遗传 2020年 第42卷 总目次

遗传 2020年 第42卷 总目次

第1期

三维基因组专栏

染色质构象与基因功能……………………………………………………………………黄其通，李清，张玉波(1)

CRISPR/Cas9基因编辑在三维基因组研究中的应用……………………………………………………………………刘沛峰，吴强(18)

细胞终末分化过程中三维基因组结构与功能调控的分子机制……………………………………………………………………杨科，薛征，吕湘(32)

生物大分子“液–液相分离”调控染色质三维空间结构和功能……………………………………………………………………高晓萌，张治华(45)

Cohesin结构及功能研究进展……………………………………………………………………张雨，方玉达(57)

植物三维染色质构型研究进展……………………………………………………………………董芊里，王金宾，李晓宠，宫磊(73)

基于生物信息学的Hi-C研究现状与发展趋势……………………………………………………………………吕红强，郝乐乐，刘二虎，吴志芳，韩九强，刘源(87)

研究报告

DNMT3a通过提升基因内部甲基化介导紫杉醇诱导的LINE-1异常表达……………………………………………………………………王昕源，张雨，杨楠，程禾，孙玉洁(100)

内侧前额叶皮质DNA甲基化调控大鼠酒精相关行为……………………………………………………………………崔亨贞，孙蜜烛，王润芝，李辰雨，黄予暄，黄秋菊，乔晓孟(112)

综合信息

致谢2019年度审稿编委和审稿专家……………………………………………………………………(126)

第2期

综 述

超家族转座子研究进展……………………………………………………………………从春生，李玉斌(131)

基因组选择在猪杂交育种中的应用……………………………………………………………………杨岸奇，陈斌，冉茂良，杨广民，曾诚(145)

RNAi在抗蚊媒病毒感染中的研究进展……………………………………………………………………魏勇，何玉兰，郑学礼(153)

研究报告

突变导致先天性白内障及其在晶状体中的表达……………………………………………………………………于雅洁，邱峰，张新安(161)

脱发相关差异表达基因的生物信息学分析……………………………………………………………………向虹，阳小胡，艾亮霞，潘燕平，胡勇(172)

七鳃鳗分子鉴定、重组表达及免疫学研究……………………………………………………………………李歆，渠成名，韩英伦，刘欣，李庆伟(183)

互花米草NAC转录因子家族的鉴定与表达分析……………………………………………………………………王涛涛，杨勇，魏唯，林辰涛，马留银(194)

资源与平台

2019新型冠状病毒信息库……………………………………………………………………赵文明，宋述慧，陈梅丽，邹东，马利娜，马英克，李茹姣，郝丽丽，李翠萍，田东梅，唐碧霞，王彦青，朱军伟，陈焕新，章张，薛勇彪，鲍一明(212)

遗传学教学

通识教育中融入人类遗传学的教学实践……………………………………………………………………程汉华，周荣家(222)

综合信息

作者须知……………………………………………………………………(230)

第3期

前沿聚焦

STEME系统：一种助力体内定向进化的新工具……………………………………………………………………胡风越，王克剑(231)

综 述

CRISPR-Cas基因编辑系统升级：聚焦Cas蛋白和PAM……………………………………………………………………唐连超，谷峰(236)

单细胞测序技术及其在乳腺癌研究中的应用……………………………………………………………………张强，顾明亮(250)

单细胞RNA测序技术在病毒研究中的应用……………………………………………………………………屈亮，李素，仇华吉(269)

寄主植物与病原菌免疫反应的分子遗传基础……………………………………………………………………杨德卫，李生平，崔海涛，邹声浩，王伟(278)

研究报告

PAI-1过表达促进食管鳞癌细胞的侵袭和迁移……………………………………………………………………王迪，杨荔艳，刘奏，余竟，张敏杰，张钰，蔡岩，徐昕，郝佳洁，王明荣(287)

74-plex SNPs复合检测体系在中国人群中的族群推断研究……………………………………………………………………刘杨，孙昌春，马咪，王玲，赵雯婷，马泉，季安全，刘京，李彩霞(296)

家兔前体脂肪细胞分化不同时期基因表达谱分析……………………………………………………………………杜坤，毛初阳，任安勇，吴雪梅，李庆玲，陈婷婷，陈仕毅，赖松家(309)

多组学关联分析揭示表观等位基因在拟南芥环境适应性进化中的作用及机制……………………………………………………………………梅志超，位竹君，于佳慧，冀凤丹，解莉楠(321)

综合信息

作者须知……………………………………………………………………(332)

第4期

综 述

染色质转座酶可及性测序研究进展……………………………………………………………………吴杰，全建平，叶勇，吴珍芳，杨杰，杨明，郑恩琴(333)

ATAC-seq在复杂疾病研究中的应用进展……………………………………………………………………陈敏，张峥，孟紫媛，张学军(347)

NMD逃逸机制及其在疾病治疗中的应用……………………………………………………………………程苗苗，曹延延(354)

数字PCR技术及其在检测领域的应用……………………………………………………………………冯秀晶，易红梅，任星旭，任佳丽，葛建镕，王凤格(363)

研究报告

中国人群中抗结核药物引发肝损伤的易感基因标记研究……………………………………………………………………周晨希，李沫，怀聪，贺林，秦胜营(374)

双基因转染山羊乳腺上皮细胞表达分析……………………………………………………………………宋绍征，于康英，张婷，陆睿，潘生强，周鸣鸣，成勇(380)

乏情和发情初产母猪下丘脑–垂体–卵巢轴中lincRNAs表达谱比较分析……………………………………………………………………任巧玲，张家庆，陆东锋，王璟，陈俊峰，马强，白献晓，郭红霞，高彬文，邢宝松(388)

小拟南芥MKK基因家族全基因组鉴定及进化和表达分析……………………………………………………………………李晓翠，康凯程，黄先忠，范永斌，宋苗苗，黄韵杰，丁佳佳(403)

综合信息

作者须知……………………………………………………………………(422)

第5期

综 述

环状RNA翻译能力研究进展……………………………………………………………………郑帅龙，李利，张红平(423)

基于CRISPR/Cas9系统在全基因组范围内筛选功能基因及调控元件研究进展……………………………………………………………………刘思远，易国强，唐中林，陈斌(435)

Schlafen家族蛋白在肿瘤和病毒感染中的研究进展……………………………………………………………………陈淑敏，马铃，岑山(444)

代谢组学技术发展及其在农业动植物研究中的应用……………………………………………………………………田菁，王宇哲，闫世雄，孙帅，贾俊静，胡晓湘(452)

植物单倍体诱导技术发展与创新……………………………………………………………………陈海强，刘会云，王轲，张双喜，叶兴国(466)

研究报告

2型糖尿病易感基因SNP位点对生活方式干预降低血糖应答效果的修饰效应……………………………………………………………………王玉琢，张一鸣，董晓莲，王学才，朱建福，王娜，江峰，陈跃，姜庆五，付朝伟(483)

利用SNP芯片信息评估新疆近交牛基因组纯合度……………………………………………………………………师睿，张毅，王雅春，黄涛，卢国昌，岳涛，卢振西，黄锡霞，卫新璞，冯书堂，陈军，乌兰·卡格德尔，茹先古丽·阿不力孜，努尔胡马尔·木合塔尔(493)

水稻典型品种日本晴和IR24根系微生物组的解析……………………………………………………………………胡雅丽，戴睿，刘永鑫，张婧赢，胡斌，储成才，袁怀波，白洋(506)

第6期

前沿聚焦

Prime editing引导植物基因组精确编辑新局面……………………………………………………………………秦瑞英，魏鹏程(519)

综 述

精子尾部发育相关蛋白研究进展……………………………………………………………………钟亚楠，牛长敏，夏蒙蒙，郑英(524)

组蛋白去乙酰化酶在调节心肌肥大过程中的作用机制……………………………………………………………………任恋，吴秀山，李永青(536)

泛素化途径在奶牛乳脂生成过程中的调控作用……………………………………………………………………刘莉莉，郭爱伟，李青青，吴培福，杨亚晋，陈粉粉，李素华，郭盘江，张勤(548)

CRISPR/Cas核糖核蛋白介导的植物基因组编辑……………………………………………………………………李霞，施皖，耿立召，许建平(556)

研究报告

中国西南地区藏族人群遗传亚结构研究……………………………………………………………………王小娟，钱恩芳，李悦，宋正阳，赵慧，谢何鑫，李彩霞，黄江，江丽(565)

基于结直肠癌细胞系MIC50相关基因对的基础耐药评分模型构建……………………………………………………………………陈湖星，徐蕾，李静，郭政，敖露(577)

利用Trim-Away技术降低人胰岛淀粉样多肽在大鼠胰岛素瘤细胞中的毒性……………………………………………………………………龚葭薇，孔德麟，杨琳，聂玉哲，梁洋，滕春波(586)

技术与方法

基于体细胞突变数据库筛选免疫原性结直肠癌高频新抗原的方法……………………………………………………………………秦丽丽，李毅坚，梁兆端，陈蕾，李文慧，陈超，黄亚灵，张乐，刘松明，邱思，葛玉萍，彭文婷，林欣欣，张秀清，董旋，李波(599)

第7期

特邀综述

翻译延伸的顺式调控机理与生物学效应……………………………………………………………………肇涛澜，张硕，钱文峰(613)

综 述

DNA羟甲基化调控动脉粥样硬化的研究进展……………………………………………………………………胡颖楚，胡豪畅，林少沂，陈晓敏(632)

提高CRISPR/Cas9介导的动物基因组精确插入效率研究进展……………………………………………………………………李国玲，杨善欣，吴珍芳，张献伟(641)

CRISPR/Cas9系统在林木基因编辑中的应用……………………………………………………………………陈赢男，陆静(657)

研究报告

SLFN14抗LINE-1分子机制研究……………………………………………………………………毛洋，丁寄葳，陈淑敏，岑山，李晓宇(669)

中国汉族人群脸部特征相关SNP位点研究……………………………………………………………………刘明，李祎，杨亚芳，晏于文，刘凡，李彩霞，曾发明，赵雯婷(680)

基于序列相似性和Z曲线方法重注释原核生物蛋白编码基因……………………………………………………………………刘硕，曾志，曾凡才，杜萌泽(691)

技术与方法

基于单细胞靶向测序探究基因碱基突变的方法……………………………………………………………………赵利楠，王娜，杨国良，苏现斌，韩泽广(703)

第8期

综 述

G蛋白偶联受体相关分选蛋白功能特征与相关疾病研究进展……………………………………………………………………张敏，梁丽鸿，鲁雅洁，曹新(713)

斑马鱼血液疾病模型及应用……………………………………………………………………郭佳妮，刘帆，王璐(725)

激素调控植物成花机理研究进展……………………………………………………………………邹礼平，潘铖，王梦馨，崔林，韩宝瑜(739)

假单胞菌噬菌体基因组学研究进展……………………………………………………………………徐志伟，魏云林，季秀玲(752)

研究报告

RFX5调控原钙粘蛋白基因簇的表达……………………………………………………………………王娜，甲芝莲，吴强(760)

DNA甲基化驱动的转录表达特征作为肝癌预后预测标志物的价值……………………………………………………………………骆红波，曹鹏博，周钢桥(775)

大豆E2泛素结合酶基因的克隆及在拟南芥中的异源表达……………………………………………………………………毛卓卓，宫宇，史贵霞，李亚丽，喻德跃，黄方(788)

资源与平台

CNGBdb：国家基因库生命大数据平台……………………………………………………………………陈凤珍，游丽金，杨帆王丽娜，郭学芹，高飞，华聪，谈聪，方林，单日强，曾文君，王博，王韧，徐讯，魏晓锋(799)

遗传学教学

形成性评价与教学反馈在医学遗传学PBL教学中的应用……………………………………………………………………王涛，梁亮，郑敏化(810)

第9期

综 述

增强子的鉴定及其在肿瘤研究中的应用……………………………………………………………………刘倩，李春燕(817)

慢性阻塞性肺疾病全基因组关联研究进展……………………………………………………………………钱国清(832)

七鳃鳗：生物进化和疾病研究的重要模式动物……………………………………………………………………朱医高，李军，逄越，李庆伟(847)

植物激素水杨酸生物合成和信号转导研究进展……………………………………………………………………谷晓勇，刘扬，刘利静(858)

用于临床新型冠状病毒核酸检测的分子诊断新技术……………………………………………………………………谢春梅，武海萍，马雪萍，周国华(870)

研究报告

端粒长度与2型糖尿病：孟德尔随机化研究与多基因风险评分分析……………………………………………………………………曹岚，李志强，师咏勇，刘赟(882)

骨质疏松易感SNP rs4325274通过增强子远程调控基因的功能机制研究……………………………………………………………………妥晓梅，朱东丽，陈晓峰，荣誉，郭燕，杨铁林(889)

猪耳成纤维细胞转录组异质性及对核移植胚胎发育的潜在影响……………………………………………………………………周俊，赵成成，吴霄，石俊松，周荣，吴珍芳，李紫聪(898)

遗传学教学

普通小麦相关研究进展在遗传学理论教学中的应用……………………………………………………………………赵娜，亓宝，董芊里，王晓丽(916)

第10期

编委推荐(927)

综 述

真核生物起源研究进展……………………………………………………………………高志伟，王龙(929)

基于CRISPR/Cas9技术的β-地中海贫血和血友病基因治疗研究进展……………………………………………………………………鲍莉雯，周一叶，曾凡一(949)

PCSK9降解低密度脂蛋白受体分子机制研究进展……………………………………………………………………吴玉娴，王琰(965)

动物骨代谢相关信号通路研究进展……………………………………………………………………赵净颖，段小花，王秋婷，黄英，贾俊静，豆腾飞(979)

体细胞克隆猪发育异常研究进展……………………………………………………………………敖政，陈祥，吴珍芳，李紫聪(993)

研究报告

早期停育胚胎的滋养层细胞相关基因与特征分析……………………………………………………………………张悦，冯颖，马芳(1004)

利用CRISPR/Cas9 AAV系统构建纹状体基因敲除小鼠模型……………………………………………………………………林珉婷，赖璐璐，赵淼，林必玮，姚香平(1017)

技术与方法

基于核质遗传原理建立多重PCR检测方法鉴定阿胶中马、驴源性成分及皮张种源……………………………………………………………………谌阳，王文君，付明，徐国强，周翔，刘榜(1028)

第11期

编委推荐(1037)

热点追踪

抑制胆固醇合成促进能量消耗并改善代谢综合征……………………………………………………………………王琰(1039)

综 述

诱导多能干细胞技术及其在疾病研究中的应用……………………………………………………………………蔡晨依，孟飞龙，饶琳，刘云玥，赵小立(1042)

miRNA与肾脏发育……………………………………………………………………赵晓琪，敖英，陈海云，汪晖(1062)

农业动物干细胞研究进展……………………………………………………………………王冰源，牟玉莲，李奎，刘志国(1073)

犏牛雄性不育的减数分裂基因表达与表观遗传调控研究进展……………………………………………………………………陈会友，张建敏，李柏森，邓永琳，张龚炜(1081)

双翅目昆虫基因组研究进展……………………………………………………………………彭威，冯蒙洁，陈皓，韩宝瑜(1093)

研究报告

细胞凋亡反应中基因启动子发挥增强子功能调节基因表达……………………………………………………………………秦中勇，石晓，曹平平，褚鹰，管蔚，杨楠，程禾，孙玉洁(1110)

基因在果蝇睾丸生殖细胞中的功能分析……………………………………………………………………陈万银，颜一丹，栾晓瑾，王敏，方杰(1122)

遗传学教学

对分课堂下本科生医学遗传学自主学习能力的培养……………………………………………………………………杨榆玲，罗兰，钱源，杨芳(1133)

综合信息

2020年《遗传》新一届编委会第一次会议圆满结束……………………………………………………………………(1140)

第12期

编委推荐……………………………………………………………………(1141)

综 述

MNase-seq与核小体定占位研究……………………………………………………………………邓玮杭，李鑫辉(1143)

m6A修饰对中枢神经系统功能及疾病的影响……………………………………………………………………史佳宾，王大勇，夏晴，高旭(1156)

精准调控CRISPR/Cas9基因编辑技术研究进展……………………………………………………………………曹俊霞，王友亮，王征旭(1168)

circRNA及其调控动物骨骼肌发育研究进展……………………………………………………………………郑婷，甘麦邻，沈林園，牛丽莉，郭宗义，王金勇，张顺华，朱砺(1178)

研究报告

纳米银颗粒及纳米二氧化钛颗粒的体外遗传毒性研究……………………………………………………………………朱海美，黄鹏程，赵田田，周长慧，李若婉，于春荣，陈志勇，顾林峰，常艳(1192)

RNA结合蛋白Roquin负调控STING依赖的果蝇天然免疫反应……………………………………………………………………杜倍倍，刘磊，朱洋洋(1201)

遗传学教学

遗传漂变教学方法刍议……………………………………………………………………王春明，林昌俊，冯虎元(1211)

科研进展

CRISPR-Cas9对人类线粒体基因组微同源区切割后产生新生变异……………………………………………………………………王邦，谷峰(1221)

HEREDITAS (Beijing)

YICHUAN

2020 Vol. 42

CONTENTS

No. 1

Special Section: 3D Genome

Linking chromatin conformation to gene function……………………………………………………………………Qitong Huang, Qing Li, Yubo Zhang(1)

Probing 3D genome by CRISPR/Cas9……………………………………………………………………Peifeng Liu, Qiang Wu(18)

Molecular mechanism of the 3D genome structure and function regulation during cell terminal differentiation……………………………………………………………………Ke Yang, Zheng Xue, Xiang Lv(32)

Three-dimensional structure and function of chromatin regulated by “liquid-liquid phase separation” of biological macromolecules.……………………………………………………………………Xiaomeng Gao, Zhihua Zhang(45)

Progresses on the structure and function of cohesin……………………………………………………………………Yu Zhang, Yuda Fang(57)

Progresses in the plant 3D chromatin architecture……………………………………………………………………Qianli Dong, Jinbin Wang, Xiaochong Li, Lei Gong(73)

Current status and future perspectives in bioinformatical analysis of Hi-C data……………………………………………………………………Hongqiang Lyu, Lele Hao, Erhu Liu, Zhifang Wu, Jiuqiang Han, Yuan Liu(87)

Research Article

DNMT3a mediates paclitaxel-induced abnormal expression of LINE-1 by increasing the intragenic methylation…………………………………………………………………………………………………………………………………………Xinyuan Wang, Yu Zhang, Nan Yang, He Cheng, Yujie Sun(100)

DNA methylation in the medial prefrontal cortex regulates alcohol-related behavior in rats……………………………………………………………………Hengzhen Cui, Mizhu Sun, Runzhi Wang, Chenyu Li, Yuxuan Huang, Qiuju Huang, Xiaomeng Qiao(112)

No. 2

Review

Progress onsuperfamily……………………………………………………………………Chunsheng Cong, Yubin Li(131)

The application of genomic selection in pig cross breeding……………………………………………………………………Anqi Yang, Bin Chen, Maoliang Ran, Guangmin Yang, Cheng Zeng(145)

Research progress in RNA interference against the infection of mosquito-borne viruses……………………………………………………………………Yong Wei, Yulan He, Xueli Zheng(153)

Research Article

Studies of congenital cataract-relatedmutation and its expression in the lens……………………………………………………………………Yajie Yu, Feng Qiu, Xin-an Zhang(161)

Bioinformatics analysis of differentially expressed genes on alopecia……………………………………………………………………Hong Xiang, Xiaohu Yang, Liangxia Ai, Yanping Pan, Yong Hu(172)

Identification, recombinant expression and immunological study ofin Lampetra japonica……………………………………………………………………Xin Li, Chengming Qu, Yinglun Han, Xin Liu, Qingwei Li(183)

Identification and expression analyses of the NAC transcription factor family in……………………………………………………………………Taotao Wang, Yong Yang, Wei Wei, Chentao Lin, Liuyin Ma(194)

Resource and Platform

The 2019 novel coronavirus resource……………………………………………………………………Wenming Zhao, Shuhui Song, Meili Chen, Dong Zou, Lina Ma, Yingke Ma, Rujiao Li, Lili Hao, Cuiping Li, Dongmei Tian, Bixia Tang, Yanqing Wang, Junwei Zhu, Huanxin Chen, Zhang Zhang, Yongbiao Xue, Yiming Bao(212)

Genetics Teaching

Teaching practice in human genetics integrated into general education……………………………………………………………………Hanhua Cheng, Rongjia Zhou(222)

No. 3

Frontier Focus

The STEME system: a novel tool for directed evolution……………………………………………………………………Fengyue Hu, Kejian Wang(231)

Review

Next-generation CRISPR-Cas for genome editing: focusing on the Cas protein and PAM……………………………………………………………………Lianchao Tang, Feng Gu(236)

Single-cell sequencing and its application in breast cancer……………………………………………………………………Qiang Zhang, Mingliang Gu(250)

Applications of single-cell RNA sequencing in virology……………………………………………………………………Liang Qu, Su Li, Huaji Qiu(269)

Molecular genetic mechanisms of interaction between host plants and pathogens……………………………………………………………………Dewei Yang, Shengping Li, Haitao Cui, Shenghao Zou, Wei Wang(278)

Research Article

PAI-1 overexpression promotes invasion and migration of esophageal squamous carcinoma cells……………………………………………………………………Di Wang, Liyan Yang, Zou Liu, Jing Yu, Minjie Zhang, Yu Zhang, Yan Cai, Xin Xu, Jiajie Hao, Mingrong Wang(287)

The ancestry inference of Chinese populations using 74-plex SNPs system……………………………………………………………………Yang Liu, Changchun Sun, Mi Ma, Ling Wang, Wenting Zhao, Quan Ma, Anquan Ji, Jing Liu, Caixia Li(296)

Analysis of gene expression profiles at different stages during preadipocyte differentiation in rabbits……………………………………………………………………Kun Du, Chuyang Mao, Anyong Ren, Xuemei Wu, Qingling Li, Tingting Chen, Shiyi Chen, Songjia Lai(309)

Multi-omics association analysis revealed the role and mechanism of epialleles in environmental adaptive evolution of……………………………………………………………………Zhichao Mei, Zhujun Wei, Jiahui Yu, Fengdan Ji, Linan Xie(321)

No. 4

Review

Advances in assay for transposase-accessible chromatin with high-throughput sequencing……………………………………………………………………Jie Wu, Jianping Quan, Yong Ye, ZhenFang Wu, Jie Yang, Ming Yang, Enqin Zheng(333)

ATAC-seq and its applications in complex disease……………………………………………………………………Min Chen, Zheng Zhang, Ziyuan Meng, Xuejun Zhang(347)

The NMD escape mechanism and its application in disease therapy……………………………………………………………………Miaomiao Cheng, Yanyan Cao(354)

Digital PCR and its application in biological detection……………………………………………………………………Xiujing Feng, Hongmei Yi, Xingxu Ren, Jiali Ren, Jianrong Ge, Fengge Wang(363)

Research Article

Study on hereditary susceptibility genetic markers to anti-tuberculosis drug induced liver injury in Chinese population……………………………………………………………………Chenxi Zhou, Mo Li, Cong Huai, Lin He, Shengying Qin(374)

Expression analysis ofdouble genes in transfected goat mammary epithelial cells……………………………………………………………………Shaozheng Song, Kangying Yu, Ting Zhang, Rui Lu, Shengqiang Pan, Mingming Zhou, Yong Cheng(380)

Comparison and analysis of lincRNAs expression profile in the hypothalamic-pituitary-ovarian axis of anestrous and estrous primiparous sows……………………………………………………………………Qiaoling Ren, Jiaqing Zhang, Dongfeng Lu, Jing Wang, Junfeng Chen, Qiang Ma, Xianxiao Bai, Hongxiao Guo, Binwen Gao, Baosong Xing(388)

Genome-wide identification, phylogenetic analysis and expression profiling of the MKK gene family in……………………………………………………………………Xiaocui Li, Kaicheng Kang, Xianzhong Huang, Yongbin Fan, Miaomiao Song, Yunjie Huang, Jiajia Ding(403)

No. 5

Review

Progress on translation ability of circular RNA……………………………………………………………………Shuailong Zheng, Li Li, Hongping Zhang(423)

Progress on genome-wide CRISPR/Cas9 screening for functional genes and regulatory elements……………………………………………………………………Siyuan Liu, Guoqiang Yi, Zhonglin Tang, Bin Chen(435)

Progress of SLFN family proteins in tumor and virus infection……………………………………………………………………Shumin Chen, Ling Ma, Shan Cen(444)

Metabolomics technology and its applications in agricultural animal and plant research……………………………………………………………………Jing Tian, Yuzhe Wang, Shixiong Yan, Shuai Sun, Junjing Jia, Xiaoxiang Hu(452)

Development and innovation of haploid induction technologies in plants……………………………………………………………………Haiqiang Chen, Huiyun Liu, Ke Wang, Shuangxi Zhang, Xingguo Ye(466)

Research Article

Modification effects of T2DM-susceptible SNPs on the reduction of blood glucose in response to lifestyle interventions……………………………………………………………………Yuzhuo Wang, Yiming Zhang, Xiaolian Dong, Xuecai Wang, Jianfu Zhu, Na Wang, Feng Jiang, Yue Chen, Qingwu Jiang, Chaowei Fu(483)

The evaluation of genomic homozygosity for Xinjiang inbred population by SNP panels……………………………………………………………………Rui Shi, Yi Zhang, Yachun Wang, Tao Huang, Guochang Lu, Tao Yue, Zhenxi Lu, Xixia Huang, Xinpu Wei, Shutang Feng, Jun Chen, Wulan Kagedeer, Ruxianguli Abulizi, Nuerhumaer Muhetaer(493)

Analysis of rice root bacterial microbiota of Nipponbare and IR24……………………………………………………………………Yali Hu, Rui Dai, Yongxin Liu, Jingying Zhang, Bin Hu, Chengcai Chu, Huaibo Yuan, Yang Bai(506)

No. 6

Frontier Focus

Prime editing creates a novel dimension of plant precise genome editing……………………………………………………………………Ruiying Qin, Pengcheng Wei(519)

Review

Research progress of proteins related to sperm tail development……………………………………………………………………Yanan Zhong, Changmin Niu, Mengmeng Xia, Ying Zheng(524)

The mechanism underlying histone deacetylases regulating cardiac hypertrophy……………………………………………………………………Lian Ren, Xiushan Wu, Yongqing Li(536)

The regulation of ubiquitination in milk fat synthesis in bovine……………………………………………………………………Lili Liu, Aiwei Guo, Qingqing Li, Peifu Wu, Yajin Yang, Fenfen Chen, Suhua Li, Panjiang Guo, Qin Zhang(548)

Genome editing in plants directed by CRISPR/Cas ribonucleoprotein complexes……………………………………………………………………Xia Li, Wan Shi, Lizhao Geng, Jianping Xu(556)

Research Article

A genetic sub-structure study of the Tibetan population in Southwest China……………………………………………………………………Xiaojuan Wang, Enfang Qian, Yue Li, Zhengyang Song, Hui Zhao, Hexin Xie, Caixia Li, Jiang Huang, Li Jiang(565)

The development of a general drug resistance score model based on MIC50related genepairs in colorectal cancer cell lines……………………………………………………………………Huxing Chen, Lei Xu, Jing Li, Zheng Guo, Lu Ao(577)

Toxicity reduction of human islet amyloid polypeptide by Trim-Away technique in insulinoma cells……………………………………………………………………Jiawei Gong, Delin Kong, Lin Yang, Yuzhe Nie, Yang Liang, Chun-Bo Teng(586)

Technique and Method

A method of screening highly common neoantigens with immunogenicity in colorectal cancer based on public somatic mutation library……………………………………………………………………Lili Qin, Yijian Li, Zhaoduan Liang, Lei Chen, Wenhui Li, Chao Chen, Yaling Huang, Le Zhang, Songming Liu, Si Qiu, Yuping Ge, Wenting Peng, Xinxin Lin, Xiuqing Zhang, Xuan Dong, Bo Li(599)

No. 7

Invited Review

-regulatory mechanisms and biological effects of translation elongation……………………………………………………………………Taolan Zhao, Shuo Zhang, Wenfeng Qian(613)

Review

The role of DNA hydroxymethylation in the regulation of atherosclerosis……………………………………………………………………Yingchu Hu, Haochang Hu, Shaoyi Lin, Xiaomin Chen(632)

Recent developments in enhancing the efficiency of CRISPR/Cas9-mediated knock-in in animals……………………………………………………………………Guoling Li, Shanxin Yang, Zhenfang Wu, Xianwei Zhang(641)

Application of CRISPR/Cas9 mediated gene editing in trees……………………………………………………………………Yingnan Chen, Jing Lu(657)

Research Article

SLFN14 inhibits LINE-1 transposition activity……………………………………………………………………Yang Mao, Jiwei Ding, Minshu Chen, Shan Cen, Xiaoyu Li(669)

Human facial shape related SNP analysis in Han Chinese populations……………………………………………………………………Ming Liu, Yi Li, Yafang Yang, Yuwen Yan, Fan Liu, Caixia Li, Faming Zeng, Wenting Zhao(680)

Comprehensive re-annotation of protein-coding genes for prokaryotic genomes by Z-curve and similarity-based methods……………………………………………………………………Shuo Liu, Zhi Zeng, Fancai Zeng, Mengze Du(691)

Technique and Method

A method for reliable detection of genomic point mutations based on single-cell target-sequencing……………………………………………………………………Linan Zhao, Na Wang, Guoliang Yang, Xianbin Su, Zeguang Han(703)

No. 8

Review

G protein-coupled receptor-associated sorting proteins: function and relevant disorders……………………………………………………………………Min Zhang, Lihong Liang, Yajie Lu, Xin Cao(713)

Zebrafish blood disease models and applications……………………………………………………………………Jiani Guo, Fan Liu, Lu Wang(725)

Progress on the mechanism of hormones regulating plant flower formation……………………………………………………………………Liping Zou, Cheng Pan, Mengxin Wang, Lin Cui, Baoyu Han(739)

Progress on phage genomics ofspp.……………………………………………………………………Zhiwei Xu, Yunlin Wei, Xiuling Ji(752)

Research Article

RFX5 regulates gene expression of thecluster……………………………………………………………………Na Wang, Zhilian Jia, Qiang Wu(760)

Prognostic and predictive value of a DNA methylation-driven transcriptional signature in hepatocellular carcinoma……………………………………………………………………Hongbo Luo, Pengbo Cao, Gangqiao Zhou(775)

Cloning of the soybean E2 ubiquitin-conjugating enzymeand its expression in……………………………………………………………………Zhuozhuo Mao, Yu Gong, Guixia Shi, Yali Li, Deyue Yu, Fang Huang(788)

Resource and Platform

CNGBdb: China National GeneBank DataBase……………………………………………………………………Fengzhen Chen, Lijin You, Fan Yang, Lina Wang, Xueqin Guo, Fei Gao, Cong Hua, Cong Tan, Lin Fang, Riqiang Shan, Wenjun Zeng, Bo Wang, Ren Wang, Xun Xu, Xiaofeng Wei(799)

Genetics Teaching

Application of formative evaluation and teaching feedback in PBL teaching of Medical Genetics……………………………………………………………………Tao Wang, Liang Liang, Minhua Zheng(810)

No. 9

Review

The identification of enhancers and its application in cancer studies……………………………………………………………………Qian Liu, Chunyan Li(817)

Advances in genome-wide association study of chronic obstructive pulmonary disease……………………………………………………………………Guoqing Qian(832)

Lamprey: an important animal model of evolution and disease research……………………………………………………………………Yigao Zhu, Jun Li, Yue Pang, Qingwei Li(847)

Progress on the biosynthesis and signal transduction of phytohormone salicylic acid……………………………………………………………………Xiaoyong Gu, Yang Liu, Lijing Liu(858)

New molecular diagnostic technologies for clinical detection of SARS-CoV-2……………………………………………………………………Chunmei Xie, Haiping Wu, Xueping Ma, Guohua Zhou(870)

Research Article

Telomere length and type 2 diabetes: Mendelian randomization study and polygenic risk score analysis……………………………………………………………………Lan Cao, Zhiqiang Li, Yongyong Shi, Yun Liu(882)

The osteoporosis susceptible SNP rs4325274 remotely regulates the SOX6 gene through enhancers……………………………………………………………………Xiaomei Tuo, Dongli Zhu, Xiao feng Chen, Yu Rong, Yan Guo, Tie-Lin Yang(889)

Transcriptome heterogeneity of porcine ear fibroblast and its potential influence on embryo development in nuclear transplantation……………………………………………………………………Jun Zhou, Chengcheng Zhao, Xiao Wu, Junsong Shi, Rong Zhou, Zhenfang Wu, Zicong Li(898)

Genetics Teaching

The applications of research progress of common wheat in teaching genetics……………………………………………………………………Na Zhao, Bao Qi, Qianli Dong, Xiaoli Wang(916)

No. 10

Review

Progress in elucidating the origin of eukaryotes……………………………………………………………………Zhiwei Gao, Long Wang(929)

Advances in gene therapy for β-thalassemia and hemophilia based on the CRISPR/Cas9 technology……………………………………………………………………Liwen Bao, Yiye Zhou, Fanyi Zeng(949)

Progress on the molecular mechanisms of PCSK9-mediated degradation of low density lipoprotein receptor……………………………………………………………………Yuxian Wu, Yan Wang(965)

Progress on signal pathways related to bone metabolism in animals……………………………………………………………………Jingying Zhao, Xiaohua Duan, Qiuting Wang, Ying Huang, Junjing Jia, Tengfei Dou(979)

Progress on abnormal development of cloned pigs generated by somatic cell transfer nuclear……………………………………………………………………Zheng Ao, Xiang Chen, Zhenfang Wu, Zicong Li(993)

Research Article

Related genes and characteristic analysis of trophoblast cells during early embryo developmental cessation……………………………………………………………………Yue Zhang, Ying Feng, Fang Ma(1004)

Construction of a striatum-specificgene knockout mice model by CRISPR/Cas9 AAV system……………………………………………………………………Minting Lin, Lulu Lai, Miao Zhao, Biwei Lin, Xiangping Yao(1017)

Technique and Method

A multiplex PCR method based on nuclear and cytoplasmic inheritance to identify the horse and donkey-derived components ofand the hide……………………………………………………………………Yang Shen, Wenjun Wang, Ming Fu, Guoqiang Xu, Xiang Zhou, Bang Liu(1028)

No. 11

Review

Induced pluripotent stem cell technology and its application in disease research……………………………………………………………………Chenyi Cai, Feilong Meng, Lin Rao, Yunyue Liu, Xiaoli Zhao(1042)

The role of miRNA in kidney development……………………………………………………………………Xiaoqi Zhao, Ying Ao, Haiyun Chen, Hui Wang(1062)

Research progress of stem cells in agricultural animals……………………………………………………………………Bingyuan Wang, Yulian Mu, Kui Li, Zhiguo Liu(1073)

Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle……………………………………………………………………Huiyou Chen, Jianmin Zhang, Baisen Li, Yonglin Deng, Gongwei Zhang(1081)

Progress on genome sequencing of Dipteran insects……………………………………………………………………Wei Peng, Mengjie Feng, Hao Chen, Baoyu Han(1093)

Research Article

Thepromoter could function as an active enhancer to regulate the expression ofin the apoptosis response ……………………………………………………………………Zhongyong Qin, Xiao Shi, Pingping Cao, Ying Chu, Wei Guan, Nan Yang, He Cheng, Yujie Sun(1110)

Functional analysis ofgene intestis……………………………………………………………………Wanyin Chen, Yidan Yan, Xiaojin Luan, Min Wang, Jie Fang(1122)

Genetics Teaching

Cultivation of undergraduates’ self-regulated learning ability in Medical Genetics based on PAD class……………………………………………………………………Yuling Yang, Lan Luo, Yuan Qian, Fang Yang(1133)

No. 12

Review

Resolving nucleosomal positioning and occupancy with MNase-seq……………………………………………………………………Weihang Deng, Xinhui Li(1143)

The effects of m6A modification in central nervous system function and disease……………………………………………………………………Jiabin Shi, Dayong Wang, Qing Xia, Xu Gao(1156)

Advances in precise regulation of CRISPR/Cas9 gene editing technology……………………………………………………………………Junxia Cao, Youliang Wang, Zhengxu Wang(1168)

circRNA on animal skeletal muscle development regulation……………………………………………………………………Ting Zheng, Mailin Gan, Linyuan Shen, Lili Niu, Zongyi Guo, Jinyong Wang, Shunhua Zhang, Li Zhu(1178)

Research Article

genotoxicity study of silver nanoparticles and titanium dioxide nanoparticles……………………………………………………………………Haimei Zhu, Pengcheng Huang, Tiantian Zhao, Changhui Zhou, Ruowan Li, Chunrong Yu, Zhiyong Chen, Linfeng Gu, Yan Chang(1192)

RNA-binding protein Roquin negatively regulates STING-dependent innate immune response in……………………………………………………………………Beibei Du, Lei Liu, Yangyang Zhu(1201)

Genetics Teaching

How to teach genetic drift……………………………………………………………………Chunming Wang, Changjun Lin, Huyuan Feng(1211)

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