A comparative study of pancreatic endocrine function and related metabolism after long－term survival between the patients with combined kidneypancreas transplantation vs those with combined en bloc＇liver－ pancreas transplantation

Zhu Xiaofeng(朱晓峰，Dept Organ Transplant，1st Affil Hosp，Sun Yet－sen Univ，Guangzhou 510080)…∥Chin J Organ Transplant.－2011，32(5).－264 ～267

A comparative study of pancreatic endocrine function and related metabolism after long－term survival between the patients with combined kidneypancreas transplantation vs those with combined en bloc＇liver－ pancreas transplantation

Zhu Xiaofeng(朱晓峰，Dept Organ Transplant，1st Affil Hosp，Sun Yet－sen Univ，Guangzhou 510080)…∥Chin J Organ Transplant.－2011，32(5).－264 ～267

ObjectiveTo compare the effects of combined en bloc liver－pancreas transplantation(LPT)with portal vein drainage and simultaneous combined kidney－pancreas transplantation(KPT)with systemic venous drainage on the pancreatic endocrine function and related metabolism.MethodsFour LPT patients and 6 KPT ones with normal hepato－renal function，good quality of life and periodic follow－up received measurement of serum insulin，insulin provocation test，fasting glucose，oral glucose tolerance test，C － peptide，glycated hemoglobin，triglyceride and total cholesterol;and their laboratory test parameters were compared and analyzed.Results

In KPT group，2－h insulin level，C －peptide level and total cholesterol level were significantly higher at 6th month，3rd and 6th month postoperation all P ＜0.05.But there was no significant difference in other parameters between the two groups at 6th month after operation.ConclusionEither KPT or LPT can achieve excellent endocrine function，carbohydrate and lipid metabolism;and the results show that portal venous drainage does not offer major metabolic advantages within 6 months after operation，11 refs，10 figs.

(Authors)