复方血栓通胶囊联合胞二磷胆碱治疗青光眼视神经萎缩的临床效果

余江平 张学敏

[摘要] 目的 探讨青光眼视神经萎缩患者应用复方血栓通胶囊与胞二磷胆碱联合治疗的临床效果。方法 方便选择该院2015年3月—2018年3月收治的青光眼视神经萎缩患者作为研究对象，共计纳入90例，入组对象签署知情同意书愿意配合研究，按照随机数表法分为单用组与联合组，每组45例。其中单用组患者予以胞二磷胆碱治疗，联合组则采取复方血栓通胶囊与胞二磷胆碱联合治疗。评价两组患者视力效果、视野效果，测定治療前与治疗后视力、总灰度值、视野光敏度、视野缺损度情况。结果 联合组患者视力总有效率、视野总有效率依次为93.33%、88.89%，单用组则分别为80.00%、75.56%，联合组前述总有效率均高于单用组（P<0.05）；两组患者治疗前视力、总灰度值、视野光敏度、视野缺损度比较差异无统计学意义（P>0.05），治疗后联合组前述指标均优于单用组（P<0.05）。结论 青光眼视神经萎缩患者采取复方血栓通胶囊与胞二磷胆碱联合治疗可以更好地改善视力效果与视野效果，同时在改善视力、总灰度值、视野光敏度、视野缺损度等方面也有不错的优势，值得推广应用。

[关键词] 青光眼；视神经萎缩；复方血栓通胶囊；胞二磷胆碱；效果

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2019）03（b）-0146-03

[Abstract] Objective To investigate the clinical effect of combined treatment of compound Xueshuantong capsule and citicoline in patients with glaucoma optic atrophy. Methods Patients with glaucomatous optic atrophy admitted to our hospital from March 2015 to March 2018 were convenient selected and enrolled in this study. A total of 90 patients were enrolled. The enrolled subjects signed an informed consent form and were willing to cooperate with the study. They were divided into single use group and the combined group， n=45 cases per group according to the random number table method. The patients in the single-use group were treated with citicoline， and the combined group was treated with compound Xueshuantong capsule and citicoline. The visual acuity and visual field effect of the two groups were evaluated. The visual acuity， total gray value， visual field sensitivity and visual field defect degree before and after treatment were measured. Results The total effective rate and total visual acuity of the combined group were 93.33% and 88.89%， respectively， and the single use group was 80.00% and 75.56% respectively. The total effective rate of the combined group was higher than that of the single use group （P<0.05）. There was no significant difference in pre-treatment visual acuity， total gray value， visual field sensitivity， and visual field defect between the two groups （P>0.05）. The above-mentioned indicators in the combined group were better than the single-use group （P<0.05）. Conclusion The combination of compound Xueshuantong Capsule and citicoline in glaucoma optic atrophy can improve the visual effect and visual field effect， and also improve the visual acuity， total gray value， visual field sensitivity， and visual field defect， it is worth promoting.

[Key words] Glaucoma； Optic atrophy； Compound thrombosis capsule； Citicoline； Effect

青光眼属于常见眼科疾病，指的是眼压升高或者低灌注压等所致视神经损害性疾病，而且多伴有视神经萎缩，常表现出慢性视力与视野损害等症状。过去对青光眼视神经萎缩治疗主要采取营养神经性药物、活血通脉药物等治疗，但这些治疗方案预后并不理想[1]。为了寻找更为有效、安全的治疗方案，近几年通过不断研究与探索，一些学者指出复方血栓通胶囊与胞二磷胆碱联合治疗青光眼视神经萎缩可取得不错的效果[2-3]，其中胞二磷胆碱属于核苷衍生物，不仅可参与神经组织磷脂与蛋白质合成，促进这种合成，而且还可调节血管张力，使得神经组织代谢得到改善[4-5]。为了进一步探讨青光眼视神经萎缩患者应用复方血栓通胶囊与胞二磷胆碱联合治疗的临床效果，分析该院2015年3月—2018年3月间收治的90例青光眼视神经萎缩患者的临床资料，报道如下。