嫚，祗明花，耿旭芳，佟苗苗，梁红玉，赵 丁(131)

五苓散对高脂血症模型贵州小型猪的治疗作用·························································································································· 张 慧，吴延军，姚 瑾，陆涛峰，王郭琦，赵 海，姚 刚，吴曙光(138)

一种大鼠跑台抗阻训练模型的构建························································ 蔺海旗，王 震，林文弢(143)

松果体损伤大鼠模型3种制备方法的比较研究···························· 王丹妮，宋美卿，杨 钤，冯玛莉(215)

人脑胶质瘤大鼠移植模型的初步建立···························· 谭邓旭，吴朋朋，赵 勇，师长宏，葛 煦(220)

肝螺杆菌感染对葡聚糖硫酸钠诱导小鼠慢性结肠炎模型的影响······································································································································ 吴志浩，沈 宸，殷 俊，朱立麒，张 泉(226)

慢性间歇性低氧模型大鼠的甲状腺功能分析·········································· 田 慧，高 隆，王泽辉(232)

高原多脏器功能障碍综合征蕨麻猪模型C反应蛋白及炎性因子的变化···································································································· 肖 攀，牛廷献，罗晓红，王红义，郭晓宇，陆 璐，冯小明(238)

小鼠脊髓损伤打击模型精细行为的比较研究······ 颜义彤，白 帆，荆瀛黎，王立淼，李子晗，于 艳(290)

肉芽肿小叶性乳腺炎大鼠模型建立初探····································································································································· 左禧萌，史晓光，刘洁丽，杨臻瑞，高 翔，赖 瑞，赵 泽，汪唐顺(299)

槲皮素对镉致小鼠肝脏脂质代谢紊乱模型的保护效应··························································································································· 李自发，张 浩，任 萌，徐凯勇，胡明会，周苗苗，王可洲(305)

二甲双胍对阿尔茨海默症模型大鼠认知功能障碍及PI3K/Akt通路的影响···························································································································· 王百乔，林小茹，韩敏，刘 煜，唐超玲(313)

β-氨基丙腈联合血管紧张素Ⅱ改良法建立小鼠主动脉夹层模型·································································································· 程玲霞，陈 琳，杨 帆，刘 英，陈睦虎，胡迎春，宋其泰，钟 武(321)

高渗盐水保护血脑屏障减轻脑出血大鼠脑水肿的相关机制研究··········· 第五飞虎，赵志靖，邓毅恒(327)

MC38结肠癌小鼠肿瘤浸润免疫细胞的动态变化············ 张波扬，陈焕鹏，余文兰，刘忠华，黄朝峰(409)

CD137信号调控内皮细胞间质转化促进小鼠心脑血管新生·········· 翁嘉懿，马雪兴，李 渊，孙康云(418)

咽立爽口含滴丸对慢性咽炎家兔免疫细胞亚群及NF-κB信号通路的影响······················································································································· 唐 燚，喻国冻，何星辰，王 佳，张 田(426)

多囊卵巢综合征-胰岛素抵抗大鼠子宫组织中PPARs异常表达与胰岛素抵抗的关系································································································ 魏 巍，陈艺华，张秀智，冷义福，李 纯，尹天晓(435)

基于糖尿病-肿瘤小鼠模型研究糖尿病对结直肠癌/乳腺癌进展及肠道菌群的影响························································································································· 王晓钰,蒋升瑶,蔺智兵,崔 立(469)

小鼠腹主动脉瘤模型的建立及组织学特征分析······································································································································ 夏聪聪,刘浩乐,魏盼盼,成大欣,胥宝会,刘恩岐,赵四海(480)

四氯化碳诱导急性肝损伤大鼠模型对心脏的影响···································································································································· 张丽丽,万 鑫,冀菁荃,李 婷,范毅敏,李宝红,田帅燕(486)

人源肿瘤异种移植动物模型在癌症精准医学研究中的应用······················ 宋伟杰,周 岩,牛瑞芳(493)

Rncat先天性白内障小鼠模型培育及初步应用····················································· 张 燕,燕顺生(501)

卵巢早衰动物模型构建方法及比较研究进展······················································································································································· 李虹璇,李思慧,冯嘉欣,唐 凯,卢 蕊,韩丝银(505)

糖尿病动物皮肤损伤模型制备要素和受试物数据的文献分析······················································································································ 林江,骆 飞,刘 鹏,韩丝银,陈振兴,梁忠秀,兰太进(515)

·技术与方法·

利用基质胶阻断门静脉建立改良ALPPS手术小鼠模型·················· 沈 皓，陈 瑶，沈 锋，吴孟超(91)

大鼠尾椎间盘不同切片方式及染色方法的组织学观察比较······················ 赵宇朋，周平辉，官建中(100)

大鼠血清葡萄糖测定分析的影响因素········································································································································ 李 红，敬海明，林长缨，郭 婧，张 勐，张 超，高 珊，余儒洋(466)

2013—2020年7次实验动物病原菌项目国际比对结果分析·············································································································· 邢 进，冯育芳，王 洪，张雪青，高 强，岳秉飞，付 瑞(521)

基于团体标准T/CALAS 21—2017的Wistar大鼠微卫星DNA群体遗传质量分析························································ 魏 杰，左 琴，王 洪，李 欢，周佳琪，光姣娜，范 涛，刘佐民，付 瑞，岳秉飞(528)

影响细菌人工染色体转基因小鼠制备效率的因素分析······· 王芊芊，王 伟，刘 睿，刘 振，刘 冲(535)

大鼠气管滴注方法的改良及效果评价······························ 余伊翔，曹珊珊，冯 怡，李嘉瑞，王 荣(543)

可视化核酸检测技术RPA-LFD的研究和应用进展·································· 于灵芝，陶凌云，魏晓锋(547)

·实验动物管理·

实验材料检测在SPF级实验小鼠质量控制中的应用····················································································································· 陈国元，康 康，李晓娴，纪文韬，张金梅，冯延花，田倩莹，吴宝金(61)

实验动物健康码管理的架构设计····································· 姜 鲲，汤逸雯，刘延滨，陈历銘，汤宏斌(66)

人工繁育恒河猴的肺炎链球菌携带状况调查及分析················································· 刘 雨，李艳艳，张 伟，杨凤梅，刘 权，李咏洁，靳玮华，段素琴，王俊斌，陈丽雄，徐鸿界，赵 远，和占龙(259)

小鼠诺如病毒感染实验小鼠的抗体变化规律分析··········································································································· 李晓波，付 瑞，王淑菁，李 威，王莎莎，黄宗文，秦 骁，王 吉，岳秉飞(343)

小鼠嗜肺巴斯德杆菌检测方法优化及感染小鼠的药物净化·········· 张 韬，崔 璨，马贯中，张爱华(351)

病原微生物防控在实验动物设施管理与生物安全控制中的作用探讨······························································································································· 罗银珠，闵凡贵，王 静，何丽芳，潘金春(443)

医学院校实验动物及实验室安全培训的实践探索··············· 宋国英，许燕，朱美霖，张宏伟，李 沛(450)

医学实验教学动物尸体二维码信息管理系统建立的设想···· 金 悠，王晨晨，余上斌，罗隽宇，周顺长(455)

高校实验动物集中采购系统的建设与应用实践：以首都医科大学为例········································································································································· 刘晓楠，张 伟，孟 霞，卢 静(459)

高校实验动物管理流程信息化探索：以浙江大学为例······························· 陈晓娟,李 巍,汪 洌(554)

·实验动物与精神医学·

从脑胃ghrelin通路探讨应激对大鼠食欲的影响···· 赵怡玲，高鹏飞，肖 茜，张 岚，潘丹青，徐月妹(207)

·实验动物与中医药·

痰热清注射液的安全药理学动物实验评价······················································································································ 胡 俊，张小利，杨 春，陆锦遥，王 琼，谷颖敏，谢家骏，张超超，田雪松(46)

竹节香附素A对肝缺血再灌注大鼠的保护作用机制······················ 李洪波，黄 锐，代 将，钟振东(55)

苦参素对实验性自身免疫性甲状腺炎大鼠Th1/Th2细胞平衡及相关通路的影响······································································································································· 姚 婷，高 原，曾芳馨(244)

·实验动物与安全性评价·

耐辐射奇球菌R1对大鼠的慢性毒性实验·············································································································· 许 琴，王 玮，董翔，李建瑛，是文辉，刘晓禄，刘爱中，马 娜，宋来阳，刘江伟(333)

·实验动物资源·

树鼩脊髓微血管内皮细胞的分离培养及EV71感染实验···· 施梅言，王 璇，王文广，阮蕾颖，代解杰(148)

几种常用免疫缺陷小鼠的血液学及血液淋巴细胞亚群的测定与比较分析·······································谈小倩，瞿 伟，李 亮，钱 珍，顾坚忠，徐 平····································································· (155)

小鼠树突状细胞亚群分类及其比较研究进展···················································· 阮蕾颖，孙晓梅(174)

·实验动物设施·

溶液式环境控制设备在实验动物设施中的应用··············· 张 婷，陈亮亮，李海翔，黄发洲，蔡武凯(161)

两种不同类型实验动物屏障设施的气流组织计算流体力学模拟技术分析···································································································································· 周 斌，赵 勇，汪亚兵，刘吉宏(252)

·教育培训实践·

医院科研工作中开展实验动物福利伦理教育的探索································ 余 飞，钱丽萍，沙莉莉(166)

基于互联网交互平台三明治教学法在医学实验动物学教学中的应用··················································································································· 魏 盛，耿希文，徐凯勇，胡明会，周苗苗，李自发(266)

·实验动物产业与信息服务·

实验动物电商平台数据分析与对策建议················································· 温金银，陈 焰，李会萍(363)

·规范与指南·

学术研究实施与报告和医学期刊编辑与发表的推荐规范（三）····················································································································· 国际医学期刊编辑委员会(张俊彦，于笑天，汪 源，译)(79)