REVIEWS

1. Molecular mechanosensors in osteocytes
2. Exosomes:roles and therapeutic potential in osteoarthritis

ORIGINAL ARTICLES

1. A variant in IL6ST with a selective IL-11 signaling defect in human and mouse
2. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 in flammasome positive feedback loop
3. Ionomycin ameliorateshypophosphatasia via rescuing alkaline phosphatase de ficiency-mediated L-type Ca2+channel internalization in mesenchymal stem cells
4. uPAR antibody(huATN-658)and Zometa reduce breast cancer growth and skeletal lesions
5. Dystrophic calci fication and heterotopic ossi fication in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis(DISH)
6. ZBP1(DAI/DLM-1)promotesosteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling
7. Osteoclasts are not a source of SLIT3
8. Skeletal loading regulatesbreast cancer-associated osteolysisin a loading intensity-dependent fashion