糖尿病性牙周炎患者应用牙周基础治疗与替硝唑胶囊治疗的疗效分析

张永辉+汪欣虹+姜慧腾

【摘要】 目的：分析糖尿病性牙周炎患者单用牙周基础治疗与联合替硝唑胶囊治疗的临床效果。方法：选取2012年1月-2016年12月本院收治的确诊为糖尿病性牙周炎的患者82例，按照随机数字表法将其分为对照组和观察组，各41例。对照组予以牙周基础治疗，观察组在对照组基础上联合予以替硝唑胶囊治疗。对比两组治疗前后的菌斑指数、龈沟出血指数、附着丧失、松动度检出差异，并就治疗期间两组的不良反应发生情况进行统计观察。结果：治疗前，两组菌斑指数、龈沟出血指数、附着丧失、松动度比较，差异均无统计学意义（P>0.05）；治疗后，观察组菌斑指数、龈沟出血指数、附着丧失、松动度分别为（0.8±0.1）、（0.7±0.1）、（1.8±0.3）mm、（1.0±0.2）mm，均显著低于对照组（P<0.05）；两组不良反应总发生率比较，差异无统计学意义（P>0.05）。结论：糖尿病性牙周炎患者在牙周基础治疗同时联合替硝唑胶囊治疗可进一步巩固疗效，改善牙周炎相关症状，且无明显不良反应，联合用药安全可靠，值得在临床实践中进一步推广。

【关键词】 糖尿病； 牙周炎； 替硝唑胶囊； 疗效

【Abstract】 Objective：To analyze the clinical effect of single periodontal basic therapy and combined with Tinidazole Capsules in treatment of diabetic periodontitis.Method：82 cases of diabetic periodontitis from January 2012 to December 2016 in our hospital were selected，according to random number table，they were divided into control group and observation group，41 cases in each group.The control group was treated with periodontal basic therapy，and observation group was treated with Tinidazole Capsules on basis of control group.The plaque index，sulcus bleeding index，attachment loss and looseness were compared between two groups before and after treatment，and the incidence of adverse reactions of two groups during treatment were statistically observed.Result：Before treatment，the plaque index，sulcus bleeding index，attachment loss and looseness of two groups were compared，the difference were not statistically significant（P>0.05）；after treatment，the plaque index，sulcus bleeding index，attachment loss and looseness of observation group were（0.8±0.1），（0.7±0.1），（1.8±0.3） mm，（1.0±0.2） mm respectively，which were significantly lower than those of control group（P<0.05）；the total incidence of adverse reactions of two groups were compared，the difference was not statistically significant（P>0.05）.Conclusion：Periodontal basic therapy and combined with Tinidazole Capsules in treatment of diabetic periodontitis can further consolidate the curative effect，improve periodontitis related symptoms，and no obvious adverse reactions，combined medication is safe and reliable，and is worthy of further promotion in clinical practice.

【Key words】 Diabetes； Periodontitis； Tinidazole Capsules； Efficacy

First-authors address：The Third Peoples Hospital of Jingdezhen，Jingdezhen 333000，China

doi：10.3969/j.issn.1674-4985.2017.33.013

在社會发展水平不断提升与加快的背景下，大众饮食结构进一步调整，生活方式也发生了明显的转变[1]。在大量因素的作用下，糖尿病临床发病率正逐年上升。既往有关报道中指出，糖尿病与牙周炎具有非常密切的双星关系，发病危险性高度一致，即糖尿病是导致牙周炎发病率上升的独立危险性因素[2-3]。既往研究证实，糖尿病会造成牙周炎病情加重，发病率上升，而糖尿病同时也是导致牙周炎形成发展的最主要原因之一[4-6]。对于糖尿病性牙周炎患者而言，若临床诊治不及时，可能导致患者出现一系列并发症，如糖尿病肾病、糖尿病足、心血管疾病等[7]。通过对糖尿病性牙周炎患者牙周炎症的科学治疗与干预，能够帮助患者控制血糖水平，临床价值备受医务人员关注与重视。为分析糖尿病性牙周炎患者单用牙周基础治疗与联合替硝唑胶囊治疗的临床疗效，本研究选取2012年endprint